The Proteomics and Metabolomics Shared Resource (PMSR) supported in part by the Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) provides advanced mass spectrometry services, technologies and scientific consultation.
Studies focus on discovery, identification, characterization, and quantification of biomolecules, including proteins, lipids and metabolites by analytical and biochemical methods applied to all types of biological materials (cells, tissue, biological fluids), including clinical specimens.
Tesfay L, Paul BT, Konstorum A, Deng Z, Cox AO, Lee J, Furdui CM, Hegde P, Torti FM, Torti SV. Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death. Cancer Res. 2019 Oct 15;79(20):5355-5366. PMID: 31270077 PMCID: PMC6801059.
Atkins HM, Bharadwaj MS, O'Brien Cox A, Furdui CM, Appt SE, Caudell DL. Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol. 2019 Aug 24;17(1):70. PMID: 31445519; PMCID: PMC6708555.
Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS. Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading. Radiat Res. 2019 Jun;191(6):497-506. PMID: 30925135 PMCID: PMC6599637
Chen X, Lee J, Wu H, Tsang AW, Furdui CM. Mass Spectrometry in Advancement of Redox Precision Medicine. Adv Exp Med Biol. 2019;1140:327-358. PMID: 31347057
Peak TC, Praharaj PP, Panigrahi GK, Doyle M, Su Y, Schlaepfer IR, Singh R,Vander Griend DJ, Alickson J, Hemal A, Atala A, Deep G. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells. Biochem Biophys Res Commun. 2018 May 23;499(4):1004-1010. Epub 2018 Apr 9. PubMed PMID: 29627574; PubMed Central PMCID: PMC5929996.
Yang M, Wu H, Chu J, Gabriel LA, Kim Y, Anderson KS, Furdui CM, Bierbach U. Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent. Chem Commun (Camb). 2018 Jul 11;54(54):7479-7482. Epub 2018 Jun 19. PubMed PMID: 29915817.
Vitolins MZ, Case LD, Rapp SR, Lively MO, Shaw EG, Naughton MJ, Giguere J, Lesser GJ. Self-reported adherence and biomarker levels of CoQ10 and alpha-tocopherol. Patient Prefer Adherence. 2018 Apr 24;12:637-646. PMID: 29731611; PMCID: PMC5923253.
Keyes JD, Parsonage D, Yammani RD, Rogers LC, Kesty C, Furdui CM, Nelson KJ, Poole LB. Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med. 2017 Nov;112:534-543. PubMed PMID: 28843779; PubMed Central PMCID: PMC5623068.
Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U. Human Serum Albumin-Delivered [Au(PEt3)]+ Is a Potent Inhibitor of T Cell Proliferation. ACS Med Chem Lett. 2017 Apr 25;8(5):572-576. PMID: 28523113; PMCID: PMC5430400.
Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis T. The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch. Antioxid Redox Signal. 2017 Dec 1;27(16):1317-1331. doi: 10.1089/ars.2016.6888. Apr 18. PMID: 28398823; PMCID: PMC5655415.
Datta M, Shaw EG, Lesser GJ, Case LD, Vitolins MZ, Schneider C, Frizzell B, Sullivan C, Lively M, Franzmann E, Hu JJ. A Randomized Double-Blind Placebo-Controlled Trial of Fruit and Vegetable Concentrates on Intermediate Biomarkers in Head and Neck Cancer. Integr Cancer Ther. 2018 Mar;17(1):115-123. Epub 2017 Jan 19. PMID: 28102098; PMCID: PMC5501769.
Atkins HM, Bharadwaj MS, O'Brien Cox A, Furdui CM, Appt SE, Caudell DL. Endometrium and endometriosis tissue mitochondrial energy metabolism in a nonhuman primate model. Reprod Biol Endocrinol. 2019 Aug 24;17(1):70. PMID: 31445519; PMCID: PMC6708555.
Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS. Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading. Radiat Res. 2019 Jun;191(6):497-506. PMID: 30925135 PMCID: PMC6599637
Chen X, Lee J, Wu H, Tsang AW, Furdui CM. Mass Spectrometry in Advancement of Redox Precision Medicine. Adv Exp Med Biol. 2019;1140:327-358. PMID: 31347057
Peak TC, Praharaj PP, Panigrahi GK, Doyle M, Su Y, Schlaepfer IR, Singh R,Vander Griend DJ, Alickson J, Hemal A, Atala A, Deep G. Exosomes secreted by placental stem cells selectively inhibit growth of aggressive prostate cancer cells. Biochem Biophys Res Commun. 2018 May 23;499(4):1004-1010. Epub 2018 Apr 9. PubMed PMID: 29627574; PubMed Central PMCID: PMC5929996.
Yang M, Wu H, Chu J, Gabriel LA, Kim Y, Anderson KS, Furdui CM, Bierbach U. Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent. Chem Commun (Camb). 2018 Jul 11;54(54):7479-7482. Epub 2018 Jun 19. PubMed PMID: 29915817.
Vitolins MZ, Case LD, Rapp SR, Lively MO, Shaw EG, Naughton MJ, Giguere J, Lesser GJ. Self-reported adherence and biomarker levels of CoQ10 and alpha-tocopherol. Patient Prefer Adherence. 2018 Apr 24;12:637-646. PMID: 29731611; PMCID: PMC5923253.
Keyes JD, Parsonage D, Yammani RD, Rogers LC, Kesty C, Furdui CM, Nelson KJ, Poole LB. Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals. Free Radic Biol Med. 2017 Nov;112:534-543. PubMed PMID: 28843779; PubMed Central PMCID: PMC5623068.
Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U. Human Serum Albumin-Delivered [Au(PEt3)]+ Is a Potent Inhibitor of T Cell Proliferation. ACS Med Chem Lett. 2017 Apr 25;8(5):572-576. PMID: 28523113; PMCID: PMC5430400.
Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis T. The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch. Antioxid Redox Signal. 2017 Dec 1;27(16):1317-1331. doi: 10.1089/ars.2016.6888. Apr 18. PMID: 28398823; PMCID: PMC5655415.
Datta M, Shaw EG, Lesser GJ, Case LD, Vitolins MZ, Schneider C, Frizzell B, Sullivan C, Lively M, Franzmann E, Hu JJ. A Randomized Double-Blind Placebo-Controlled Trial of Fruit and Vegetable Concentrates on Intermediate Biomarkers in Head and Neck Cancer. Integr Cancer Ther. 2018 Mar;17(1):115-123. Epub 2017 Jan 19. PMID: 28102098; PMCID: PMC5501769.
