The Proteomics and Metabolomics Shared Resource (PMSR) supported in part by the Atrium Health Wake Forest Baptist Comprehensive Cancer Center (AHWFBCCC) provides advanced mass spectrometry services, complementary assays (e.g., mitochondrial energy metabolism) and scientific consultation.
PMSR services focus on discovery, identification, characterization and quantification of biomolecules, including proteins, lipids and metabolites and other small molecules (e.g., drugs, dietary supplements) applied to all types of biological materials (cells, tissue, biological fluids), including clinical specimens.
In addition to the fee-for-service analyses, the PMSR offers options to accommodate various needs such as training and project-based collaborations.
Focus Areas
The PMSR focuses on the implementation of state-of-the-art MS techniques in translational and clinical research.
- Integration of molecular and multi-omics approaches into functional diagnostic platforms.
- Discovery of novel clinical targets (single proteins or interactomes).
- Validation of clinical biomarkers for early non-invasive diagnosis and disease monitoring.
- Identification of biomarkers of response to drugs or other therapies.
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8. Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, et al. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine 2021;63:103192
9. Holmila R, Wu H, Lee J, Tsang AW, Singh R, Furdui CM. Integrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles. Mol Cell Proteomics 2021;20:100073
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12. Poole LB, Parsonage D, Sergeant S, Miller LR, Lee J, Furdui CM, et al. Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids. Biotechnol Biofuels 2020;13:83
13. Bayne RS, Puckett S, Rodrigues LU, Cramer SD, Lee J, Furdui CM, et al. MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells. Mol Ther Oncolytics 2020;17:496-507
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