The Proteomics and Metabolomics Shared Resource (PMSR) supported in part by the Atrium Health Wake Forest Baptist Comprehensive Cancer Center (AHWFBCCC) provides advanced mass spectrometry services, complementary assays (e.g., mitochondrial energy metabolism) and scientific consultation.
PMSR services focus on discovery, identification, characterization and quantification of biomolecules, including proteins, lipids and metabolites and other small molecules (e.g., drugs, dietary supplements) applied to all types of biological materials (cells, tissue, biological fluids), including clinical specimens.
In addition to the fee-for-service analyses, the PMSR offers options to accommodate various needs such as training and project-based collaborations.
Focus Areas
The PMSR focuses on the implementation of state-of-the-art MS techniques in translational and clinical research.
- Integration of molecular and multi-omics approaches into functional diagnostic platforms.
- Discovery of novel clinical targets (single proteins or interactomes).
- Validation of clinical biomarkers for early non-invasive diagnosis and disease monitoring.
- Identification of biomarkers of response to drugs or other therapies.
1. Forshaw TE, Shukla K, Wu HZ, Sergeant S, Lee J, Tsang AW, Morris PE, Gibbs KW, Files DC, Furdui CM. A proteomics and redox proteomics approach to understanding ARDS heterogeneity. Sci Rep-Uk. 2026;16(1). doi: ARTN 6034 10.1038/s41598-026-35606-2. PubMed PMID: WOS:001691108800012.
2. Petronek MS, Stolwijk JM, Zaher A, Owusu SB, Cooke J, Ekanayake AB, Tivanski AV, Lee J, Furdui CM. Gallium disrupts endoplasmic reticulum iron metabolism to induce lipid metabolic reprogramming in glioblastoma cells. iScience. 2025;28(5):112404. Epub 20250412. doi: 10.1016/j.isci.2025.112404. PubMed PMID: 40469110; PMCID: PMC12136846.
3. Mosquea YRF, Buchele MLC, Parsonage D, Lee J, Mundra S, Campbell SL, Poole LB, Furdui CM. Impact of KRASG12C oxidation state on non-small-cell lung cancer response to targeted therapeutics. Cancer Research. 2025;85(8). doi: 10.1158/1538-7445.Am2025-6997. PubMed PMID: WOS:001500371006116.
4. Lin Z, Luo X, Wickman JR, Reddy D, DaCunza JT, Pande R, Tian Y, Kasimoglu EE, Triana V, Lee J, Furdui CM, Pink D, Sacan A, Ajit SK. Inflammatory pain resolution by mouse serum-derived small extracellular vesicles. Brain Behav Immun. 2025;123:422-41. Epub 20240929. doi: 10.1016/j.bbi.2024.09.032. PubMed PMID: 39349284; PMCID: PMC12004123.
5. Lee J, Chen X, Fanning KM, Si C, Davis AT, Wasserman DH, Bracy D, Furdui CM, Kavanagh K. Persistent Postirradiation Skeletal Muscle Protein and Insulin Sensitivity Changes in Nonhuman Primates. Radiat Res. 2025. Epub 20250307. doi: 10.1667/RADE-23-00223.1. PubMed PMID: 40053841.
6. Jester HM, Nicol N, Yang Q, Zhang YK, Suhocki A, Zhou XY, Underwood E, Pourhadi H, Cheng DM, Lee J, Sun PQ, Furdui CM, Proud CG, Rosenblum K, Ma T. Overactive Neuronal eEF2K/eEF2 signaling is associated with cognitive impairment and apathy-like behavior. Molecular Psychiatry. 2025. doi: 10.1038/s41380-025-03408-z. PubMed PMID: WOS:001637706900001.
7. Han Z, Yan Z, Ma Z, Wang Y, Beus M, Lu J, Weidenhammer LB, Lakhani K, Lee J, Civils JD, Furdui CM, Liu L, Wu J, Kang Y, Bieberich E, Boise LH, Nikiforov MA. Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma. Leukemia. 2025;39(3):720-33. Epub 20250130. doi: 10.1038/s41375-025-02522-9. PubMed PMID: 39885295; PMCID: PMC12175649.
8. Fearing BV, Romereim SM, Danelson K, Smykowski M, Barankevich M, Serbin R, Chintalapudi N, Davis J, Appt S, Burkart H, Seymour RB, Hsu JR. Development of a small animal bone-anchored limb replacement model for infection interventions. OTA Int. 2025;8(1 Suppl):e366. Epub 20250307. doi: 10.1097/OI9.0000000000000366. PubMed PMID: 40071169; PMCID: PMC11892714.
9. Akbarzadeh T, Ma L, Lee J, Moore J, Chou W, Shabani S, Furdui CM, Parvin B, Barcellos-Hoff MH. Plasma proteomic analysis reveals complement system changes in irradiated female BALB/c mice during mammary carcinogenesis. Cancer Res Commun. 2025. Epub 20250804. doi: 10.1158/2767-9764.CRC-25-0183. PubMed PMID: 40757647.
10. Mishra S, Kumar A, He YE, Su YX, Singh S, Santos MF, Singh R, Lee JY, Furdui CM, Shively CA, Kritchevsky SB, Register TC, Deep G. Circulating small extracellular vesicles as blood-based biomarkers of muscle health in aging nonhuman primates. Geroscience. 2024. doi: 10.1007/s11357-024-01439-y. PubMed PMID: WOS:001375886200001.
11. Makkaoui N, Prasad V, Bagchi P, Carmona T, Li K, Latham O, Zhang Y, Lee J, Furdui C, Maxwell J. Cell-based therapies reverse the heart failure-altered right ventricular proteome. Res Sq. 2024. Epub 20240906. doi: 10.21203/rs.3.rs-4752035/v1. PubMed PMID: 39281857; PMCID: PMC11398576.
12. Lee J, Wang ZM, Messi ML, Milligan C, Furdui CM, Delbono O. Sex differences in single neuron function and proteomics profiles examined by patch-clamp and mass spectrometry in the locus coeruleus of the adult mouse. Acta Physiol (Oxf). 2024;240(4):e14123. Epub 20240308. doi: 10.1111/apha.14123. PubMed PMID: 38459766; PMCID: PMC11021178.
13. Kumar A, Cleary JA, Su Y, Singh S, Howard M, Hayden KM, Lee J, Furdui CM, Espeland MA, Ding J, Deep G. Multi-omics analysis of neuron-derived small extracellular vesicles to identify novel peripheral biomarker of cognitive impairment in individuals with type 2 diabetes. Alzheimer's & Dementia. 2024;20(S2):e091878. doi: https://doi.org/10.1002/alz.091878.
14. Kim E, Kim H, Bowman J, Lee J, Furdui CM, Ahn B. Unacylated Ghrelin Protects Against Muscle Wasting, Mitochondrial Dysfunction, and Neuromuscular Junction Disruption in Tumor Bearing Mice. Physiology. 2024;39(S1):725. doi: 10.1152/physiol.2024.39.S1.725. PubMed PMID: 37962895.
15. Gonzalez-Armenta JL, Bergstrom J, Lee J, Furdui CM, Nicklas BJ, Molina AJA. Serum factors mediate changes in mitochondrial bioenergetics associated with diet and exercise interventions. Geroscience. 2024;46(1):349-65. Epub 20230627. doi: 10.1007/s11357-023-00855-w. PubMed PMID: 37368157; PMCID: PMC10828137.
