The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies. Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies – all with the goal to cure, rather than merely treat, disease.

The Wake Forest Institute for Regenerative Medicine is working to grow tissues and organs and develop healing cell therapies for more than 30 different areas of the body, from kidney and trachea to cartilage and lung. We’re an international leader in translating scientific discovery into clinical therapies and our scientists have been first in the world to implant lab-grown tissues and organs into patients.

Today, we continue to develop replacement tissues and organs, and are also working to speed up the availability of these treatments to patients. For example, we have a support infrastructure, including a clinical manufacturing center, designed to accelerate the translation of discoveries. In addition, we are:

  • Leading a multi-center, results-focused program for the military that requires that discoveries be tested and compared so that the most promising therapies can be brought to clinical trials.
  • Leading a five-center effort to print mini-organs for drug testing. The lessons learned can be applied to replacement organs for patients.
  • Looking to the future by working to apply the principles of modern manufacturing to regenerative medicine.

The Next Evolution of Medical Treatments

Regenerative medicine has been called the "next evolution of medical treatments" by the U.S. Department of Health and Human Services. With its potential to heal, this new field of science is expected to revolutionize healthcare. It is our mission at WFIRM to improve patients' lives by developing regenerative medicine therapies and support technologies.

"We have many challenges to meet, but are optimistic about the ability of the field to have a significant impact on human health. We believe regenerative medicine promises to be one of the most pervasive influences on public health in the modern era."  Read the full Director's Welcome
- Anthony Atala, MD, Chair and Institute Director

Regenerative Medicine 101

Regenerative medicine may sound like science fiction, but it is based on a simple premise.