The Cancer Genomics Shared Resource (CGSR) of the Wake Forest Baptist Comprehensive Cancer Center is a National Cancer Institute (NCI)-supported laboratory that provides comprehensive genomic, transcriptomic and epigenomic profiling analyses for research and diagnostic purposes.

The CGSR provides users with a coordinated approach to conduct research, working closely with other WFBCCC Shared Resources, including:

The Mission of the CGSR is to provide technical and analytical expertise in genomics research to facilitate high-impact translational science, basic research and clinical diagnostics.

We provide faculty with comprehensive and cost-competitive genetic analyses focused on:

  • Next-generation sequencing (NGS)
  • DNA microarray technologies
  • Bioinformatics solutions

Publication Highlights

  • Pardee, TS, Anderson, RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JW, Jin G, Zhang W, Ellis LR, Berenzon D, Howard DS, Hurd DD, Manuel M, Dralle S, Lyerly S, Powell BL.  A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia.  Clin Cancer Res. 2018 Feb 6. doi: 10.1158/1078-0432 CCR-17-2282 [Epub ahead of print].

  • Ma L, Chou JW, Snipes JA, Bharadwaj MS, Craddock AL, Cheng D, Weckerle A, Petrovic S, Hicks PJ, Hemal AK, Hawkins GA, Miller LD, Molina AJ, Langefeld CD, Murea M, Parks JS, Freedman BI.  APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction. J Am Soc Nephrol. 2017 Apr;28 (4):1093-1105
  • Miller LD, Chou JA, Black MA, Print C, Chifman J, Alistar A, Putti T, Zhou X, Bedognetti D, Hendrickx W, Pulikuth A, Rennhack J, Andrechek ER, Demaria S, Wang E, Marincola FM.  Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness.  Cancer Immunol Res. 2016 Jul;4(7):600-10.

  • Dewi FN, Wood CE, Willson CJ, REigster TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer Prev Res (Phila). 2016 May;9(5):385-95.

  • Levine EA, Votanopoulos KI, Qasem SA, Philip J, Cummins KA, Chou JW, Ruiz J, D'Agostino R, Shen P, Miller JD. Prognostic Molecular Subtypes of Low-Grade Cancer of the Appendix.  J. Am Coll Surg. 2016 Apr;222(4): 493-503.