The Bioinformatics Shared Resource (BISR) collaborates with clinical, cancer control, and basic science investigators to use genomics and informatics approaches in cancer research.

We help researchers:

  • Better understand the complex processes involved in the development and progression of various types of cancer, especially tobacco-related cancers
  • Use this knowledge to predict cancer recurrence, metastasis and response to therapies
  • Assign patients to specific targeted therapies, such as immunotherapies, to improve survival and quality-of-life

Our objectives for improving patient outcomes include:

  • Identifying germline and somatic genetic and epigenetic alterations that are associated with the development and progression of cancer
  • Identifying genetic and epigenetic events and mutation signatures in cancers caused by environmental factors, such as tobacco
  • Identifying ethnicity-related genetic and epigenetic alterations that may be underlying factors in health disparities
  • Utilizing genetic and epigenetic information for early detection of cancer (personalized risk prediction) and prediction of cancer recurrence and progression (personalized monitoring)
  • Promoting precision medicine (personalized intervention)
  • Understanding the functional mechanisms by which genetic and epigenetic findings have a direct effect on cancer