Every waking minute we have thoughts, we observe new things, we make decisions, we solve problems. How do these mental phenomena arise from the physical activity of neurons in the brain? This is the question our laboratory addresses.

The focus of our work in recent years has been the neural basis of working memory, the “sketchpad” of the mind, which allows us to represent information temporarily, in our train of thought. The techniques we use include neurophysiological recordings from multiple neurons in non-human primates, MRI and PET imaging, electrical stimulation, and computational analysis and modeling.

Questions we are actively pursuing include the roles of different cortical areas in working memory, the changes neural activity undergoes during adolescent development and in aging, and how working memory can be improved with training and deep brain stimulation.

Lab Members

Christos Constantinidis, PhD
Professor 

Xuelian Qi, PhD 
Instructor 

Saravanan Subramaniam, PhD
Postdoctoral Fellow 

Sihai Li
PhD Student

Junda Zhu
PhD Student 

Austin Lodish 
Lab Tech II 

Aquil Jones
Research Assistant 

Allie Persily 
Undergraduate Student

Macrae Robertson
Undergraduate Student 

Thomas Kellogg
Undergraduate Student 

Leonardo Silenzi
Undergraduate Student 

Rafael Mendoza
Undergraduate Student

Projects

Recent Publications

Differential Processing of Isolated Object and Multi-item Pop-Out Displays in LIP and PFC.. Meyers EM, Liang A, Katsuki F, Constantinidis C. Cereb. Cortex. 2018 Nov; 28(11):3816-3828.

Persistent Spiking Activity Underlies Working Memory.. Constantinidis C, Funahashi S, Lee D, Murray JD, Qi XL, Wang M, Arnsten AFT. J. Neurosci. 2018 Aug; 38(32):7020-7028.

Representation of Spatial and Feature Information in the Monkey Dorsal and Ventral Prefrontal Cortex.. Constantinidis C, Qi XL. Front Integr Neurosci. 2018; 12:31.

Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys.. Liu R, Crawford J, Callahan PM, Terry AV, Constantinidis C, Blake DT. Neuropharmacology. 2018 07; 137:202-210.

Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease.. Blake DT, Terry AV, Plagenhoef M, Constantinidis C, Liu R. Commun Integr Biol. 2017; 10(5-6):e1389359.