The Program includes molecular biologists from each of the basic science departments of the School of Medicine as well as clinical faculty involved in laboratory research.
Participating investigators include faculty from the departments of Biochemistry, Cancer Biology, Neurobiology and Anatomy, Medicine, Microbiology and Immunology, Pathology, Pediatrics, Physiology and Pharmacology, and Surgery.
The major focus of investigators in this area is the use of genetic and molecular approaches to study the underlying mechanisms of cancer and factors that contribute to tumor progression. Examples include identification of cancer susceptibility genes, genetic variation in tumor formation, DNA damage and repair pathways, and carcinogens.
Focus of the identification of molecular markers/targets that are specific to brain tumors. Faculty Profile & Publications
Research in our laboratory is directed towards applying advanced systems biology methodologies to i] investigate the timing of signaling events in the propagation of receptor tyrosine kinases signaling, ii] quantify the effect of oncogenic mutations or oxidation on the re-wiring of these signaling networks under pathogenic conditions, iii] apply clinical proteomics to identify molecular predictors of response to different cancer therapies in an effort to create personalized therapies; and iv] interface time-resolved mass spectrometry with microfluidics technology and develop new nanokinetics platforms for quantitative monitoring of rapid enzyme kinetics/drug screening assays to further our understanding of potential drug targets at molecular level.
My lab is interested in understanding how efficacious anti-cancer drugs cause cancer cell death and in designing new drugs and novel drug delivery strategies.
Cancer proteases play pivotal roles in the progression of cancer. Fatty Acid Synthase and prostate cancer: Fatty acid synthase (FAS) has been established as a biomarker and prognostic indicator for prostate cancer.
My research focus is directed at understanding how Acute Myeloid Leukemia cells resist chemotherapy with the hope of using this information to design clinical trials and improve outcomes for patients with this devastating disease.
Molecular mechanisms of mutagenesis during DNA replication in animal cells; use of in vitro model systems.
Mechanisms of resistance to cytotoxic and mutagenic agents; enzymes of glutathione metabolism; chemoprevention of cancer; oxidative stress and antioxidant defenses.
Studies in this area explore the contribution of specific genes to both physiologic and pathophysiologic processes. A major focus is on the experimental manipulation of genes and gene expression in animal models and cell-based systems and analyses of phenotypic consequences.
Molecular biological, electrophysiological, and behavioral approaches to study questions on long-term memory.
Virus assembly; molecular pathogenesis of virus infection.
Neutrophil biology and biochemistry; inflammation of lung; signal transduction; phospholipid metabolism; expression of IL-1, TNFa and cyclooxygenase genes in phagocytes.
Transcriptional and genomic alterations of the "oncogenome" that drive tumorigenesis and predict patient outcomes.
Neuronal development, degeneration, and plasticity after injury: identification and characterization of differentially expressed genes in motoneuron cell death.
New therapeutic targets for the treatment and prevention of SLE.
Hormonal controls of physiological processes with a focus on transcriptional controls of gene expression using genome wide and individual gene approaches to study cross talk between steroid hormones, leptin, and insulin in adipocyte cells and auxin and ethylene in Arabidopsis thaliana.
Research focuses on understanding the metabolic and hormonal adaptations to exercise and dietary interventions in older individuals, and the role of genetics in determining these adaptations.
Developmental neurobiology; programmed cell death; growth factors and neurotrophic molecules.
Molecular virology of adenovirus; the oncolytic and oncogenic potential of human adenovirus.
High-density lipoprotein metabolism, inflammation, atherosclerosis and insulin resistance.
Modulation of the expression of cytokines and connective tissue genes during early atherogenesis.
Regulation of apolipoprotein gene expression; structure-function relationships of apoprotein A-I.
Signal transduction; regulation of growth; hypertension; cancer treatment/prevention.
Labs: Hypertension Cell and Molecular Biology Laboratory
Structure and function of human apolipoprotein A-IV (apo A-IV), an intestinal protein synthesized during lipid absorption and incorporated into the surface of nascent chylomicrons.
The major focus of investigators in this area is the use of statistical analysis of genetic approaches.
Development and use of statistical methods in genetic epidemiology and longitudinal data.
Research focuses on the mapping of complex genetic traits.
Genetic epidemiology of metabolic diseases including type 2 diabetes, obesity and cardiovascular diseases.
Identification of genetic risk factors for cancer and prediction of individual risk of common diseases using genetic profiling.
The major focus of investigators in this area is the use of genetic approaches to identify genes that contribute to human disease. These include studies in families and populations and are facilitated by advanced, high-throughput technologies in combination with functional computational analysis.
Genetics of common diseases with emphasis on type 2 diabetes, cardiovascular disease, and renal disease.
Molecular genetics of human renal disease, diabetes mellitus and hypertension.
Molecular genetics of complex diseases.
Identification of genes for complex diseases, asthma and allergy.
Regulation of CD8+ cytotoxic T lymphocytes; control of functional avidity.
Vaccines against agents of bio-terrorism; flagellin signal transduction.
Molecular biology of paramyxoviruses.
The overall focus of my laboratory concerns the genetics of primary sex determination, germ cell development and fertility.
Stem and progenitor cell biology and genomics, molecular biology, angiogenesis
Mark Van Dyke
Genomics-guided biomaterials development, interaction of stem and progenitor cells with biomaterials, keratin biomaterials
Dr. Walker is broadly interested in using and developing molecular tools, especially array-based and sequencing technologies, to better understand transcriptional control that underlies development and disease processes.
Patricia G. Wilson
Stem cell biology, induced pluripotent stem cells (iPS cells), genetic reprogramming, molecular biology, neurodevelopment, stem cell-mediated neural repair and restoration of function.
Tissue engineering and clinical translation
Understanding protein-nucleic acid interactions at the molecular level.
Computational analysis of functional sites in proteins; development of methods to model biological networks from experimental time course data; and analysis of molecular dynamics and motion in proteins.
Molecular mechanisms of blood coagulation and fibrinolysis; conformation of proteins in solution.
X-ray crystallographic studies of DNA repair proteins and Fanconi anemia-associated proteins.
Nitrogen oxide signaling in hemoglobin and other heme proteins in normal physiology, disease and therapeutics using various spectroscopies including EPR, light scattering, and time-resolved absorption.
Analysis of protein structure and function using mass spectrometry, proteomics, and bioinformatics; proteolytic enzymes; cell biology and biochemistry of laryngopharyngeal reflux and gastroesophageal reflux disease.
X-ray crystallographic and biochemical analyses of enzymes that repair the oxidative damage to free and protein-incorporated methionine.
Enzymology of bacterial enzymes involved in defending against oxidative stress: enzymes that utilize flavin and cysteine residues at the catalytic site.
Mechanistic enzymology of bacterial enzymes involved in protection against oxidative stress; novel roles of catalytic cysteine residues.