Goyani S, Shukla S, Saranga MV, Mane M, Chandak N, Singh J, Jadiya P, Tomar D, Singh R. TRIM71 bound hsa-miR-30b-5p restores mitochondrial function in a cellular model of Parkinson's disease. Free Radic Biol Med. 2025 May 19;236:134-143. doi: 10.1016/j.freeradbiomed.2025.05.394. Online ahead of print. PMID: 40398685
Kashyap S, Jadiya P, Tomar D*. Enhancing VEGF therapy in T2D wounds with PLC?2 epigenetic targeting. Mol Ther. 2025 Feb 21:S1525-0016(25)00098-X.
N Damuka, RE Irmen, I Krizan, M Miller, K Gollapelli, B Bhoopal, O Deep, A Bansode, SN Lockhart, M Orr, P Jadiya, N Bashetti, JVS Kumar, A Mintz, CT Whitlow, S Craft, SL Macauley, KK Solingapuram Sai*; Exploring microtubule dynamics in AD: Longitudinal assessment using [11C]MPC-6827 PET imaging in rodent models of Alzheimer’s-related pathology”; Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 2024, 2024 Sep;20(9):6082-6093. PMID: 38967283
Garbincius JF, Luongo TS, Jadiya P, Hildebrand AN, Kolmetzky DW, Mangold AS, Roy R, Ibetti J, Nwokedi M, Koch WJ, Elrod JW. Enhanced NCLX-dependent mitochondrial Ca2+ efflux attenuates pathological remodeling in heart failure. J Mol Cell Cardiol. 2022 Jun;167:52-66. doi: 10.1016/j.yjmcc.2022.03.001. Epub 2022 Mar 28.
Vue Z, Murphy A, Le H, Neikirk K, Garza-Lopez E, Marshall AG, Mungai M, Jenkins B, Vang L, Beasley HK, Ezedimma M, Manus S, Whiteside A, Forni MF, Harris C, Crabtree A, Albritton CF, Jamison S, Demirci M, Prasad P, Oliver A, Actkins KV, Shao J, Zaganjor E, Scudese E, Rodriguez B, Koh A, Rabago I, Moore JE, Nguyen D, Aftab M, Kirk B, Li Y, Wandira N, Ahmad T, Saleem M, Kadam A, Katti P, Koh HJ, Evans C, Koo YD, Wang E, Smith Q, Tomar D, Williams CR, Sweetwyne MT, Quintana AM, Phillips MA, Hubert D, Kirabo A, Dash C, Jadiya P, Kinder A, Ajijola OA, Miller-Fleming TW, McReynolds MR, Hinton A Jr. MICOS Complex Loss Governs Age-Associated Murine Mitochondrial Architecture and Metabolism in the Liver, While Sam50 Dictates Diet Changes. bioRxiv. 2024 Jul 3;. doi: 10.1101/2024.06.20.599846. PubMed PMID: 38979162; PMCID: PMC11230271.
Vue Z, Prasad P, Le H, Neikirk K, Harris C, Garza-Lopez E, Wang E, Murphy A, Jenkins B, Vang L, Scudese E, Shao B, Kadam A, Shao J, Marshall AG, Crabtree A, Kirk B, Koh A, Wilson G, Oliver A, Rodman T, Kabugi K, Koh HJ, Smith Q, Zaganjor E, Wanjalla CN, Dash C, Evans C, Phillips MA, Hubert D, Ajijola O, Whiteside A, Do Koo Y, Kinder A, Demirci M, Albritton CF, Wandira N, Jamison S, Ahmed T, Saleem M, Tomar D, Williams CR, Sweetwyne MT, Murray SA, Cooper A, Kirabo A, Jadiya P, Quintana A, Katti P, Fu Dai D, McReynolds MR, Hinton A Jr. The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney. bioRxiv. 2024 Jun 12;. doi: 10.1101/2024.06.09.598108. PMID: 38915644; PMCID: PMC11195114.
Jadiya P, Kolmetzky DW, Tomar D, Thomas M, Cohen HM, Khaledi S, Garbincius JF, Hildebrand AN, Elrod JW. Genetic ablation of neuronal mitochondrial calcium uptake halts Alzheimer's disease progression. bioRxiv, 2023.10. 11.561889
Garbincius JF, Luongo TS, Lambert JP, Mangold AS, Murray EK, Hildebrand AN, Jadiya P, Elrod JW.MCU gain-and loss-of-function models define the duality of mitochondrial calcium uptake in heart failure.bioRxiv. 2023 Apr 18:2023.04.17.537222. doi: 10.1101/2023.04.17.537222. Preprint. PMID: 37131819.
Jadiya P, Cohen HM, Kadam A, Kolmetzky DW, Tomar D, and Elrod JW. Neuronal Loss of NCLX-Dependent Mitochondrial Calcium Efflux Contributes to Age-Associated Cognitive Decline. iScience 2023 Feb 28;26(3):106296. PMID: 36936788.
Tomar D, Thomas M, Garbincius J, Kolmetzky DK, Salik O, Jadiya P, Joseph S, Carpenter A, György Hajnóczky G, John W. Elrod.MICU1 regulates mitochondrial cristae structure and function independently of the mitochondrial Ca2+ uniporter channel. Science Signaling, 2023 Apr 25;16(782):eabi8948
Jadiya P, Kolmetzky DW, Tomar D, Thomas M, Khaledi S, Garbincius JF, Hildebrand AN, and Elrod JW. 2021. Genetic Ablation of Neuronal Mitochondrial Calcium Uptake Halts Alzheimer's Disease Progression. Available at SSRN: https://ssrn.com/abstract=3872940 or http://dx.doi.org/10.2139/ssrn.3872940 Preprint
Agustín P, Foces C, Romero SC, Ramos E, Oliva T, Piña V, Moreno L, Álvarez A, J. García D, Vieco L, Jadiya P, Navarro E. et al. 2020. Na + controls hypoxic signalling by the mitochondrial respiratory chain. Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2551-y.
Haque R, Shamsuzzama, Kumar L, Sharma T, Fatima S, Jadiya P, Siddiqi MI, Nazir A. Human insulin modulates α-synuclein aggregation via DAF-2/DAF-16 signalling pathway by antagonising DAF-2 receptor in C. elegans model of Parkinson's disease. Oncotarget. 2020 Feb 11;11(6):634-649.
Saxena R, Saribas S, Jadiya P, Tomar D, Elrod J, Safak M. Human Neurotropic Polyomavirus, JC virus, Agnoprotein Targets Mitochondrion and Modulates its Functions. Virology 2020 Nov 25, DOI: 10.1016/j.virol.2020.11.004
Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Lorkiewicz PK, Hajnóczky G, Murphy E, Hill BG, Elrod JW. Mitochondrial Calcium Exchange links Metabolism with the Epigenome to Control Cellular Differentiation. Nature Communications. 2019 Oct 4;10(1):4509.
Research Covered in news portals: Temple Health News; ScienceDaily; MedicalXpress; The Medical News; MedIndia
Lambert JP, Luongo TS, Tomar D, Jadiya P, Gao E, Zhang X, Lucchese AM, Kolmetzky DW, Shah NS, Elrod JW. MCUB regulates the molecular composition of the mitochondrial calcium uniporter channel to limit mitochondrial calcium overload during stress. Circulation. 2019 Nov 19;140(21):1720-1733.
Research Covered in news portals: Temple Health News; ScienceDaily; WeatherHerald; LongRoom
Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW. Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease. Nature Communications. 2019 Aug 29;10(1):3885.
Research Covered in news portals: ScienceDaily; LongRoom; Temple Health News; WeatherHerald; Biospace; The Medical News; MedicalXpress
Tomar D, Thomas M, Garbincius JF, Kolmetzky DW, Salik O, Jadiya P, Carpenter AC, and Elrod JW. MICU1 regulates mitochondrial cristae structure and function independent of the mitochondrial calcium uniporter channel. bioRxiv, 2019 Oct 12; 803213. doi: https://doi.org/10.1101/803213 Preprint
Tomar D, Jaña F, Dong Z, Quinn III WJ, Jadiya P, Breves SL, Daw CC, Srikantan S, Shanmughapriya S, Nemani N, Carvalho E, Tripathi A, et al. Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation. Cell Reports. 2019 Mar 26;26(13):3709-3725.e7.
Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL. Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Cell Reports. 2018 Jun 26;23(13):3710-3720.e8.
Jadiya P, Mir SS, Nazir A. Osmotic stress induced toxicity exacerbates Parkinson's associated effects via dysregulation of autophagy in transgenic C. elegans model. Cellular Signaling. 2018 May; 45:71-80.
Kumar L, Shamsuzzama, Jadiya P, Haque R, Shukla S, Nazir A. Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease. Molecular Neurobiology. 2018 Aug;55(8):6914-6926.
Jadiya P, Fatima S, Baghel T, Mir SS and Nazir A. A Systematic RNAi Screen of Neuroprotective Genes Identifies Novel Modulators of α-synuclein- Associated Effects in Transgenic C. elegans. Molecular Neurobiology. 2016 Nov;53(9):6288-6300.
Seki M, LaCanna R, Powers JC, Vrakas C, Liu F, Berretta R, Chacko G, Holten J, Jadiya P, Wang T, Arkles JS, Copper JM, Houser SR, Huang J, Patel VV, Recchia FA. Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation. J Pharmacol Exp Ther. 2016 Sep;358(3):441-9.
Tsai WC, Chan YH, Hsueh CH, Everett TH 4th, Chang PC, Choi EK, Olaopa MA, Lin SF, Shen C, Kudela MA, Rubart-von der Lohe M, Chen Z, Jadiya P, Tomar D, Luvison E, Anzalone N, Patel VV, Chen PS. Small conductance calcium-activated potassium current and the mechanism of atrial arrhythmia in mice with dysfunctional melanocyte-like cells. Heart Rhythm. 2016 Jul;13(7):1527-35.
Safia, Kamil M, Jadiya P, Sheikh S, Haque E, Nazir A, Lakshmi V, Mir SS. The Chromone Alkaloid, Rohitukine, Affords Anti-Cancer Activity via Modulating Apoptosis Pathways in A549 Cell Line and Yeast Mitogen Activated Protein Kinase (MAPK) Pathway. PLoS One. 2015 Sep 25;10(9):e0137991.
Fatima S, Haque R, Jadiya P, Shamsuzzama, Kumar L, Nazir A. Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and Diabetes: role of Daf-2/Daf-16 insulin like signalling pathway. PLoS One. 2014 Dec 3;9(12):e113986.
Sashidhara KV, Modukuri RK, Jadiya P, Rao KB, Sharma T, Haque R, Singh DK, Banerjee D, Siddiqi MI, Nazir A. Discovery of 3-Arylcoumarin-tetracyclic Tacrine Hybrids as Multifunctional Agents against Parkinson's Disease. ACS Medical Chemistry Letters. 2014 Aug 20;5(10):1099-103.
Sashidhara KV, Modukuri RK, Jadiya P, Dodda RP, Kumar M, Sridhar B, Kumar V, Haque R, Siddiqi MI, Nazir A. Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. ChemMedChem. 2014 Dec;9(12):2671-84.
Jadiya P, and Nazir A. A pre- and co-knockdown of RNAseT enzyme, Eri-1, enhances the efficiency of RNAi induced gene silencing in Caenorhabditis elegans. PLoS One. 2014 Jan 24;9(1):e87635.
Jadiya P, and Nazir A. Environmental toxicants as extrinsic epigenetic factors for Parkinsonism: Studies employing transgenic C. elegans model. CNS Neurol Disord Drug Targets. 2012 Dec;11(8):976-83.
Jadiya P, Mir SS, and Nazir A. Effect of various classes of pesticides on expression of stress genes in transgenic C. elegans model of Parkinson's disease. CNS Neurol Disord Drug Targets. 2012 Dec;11(8):1001-5.
Kaur S, Sammi SR, Jadiya P, Nazir A. RNAi of cat-2, a putative tyrosine hydroxylase, increases alpha synuclein aggregation and associated effects in transgenic C. elegans. CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):387-94.
Jadiya P, Chatterjee M, Sammi SR, Kaur S, Palit G, and Nazir A. Sir-2.1 modulates 'calorie-restriction-mediated' prevention of neurodegeneration in Caenorhabditis elegans: implications for Parkinson's disease. Biochem Biophys Res Commun. 2011 Sep 23;413(2):306-10.
Jadiya P, Khan A, Sammi SR, Kaur S, Mir SS, and Nazir A. Anti-Parkinsonian effects of Bacopa monnieri: insights from transgenic and pharmacological Caenorhabditis elegans models of Parkinson's disease. Biochem Biophys Res Commun. 2011 Oct 7;413(4):605-10.
Review Articles/Book Chapters
Goyani S, Shukla S, Jadiya P*, Tomar D*. Calcium signaling in mitochondrial intermembrane space. Biochem Soc Trans. 2024 Oct 30;52(5):2215-2229.
Raghav D, Shukla S, Jadiya P*. Mitochondrial calcium signaling in non-neuronal cells: Implications for Alzheimer's disease pathogenesis. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15;1870(5):167169
Kadam A, Jadiya P*, Tomar D*. Post-translational modifications and protein quality control for mitochondrial channels and transporters. Frontiers in Cell and Developmental Biology, section Molecular and Cellular Pathology. Volume 11 - 2023 | doi: 10.3389/fcell.2023.1196466.
Jadiya P, Garbincius JF, Elrod JW. Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling. Acta Neuropathologica Communications 2021, 9, 124. https://doi.org/10.1186/s40478-021-01224-4 Review
Klionsky D,..Jadiya P, et al. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition). Autophagy 2020.DOI:10.1080/15548627.2020.1797280. Review
Jadiya P*, Tomar D*. Mitochondrial Protein Quality Control Mechanisms. Genes 2020, 11, 563. doi:10.3390/genes11050563. *Corresponding author Feature Paper Review
Gnaiger E,.. Jadiya P, et al. MitoEAGLE Task Group. Mitochondrial physiology. Bioenergetics Communications 2020.1. https://doi:10.26124/bec:2020-0001.v1. Review
Jadiya P*, Tomar D*. Calcium and Bioenergetics. (February 2018) eLS: Wiley: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0027818. *Corresponding author Book Chapter