Selected Publications
MICU1 regulates mitochondrial cristae structure and function independent of the mitochondrial calcium uniporter channel.
Tomar D, Thomas M, Garbincius JF, Kolmetzky DW, Salik O, Jadiya P, Joseph SK, Carpenter AC, Hajnóczky G, Elrod JW. Science Signaling. 2023 Apr 25;16(782):eabi8948.
Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart.
Wang JF, Tomar D, Martin TG, Dubey S, Dubey PK, Song J, Landesberg G, McCormick MG, Myers VD, Merali S, Merali C, Lemster B, McTiernan CF, Khalili K, Madesh M, Cheung JY, Kirk JA, Feldman AM. J Am Coll Cardiol Basic Trans Science. Apr 19, 2023. Epublished DOI: 10.1016/j.jacbts.2022.12.013
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
Jadiya P, Cohen HM, Kolmetzky DW, Kadam AA, Tomar D, Elrod JW. iScience. 2023 Feb 28;26(3):106296.
MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress
Lambert JP, Luongo TS, Tomar D, Jadiya P, Gao E, Zhang X, Lucchese AM, Kolmetzky DW, Shah NS, Elrod JW. Circulation. 2019 Nov 19;140(21):1720-1733. doi: 10.1161/CIRCULATIONAHA.118.037968.
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease
Jadiya P, Kolmetzky DW, Tomar D, Di Meco A, Lombardi AA, Lambert JP, Luongo TS, Ludtmann MH, Praticò D, Elrod JW. Nat Commun. 2019 Aug 29;10(1):3885. doi: 10.1038/s41467-019-11813-6.
Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation
Tomar D, Jaña F, Dong Z, Quinn III WJ, Jadiya P, Breves SL, Daw CC, Srikantan S, Shanmughapriya S, Nemani N, Carvalho E, Tripathi A, Worth AM, Zhang X, Razmpour R, Seelam A, Rhode S, Mehta AV, Murray M, Slade D, Ramirez SH, Mishra P, Gerhard GS, Caplan J, Norton L, Sharma K, Rajan S, Balciunas D, Wijesinghe DS, Ahima RS, Baur JA, Madesh M. Cell Reports. 2019 Mar 26;26(13):3709-3725.e7. doi: 10.1016/j.celrep.2019.02.107.
MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress
Nemani N*, Carvalho E*, Tomar D*, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M. Cell Reports. 2018 Apr 24;23(4):1005-1019. doi: 10.1016/j.celrep.2018.03.098. *equal first authors
Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals
Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. JAMA Cardiol. 2018 Oct 1;3(10):929-938. doi: 10.1001/jamacardio.2018.2541.
Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity
Dong Z*, Shanmughapriya S*, Tomar D*, Siddiqui N, Lynch S, Nemani N, Breves SL, Zhang X, Tripathi A, Palaniappan P, Riitano MF, Worth AM, Seelam A, Carvalho E, Subbiah R, Jaña F, Soboloff J, Peng Y, Cheung JY, Joseph SK, Caplan J, Rajan S, Stathopulos PB, Madesh M. Molecular Cell. 2017 Mar 16;65(6):1014-1028.e7. doi: 10.1016/j.molcel.2017.01.032. *equal first authors
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics
Tomar D*, Dong Z*, Shanmughapriya S*, Koch DA*, Thomas T, Hoffman NE, Timbalia SA, Goldman SJ, Breves SL, Corbally DP, Nemani N, Fairweather JP, Cutri AR, Zhang X, Song J, Jaña F, Huang J, Barrero C, Rabinowitz JE, Luongo TS, Schumacher SM, Rockman ME, Dietrich A, Merali S, Caplan J, Stathopulos P, Ahima RS, Cheung JY, Houser SR, Koch WJ, Patel V, Gohil VM, Elrod JW, Rajan S, Madesh M. Cell Reports. 2016 May 24;15(8):1673-85. doi: 10.1016/j.celrep.2016.04.050. *equal first authors
TRIM4; a novel mitochondrial interacting RING E3 ligase, sensitizes the cells to hydrogen peroxide (H2O2) induced cell death
Tomar D, Prajapati P, Lavie J, Singh K, Lakshmi S, Bhatelia K, Roy M, Singh R, Bénard G, Singh R. Free Radic Biol Med. 2015 Dec;89:1036-48. doi: 10.1016/j.freeradbiomed.2015.10.425.
TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death
Tomar D, Prajapati P, Sripada L, Singh K, Singh R, Singh AK, Singh R. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2013 Dec;1833(12):3134-3144. doi: 10.1016/j.bbamcr.2013.08.021.