Tao Ma Lab - Recent Publications

Selective Publications (from 50+ peer-reviewed publications)

Zhou X, Yang W, Wang X, and Ma T. Brain-specific repression of the α1 isoform of AMP-activated protein kinase alleviates object recognition impairments in aged mice. Aging. 2023 Feb 26;15(4):932-946. PMID: 36842095.

Kasica NP, Zhou X, Wang X, Yang W, Zimmermann HR, Holland CE, Koscielniak E, Wu H, Cox AO, Lee J, Ryazanov AG, Furdui CM, and Ma T. Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice. J Neurochem. 2022; 160:524-539. PubMed PMID: 34932218. Cover article with editorial highlights.

Yang W, Zhou X, Zimmermann HR, Ma T. Brain-specific suppression of AMPKα2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2α phosphorylation. 2021, Mol Psychiatry. 26: 1880-1897. PMID: 32366952

Wang X, Zhou X, Uberseder B, Lee J, Latimer CS, Furdui CM, Keene CD, Montine TJ, Register TC, Craft S, Shively CA, Ma T. Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease. Neurobiol Dis. 2021, Oct; 158:105463. PMID: 34363967.

Zimmermann HR, Yang W, Kasica NP, Zhou X, Beckelman BC, Lee J, Furdui CM, Keene CD, Ma T. Brain-specific repression of AMPKα1 isoform alleviates pathophysiology in Alzheimer's disease model mice. 2020, J Clin Invest. 130:3511-3527. PMID: 32213711. (Editor's picks of the month, featured in "JCI This Month").

Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T (2019). Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019 Feb 1; 129:820-833. PMID: 30667373.

Zimmermann HR, Yang W, Beckelman BC, Kasica NP, Zhou X, Galli L, Ryazanov AG, Ma T (2018) Genetic Removal of eIF2α Kinase PERK in Mice Enables Hippocampal L-LTP Independent of mTORC1 Activity. J Neurochem. 146: 133-144. PMID: 29337352. Cover article with editorial highlight.

Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E (2014) Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β. J Neurosci 34: 12230-12238 (paper of the week). PMID: 25186765.

Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E (2013) Suppression of PERK-eIF2α signaling alleviates synaptic plasticity and spatial memory deficits in Alzheimer's disease model mice. Nat Neurosci. 16:1299-1305. PMID: 23933749.

Ma T, Du X, Pick J, Sui G, Brownlee M, Klann E (2012) Glucagon-like peptide-1 cleavage product GLP-1 (9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's Disease model mice. J Neurosci. 32: 13701-13708 (paper of the week). PMID: 23035082.

Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD (2011) Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci 31: 17537-17546 (cover paper). PMID: 22131415.