Patients with virtually any type of cancer have the opportunity to participate in one of nearly 250 research studies conducted by oncologists from the Wake Forest Baptist Comprehensive Cancer Center or by one of the other leading cancer researchers around the country with whom we collaborate.

Most of the studies combine conventional treatments such as surgery, radiation therapy and chemotherapy, with novel molecular therapeutic approaches.

Our Cancer Center also utilizes integrative approaches with complementary and alternative medicines, including vitamin and nutritional therapies, in both cancer treatment and symptom management research. We firmly believe that “research cures cancer” and so do the 1,000 or more of our patients per year who enroll in one or more of our innovative clinical trials. These trials originate from the Cancer Center or one of the national Cooperative Groups of which we are a member:

In addition, WFBCCC is a National Cancer Institute (NCI) funded Community Oncology Research Program (NCORP) Research Base, the only NCI-designated Comprehensive Cancer Center Research Base. As such, it provides a conduit for community physicians to participate in NCI-supported trials, giving their patients enhanced access to high-quality research studies in their own communities. Currently, about 30 community sites located across the United States participate in cancer treatment and symptom management studies.

These studies address important issues such as:

  • Treatment-related fatigue
  • Weight loss
  • Hot flashes
  • Depression
  • Cognitive function
  • Nutrition in cancers of the brain, breast, cervix, head and neck, lung, ovary and prostate
  • Soft tissue sarcomas
  • Metastatic disease

The major goal of the Clinical Research Program (CRP) of the WFBCCC is to serve as a hypothesis-driven incubator and catalyst for the clinical translation of novel therapeutic, diagnostic, and supportive care strategies.

This goal is achieved by:

  • Translating advances in the understanding of cancer from the WFBCCC’s basic sciences and population science Programs into novel therapeutic strategies with correlative biomarkers of response.
  • Promoting the development and conduct of innovative clinical trials for rare or difficult to treat cancers and sites of metastasis.
  • Enhancing understanding in cancer-related symptom science, including leveraging the Wake Forest National Cancer Institute Community Oncology Program Research Base.

CRP research is comprised of two themes within these aims: experimental therapeutics and addressing health disparities, with particular focus on cancers of high incidence in the WFBCCC catchment area.

Scientific Focus

The Clinical Research Program of the WFBCCC has 3 Specific Aims: