The laboratory of Chris Peters, MD, is focused on addressing chronic pain after surgery. Chronic pain after surgery (CPAS) is now recognized as a major public health concern that can affect between 10 and 50 percent of patients depending on the type of surgery. Currently, there is no standard of medical care provided perioperatively to prevent CPAS.

Research Project Highlights

The ultimate goal of our research is to identify Food and Drug Administration (FDA)-approved and novel therapeutic approaches for preventing CPAS to introduce into clinical studies.

Our current projects include:

  • Modeling observations in rodents that patients with diminished preoperative endogenous pain inhibition are at greater risk for developing CPAS.
  • How disrupting spinal noradrenergic signaling influences spinal neural and glial plasticity promoting the transition from acute to a more persistent postoperative pain state.
  • Monitoring postoperative pain-related behaviors over time using mixed effects growth curve modeling, allowing us to examine the ability of socio-environmental conditions or pharmacological interventions to impair or improve several aspects of postoperative pain trajectory.