The Pain Mechanisms Lab began with a collaboration between Dr. James Eisenach and Tony Yaksh nearly 25 years ago, and has now grown to a vibrant group of investigators, post-doctoral fellows, students and technicians. Throughout that time the core values of the laboratory have remained the same—to be a place of education and excited learning as we explore the translational science of pain and its treatment. We learn together through regular meetings, both formal and informal.

Pain Mechanisms LabDr. Eisenach’s role as director of the laboratory is to foster these interactions, understand the career goals of all individuals in the laboratory and assure that the experience of everyone here meets those goals. While graduate students, postdocs, and research fellows are mentored by a primary Principal Investigator, the approach to most programs is team-based.

This is a friendly place doing great science. We have brought five new non-opioid analgesic therapies from discovery to human clinical trials, including one that is Food and Drug Administration (FDA)-approved and the most commonly used non-narcotic spinal drug in the treatment of neuropathic pain. At nearly every meeting we discuss clinical needs and potential clinical application of our work, and most fellows interact with clinician investigators to test some aspects in humans of the work they perform in the lab.