Cancer Genome Mutational Landscapes

Our group was the first group to use multidimensional scaling method to cluster glioma based on trasndcriptome. We also built the first comprehensive tissue microarray in glioma.

Since the establishment of TCGA, our group has been actively involved in working groups for glioblastoma, low-grade glioma, colorectal, breast, bladder, kidney, gastric and endometrial cancers. We co-authored >10 N Eng J Med, Nature, Cell, and Nature Genetics papers reporting these studies.

Our discovery of an aggressive form of endometrioid endometrial cancer characterized by beta-catenin mutation and Wnt pathway activation was published in Journal of National Cancer Institute (2014 Sep 10;106(9).). I am a leader of a US-China consortium investigating mutation profiles in gastric cancers in a Chinese population (PNAS 2015 Jan 27;112(4):1107-12.). Our group continues the effort in interrogating the cancer genome landscape and its impact on prognosis and therapy.

Selected Research

Liu Y, Patel L, Mills G, Lu K, Sood A, Ding L, Kucherlapati R, Mardis E, Levine D, Shmulevich I, Broaddus R, and Zhang W. Clinical Significance of CTNNB1 Mutation and Wnt Pathway Activation in Endometrioid Endometrial Carcinoma. J Natl Cancer Inst. 2014 Sep 10;106(9).

Chen K, Yang D, Li X, Sun B, Song F, Cao W, Brat D, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce C, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo L, Cavenee W*, Zhang W*, Hao X*. Mutational Landscape of Gastric Adenocarcinoma in Chinese: Implications for Prognosis and Therapy. Proc Natl Acad Sci USA 112: 1107–1112, 2015 *Corresponding authors