Clinical research is a core mission of CIIRRC. This mission spans the full spectrum of care from pre-hospital (EMS) to acute and critical care and post-hospital care (rehabilitation and outpatient visits) and the full spectrum of science from bench research to bedside, back to bench and finally to the community.
Collaborations
CIIRRC is building and implementing multidepartmental and transdisciplinary science teams within and beyond the Wake Forest academic enterprise.
These teams help:
- Attract and train new basic and clinical investigators
- Engage local and national communities
- Implement discovery into best medical practices
- Advance health policies with a strong emphasis on cutting-edge clinical trials.
Fostering translational collaborations spanning the spectrum from basic science research to clinical and population based research and has created several multi-investigator teams. Transdisciplinary collaborations through CIIRRC succeeded in joining NIH PETAL Network, participation in USCIIT, procuring and maintaining collaborative R01s, and advancing industry funded clinical trials.
Collaborations between CIIRRC and other centers and research areas include:
- Aging (Sticht Center on Aging)
- Center on Diabetes, Obesity and Metabolism
- Comprehensive Cancer Center
- Wake Forest Institute for Regenerative Medicine
- Maya Angelou Center for Health Equity
Funding Opportunities
Current funding includes the PETAL grant administered by the National Institutes of Health’s National Heart, Lung, Blood Institute (NHLBI) with $80 million dollars directed towards this initiative across 12 primary institutions
The National Institutes of Health’s National Heart, Lung, Blood Institute (NHLBI) has directed $80 million dollars to this initiative. PETAL stands for Prevention and Early Treatment of Acute Lung Injury. This is a national network and through a competitive grant process, 12 primary academic institutions were selected, one of which was Wake Forest. Each of the primary institutions coordinates two to four other sites to enroll patients into studies over the seven years of the award. Wake Forest co-sites include University of Kentucky, University of Virginia and Virginia Commonwealth University.
This network has as its focus, the treatment of those individuals who may be at risk to develop significant lung dysfunction. Experts from Emergency Medicine, Surgery and Medicine are involved nationally. At Wake Forest, the investigators include Chad Miller (Emergency Medicine), Jason Hoth (Trauma-Acute General Surgery), and Clark Files (Pulmonary-Critical Care).
Sponsor: National Institutes of Neurologic Disorders and Stroke (NINDS)
Project Dates: 9/30/2012 - 8/31/2017
Principal Investigator: Brown,Candice M
Title: 2R01AI065791-06 - “NF-kB and Chromatin Changes in Human Sepsis”
Sponsor: NIH
Project Dates: 7/1/2005 - 2/29/2016
Principal Investigator: McCall,Charles E
Title: TLR4-Dependent Reprogramming of Translation Regulates Acute Systemic Inflammation
Sponsor: s/East Tennessee State University
Project Dates: 36/1/2014 - 2/28/2015
Principal Investigator: McCall,Charles E
Title: Mitochondrial Biogensis is Regulated by ReIB During Inflammation
Sponsor: National Institute of General Medicine Sciences (NIGMS)
Project Dates: 8/15/14 – 4/30/2015
Principal Investigator: McCall,Charles E
Title: R01GM103887 “MicroRNAs and Myeloid Cell Development During Sepsis”
Sponsor: NIH
Project Dates: 9/13/2013 - 5/31/2018
Principal Investigator: McCall,Charles E
Title: R01 HL118263 “CMR-IMPACT”
Sponsor: Department of Health & Human Service – NIH
Project Dates: 6/5/2013 - 5/31/2018
Principal Investigator: Miller,Chadwick David
Title: Crash Simulation Using the Total Human Model for Safety (Toyota Crash Simulation)
Sponsor: Toyota
Project Dates: 9/1/2011 - 2/28/2016
Principal Investigator: Stitzel Jr.,Joel Douglas
Title: Warrior Injury Assessment Manikin (WIAMan) Biomechanics Product Team (BIO PT)
Sponsor:
Project Dates: 5/1/2013 - 2/28/2017
Principal Investigator: Stitzel Jr.,Joel Douglas
Mentorship and Pilot Grants
CIIRRC fosters early-career researchers into established investigators through mentorship and pilot grants. Junior faculty seeking training grants and development funding receive the support and mentorship of established researchers within CIIRRC. CIIRRC also sponsors pilot grants yearly with the goal of fostering new collaborations and developing multidisciplinary teams. It is the goal that these pilot projects lead to highly competitive K or R01 applications.