Xuewei Zhu, PhD

Associate Professor, Molecular Medicine

Research Interests

Macrophages
Sepsis
Autophagy
Immunometabolism
Inflammasome
Glucose Metabolism

I study the molecular basis of immunometabolism, macrophage inflammation and cell death, as well as the role of immunometabolism in chronic metabolic diseases and acute inflammatory diseases. See the Zhu Lab for more information.

Education Program Involvement

Molecular Medicine and Translational Science PhD
Program Research Interest: Analytical approaches to molecular and cellular synthesis, structure and function, Genetics and gene regulation, Cell communications, Organ systems, Pathophysiology

Education: PhD, 2005; PhD, Peking Union Medical College Hospital (PUMCH), 2005
Memberships: AHA - Council on Arteriosclerosis; Society for Leukocyte Biology
Positions: Associate Professor, Molecular Medicine; Associate Professor, Microbiology and Immunology
Departments and Affiliations: Molecular Medicine; Microbiology and Immunology; Cardiovascular Sciences Center; Center for Precision Medicine; Center for Redox Biology and Medicine; Center on Diabetes, Obesity, and Metabolism; Sticht Center for Healthy Aging and Alzheimer’s Prevention

Research

Publications

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation. Meyers AK, Wang Z, Han W, Zhao Q, Zabalawi M, Duan L, Liu J, Zhang Q, Manne RK, Lorenzo F, Quinn MA, Song Q, Fan D, Lin HK, Furdui CM, Locasale JW, McCall CE, Zhu X. Cell Rep. 2023 Jan; 42(1):111941.
Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats. Gharraee N, Wang Z, Pflum A, Medina-Hernandez D, Herrington D, Zhu X, Meléndez GC. J Lipid Res. 2022 Nov; 63(11):100292.
SMGR: a joint statistical method for integrative analysis of single-cell multi-omics data. Song Q, Zhu X, Jin L, Chen M, Zhang W, Su J. NAR Genom Bioinform. 2022 Sep; 4(3):lqac056.
Sepsis, pyruvate, and mitochondria energy supply chain shortage. McCall CE, Zhu X, Zabalawi M, Long D, Quinn MA, Yoza BK, Stacpoole PW, Vachharajani V. J Leukoc Biol. 2022 Dec; 112(6):1509-1514.
Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates Atherosclerosis in LDL Receptor-Deficient Mice. Zhao Q, Wang Z, Meyers AK, Madenspacher J, Zabalawi M, Zhang Q, Boudyguina E, Hsu FC, McCall CE, Furdui CM, Parks JS, Fessler MB, Zhu X. Front Cardiovasc Med. 2021; 8:777098.

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Research Interests

Autophagy
Cardiovascular Diseases
Glucose Metabolism
Immunometabolism
Inflammasome
Innate Immunity
Lipid Metabolism
Macrophages
Obesity and Type 2 Diabetes
Sepsis

Technology Transfer and Commercialization

Research Focus Areas

Translation to Care

More Resources

Xuewei Zhu, PhD

Research Interests

Education Program Involvement