Orthopaedic Surgery Research Initiatives

Clinical faculty: Koman, Li, Tuohy, Wiesler
Basic science faculty: TL Smith, Danelson
Residents: 
Outside collaborators: J Foxworth, Molnar

• peripheral nerve
  • repair
  • peripheral nervous system response to injury
    • schwann cell activation
    • macrophage recruitment
    • biological augmentation with growth factor supplementation
  • physiology and aging
  • nerve regeneration: keratin, biomaterials, acellual nerve allografts plus aniotic stem cells
  • nerve-muscle interactions and the neuromuscular junction

• rotator cuff
  • rodent model
  • mathematical modeling
  • biology of aging
  • human upper-extremity movement biomechanics

• botulinum neurotoxin biology, spasticity and myoneural physiology
  • therapeutic applications of botulinum neurotoxin in orthopaedic surgery
  • mathematical modeling of muscle function

• microangiology
  • thermoregulatory mechanisms
  • novel therapies for Raynaud's phenomena, lupus and vascular insufficiency of the upper extremity

• multicenter trial of keratin biomaterials for peripheral nerve regeneration (United States Department of Defense-funded)
• rat model for studying brachial plexus birth palsy
• clinical trial for the surgical treatment of distal radius fractures in the elderly (National Institutes of Health multicenter trial; University of Michigan Medical School, coordinating center)

Clinical faculty: Ferguson, Hubbard, Martin, Poehling, Stubbs
Basic science faculty: TL Smith
Residents:
Outside collaborators: J Foxworth (WSSU), Kate Saul (NC State)

• meniscus repair/tissue engineering
• meniscus and osteoarthritis
  • human
  • rodent
• tendon/ligament repair
  • tissue engineering
  • ACL repair and biology
  • rotator cuff regenerative medicine
• rotator cuff
  • rodent model
  • mathematical modeling
  • biology of aging
  • human upper-extremity movement biomechanics
• VCAM-1 molecular marker for tracking and profiling premature human hip osteoarthritis
• effect of hip orthroses on balance in post-operative hip arthroscopy patients
• painful hip joint in younger patients
• outcomes of hip arthroscopy
• uniportal versus two-portal techniques for knee arthroscopy

Clinical faculty: Carroll, Halvorson, Miller, Scott, Teasdall
Basic science faculty: TL Smith, Danelson
Outside collaborators: JD Stitzel, D Carroll, N Levi, W Wagner, M Morykwas

• outcomes of pelvic and acetabular fractures
• topical negative pressure and tissue viability
• compartment syndrome
  • nanotechnology pressure monitoring
• bone biology
  • healing
  • regenerative medicine
• biomechanics of foot and ankle
  • Achilles tendon fixation
  • ORIF of foot fractures
• advanced radiological imaging modalities for improved diagnosis, treatment and education
• Major Extremity Trauma Research Consortium (METRC); Core Center (Department of Defense-funded)

Clinical faculty: Lang, Langfitt, Shields, Stubbs, Poehling, Bullock
Basic science faculty: Danelson
Residents:
Outside collaborator: J Foxworth

• knee kinematics and biomechanics
  • patellar tracking
  • cadaveric studies and implant design
  • gait analysis and movement biomechanics following total joint replacement
• hip preservation
  • arthroscopy and biology of degenerative changes
  • early detection and surveillance of arthritic changes
  • proprioceptive changes after hip arthroscopy
• hip surgery
  • finite element analysis of the femur
• outcomes of total joint replacement
• unicompartmental knee arthroplasty

Clinical faculty: Ferguson, Koman, Li, Tuohy
Basic science faculty: TL Smith
Residents: Bracey, Marquez-Lara
Outside collaborators: D Carroll, L Burnett

• stem cell applications and growth factor/biological augmentation in orthopaedic surgery
  • adipose derived stem cells
  • bone marrow derived stem cells
  • platelet enriched plasma
• decellularization/oxidation/sterilization of tissues for scaffolds
  • tendons/ligaments
  • meniscus
  • bone
• keratin biomaterials
  • resuscitation fluids for treatment of trauma patients
  • management of burn injury
  • homeostasis
  • nerve regeneration
• effect of NSAIDs on fracture healing

Clinical faculty: Gyr, Frino, Kolaski, Koman
Basic science faculty:
Outside collaborator: J Foxworth

• effects of obesity on functional levels
• effect of nutritional status on fracture healing
• outcomes of spasticity management with botulinum toxin in children with cerebral palsy
• intraoperative navigation for treatment of Blount’s disease
• gait analysis for management of spasticity

Clinical faculty: Emory, Wilson
Basic science faculty:T Smith
Outside collaborators: E Gallagher, A Tallant, J Willey

• inhibition of muscle fibrosis associated with osteosarcoma with angiotensin 1-7
• evaluation of photodynamic bone stabilization systems for pathological fractures

Clinical faculty: Birkedal, O'Gara
Basic science faculty: Danelson

• autograft versus allograft for anterior cervical discectomy and fusion
• outcomes of conservative and surgical management of spine pathology
• postural monitoring to reduce low back pain
• effect of diabetes status and glycemic control as a risk factor in predicting complications following elective spine surgery
• traumatic spinal cord injury: demographics and prevalence
• Warrior Injury Assessment Manikin Project (Department of Defense)