HIRREM Research Publications, Presentations and Media

A key goal of the Wake Forest School of Medicine HIRREM Research Team is to not only apply scientific principles to the evaluation of HIRREM, but also to inform and educate the medical community, and others, about our findings. This is accomplished through publications in peer reviewed journals, presentation of abstracts, as platform or posters at scientific and medical meetings, and oral presentations in other settings such as Grand Rounds, conferences, and the like.

This page reviews such publications and presentations. So as to not compromise the review process of materials not yet published, links are provided only for items which have been published, or officially posted in a public forum.

Publications

Manuscripts

Dagenbach, D.E., Tegeler, C.H., Morgan, A.R., Laurienti, P.J., Tegeler, C.L., Lee, S.W., Gerdes, L. and Simpson, S.L. (2021), Effects of an Allostatic Closed-Loop Neurotechnology (HIRREM) on Brain Functional Connectivity Laterality in Military-Related Traumatic Stress. Journal of Neuroimaging, 31: 287-296. https://doi.org/10.1111/jon.12825.

Tegeler, CL, Shaltout, HA, Lee, SW, Simpson, SL, Gerdes, L, Tegeler, CH. High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) improves symptoms and autonomic function for insomnia: A randomized, placebo-controlled clinical trial. Brain Behav. 2020; 10:e01826. https://doi.org/10.1002/brb3.1826.

Tegeler CL, Shaltout HA, Lee SW, Simpson SL, Gerdes L, Tegeler CH. Pilot Trial of a Noninvasive Closed-Loop Neurotechnology for Stress-Related Symptoms in Law Enforcement: Improvements in Self-Reported Symptoms and Autonomic Function. Global Advances in Health and Medicine. 2020;9. https://doi.org/10.1177/2164956120923288.

Lee, S.W., Laurienti, P.J., Burdette, J.H., Tegeler, C.L., Morgan, A.R., Simpson, S.L., Gerdes, L. and
Tegeler, C.H. (2019), Functional Brain Network Changes Following Use of an Allostatic, ClosedLoop, Acoustic Stimulation Neurotechnology for Military-Related Traumatic Stress. Journal of Neuroimaging, 29: 70-78. https://doi.org/10.1111/jon.12571.

Shaltout H.A., Lee SW, Tegeler CL, Hirsch JR, Simpson SL, Gerdes L, Tegeler CH
(2018). Improvements in heart rate variability, baroreflex sensitivity, and sleep after use of closed-loop allostatic neurotechnology by a heterogeneous cohort. Front Public Health 6:116. https://doi.org/10.3389/fpubh.2018.00116.

Tegeler, C.L., Gerdes, L., Shaltout, H.A. et al. Successful use of closed-loop allostatic neurotechnology for post-traumatic stress symptoms in military personnel: self-reported and autonomic improvements. Military Med Res 4, 38 (2017). https://doi.org/10.1186/s40779-0170147-0.

Tegeler, C.H., Cook, J.F., Tegeler, C.L. et al. Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress. BMC Psychiatry 17, 141 (2017). https://doi.org/10.1186/s12888-017-1299-x.

Tegeler, C.H., Tegeler, C.L., Cook, J.F. et al. A Preliminary Study of the Effectiveness of an Allostatic, Closed-Loop, Acoustic Stimulation Neurotechnology in the Treatment of Athletes with Persisting Post-concussion Symptoms. Sports Med - Open 2, 39 (2016). https://doi.org/10.1186/s40798-016-0063-y.

Fortunato, J.E., Tegeler, C.L., Gerdes, L. et al. Use of an allostatic neurotechnology by adolescents with postural orthostatic tachycardia syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity. Exp Brain Res 234, 791–798 (2016). https://doi.org/10.1007/s00221-015-4499-y.

Gerdes L, Tegeler CH, Lee SW. (2015). A Groundwork for Allostatic Neuro-Education. Front Psychol. 6:1224. https://doi.org/10.3389/fpsyg.2015.01224.

Tegeler, C. H., Shaltout, H. A., Tegeler, C. L., Gerdes, L., Lee, S. W., Rightward dominance in temporal high-frequency electrical asymmetry corresponds to higher resting heart rate and lower baroreflex sensitivity in a heterogeneous population, Brain Behav., 2015; 5(6), e00343, https://doi.org/10.1002/brb3.343.

Tegeler, Charles H. MD1; Tegeler, Catherine L. BS1; Cook, Jared F. MA1; Lee, Sung W. MD, MSc2; Pajewski, Nicholas M. PhD3. Reduction in menopause-related symptoms associated with use of a noninvasive neurotechnology for autocalibration of neural oscillations. Menopause 22(6):p 650-655, June 2015. https://doi.org/10.1097/GME.0000000000000422.

Lee SW, Gerdes L, Tegeler CL, Shaltout HA, Tegeler CH. (2014). A bihemispheric autonomic model for traumatic stress effects on health and behavior. Front. Psychol. 5:843. https://doi.org/10.3389/fpsyg.2014.00843.

Gerdes L, Gerdes P, Lee SW, H Tegeler C. HIRREM™: a noninvasive, allostatic methodology for relaxation and auto-calibration of neural oscillations. Brain Behav. 2013 Mar;3(2):193-205. https://doi.org/10.1002/brb3.116.

Tegeler CH, Kumar S, Conklin D, Lee SW, Gerdes EL, Turner DP, Tegeler CL, Fidali B, Houle TT. (2012). Open label, randomized, crossover pilot trial of high resolution, relational, resonancebased, electroencephalic mirroring (HIRREM) to relieve insomnia. Brain Behav. 2012; 2(6): 814– 824. https://doi.org/10.1002/brb3.101.

Abstracts and Posters

Tegeler, C. L., Howard, L., Brown, K., Asif-Fraz, F., Kellar, D., Shaltout, H. A., & Tegeler, C. H.
(2021, September 27- September 29). Improvement Of Autonomic Function, Sleep, Depression, Anxiety, And Stress In Military Personnel With Traumatic Stress After Use Of A Closed Loop Neurotechnology. Paper presented at the American Heart Association - Hypertension Scientific Sessions 2021, Virtual Event. https://doi.org/10.1161/hyp.78.suppl_1.P206

Shaltout HA, Tegeler CL, Howard L, Brown K, Asif-Fraz F, Kellar D, Tegeler CH. Use Of A Noninvasive, Closed-loop, Allostatic, Neurotechnology Reduced Blood Pressure And Improved Sleep In Heterogeneous Cohort. Paper presented at the American Heart Association - Hypertension Scientific Sessions, 2021, Virtual Event. https://doi.org/10.1161/hyp.78.suppl_1.P205

Shaltout HA, Tegeler CL, Tegeler CH. Use of a Noninvasive, Closed-loop, Allostatic, Neurotechnology Reduced Blood Pressure and Improved Heart Rate Variability in a Prehypertensive Cohort. Abstract P485. Poster presented at the Hypertension 2017 Scientific Sessions, San Francisco, CA, September 14-17, 2017. https://doi.org/10.1161/hyp.70.suppl_1.p485

Tegeler CL, Shaltout HA, Howard LJ, Schmidt KD, Garlin EI, Tegeler CH. Improved Heart Rate Variability, and Symptoms of Insomnia and Stress, With Use of a Closed-loop, Allostatic Neurotechnology in Law Enforcement Officers. Abstract P484. Poster presented at the Hypertension 2017 Scientific Sessions, San Francisco, CA, September 14-17, 2017. https://doi.org/10.1161/hyp.70.suppl_1.p484

Tegeler CH, Tegeler CL, Shaltout HA. Healing a Broken Heart Using a Closed-loop, Allostatic, Neurotechnology: A Case Study in a Patient Suffering From Takotsubo Syndrome. Abstract P483. Poster presented at the Hypertension 2017 Scientific Sessions, San Francisco, CA, September 14-17, 2017. https://doi.org/10.1161/hyp.70.suppl_1.p483

Tegeler CL, Howard LJ, Schmidt KD, Cook JF, Kumar S, Simpson SL, Lee SW, Gerdes L, Tegeler CH. Use of a Closed-Loop Acoustic Stimulation Neurotechnology Improves Symptoms of Moderate to Severe Insomnia: Results of a Placebo-Controlled Trial. Abstract 0389. Poster presented at SLEEP 2017, Boston, MA, June 3-7, 2017. https://doi.org/10.1093/sleepj/zsx050.388

Shaltout HA, Tegeler CL, Lee SW, Tegeler CH. In Subjects with Insomnia, Use of a Closed-Loop Acoustic Stimulation Neurotechnology Improves Heart Rate Variability and Baroreflex Sensitivity: Results of a Placebo-Controlled Clinical Trial. Abstract 0363. Poster presented at SLEEP 2017, Boston, MA, June 3-7, 2017. https://doi.org/10.1093/sleepj/zsx050.362

Nahman J, Dagenbach D, Lyday RG, Laurienti PM, Tegeler CH. Basal ganglia changes in functional connectivity and changes in anxiety. Poster presented at the annual meeting of the North Carolina Cognition Conference, UNC-Greensboro, Greensboro, NC, March 25, 2017.

Shaltout HA, Tegeler CL, Tegeler CH. Reduction of Blood Pressure and Improvement of Heart Rate Variability in Hypertensive Cohort Associated With Use of a Closed Loop Neurotechnology. P310. Poster presented at the Hypertension 2016 Scientific Sessions, Orlando, FL, September 14-17, 2016. https://doi.org/10.1161/hyp.70.suppl_1.p485

Tegeler CL, Shaltout HA, Howard LJ, Tegeler CH. Improved Autonomic Cardiovascular Regulation and Reduced Symptoms Associated with Use of Closed-loop Noninvasive Neurotechnology by Healthcare Workers. P627. Poster presented at the Hypertension 2016 Scientific Sessions, Orlando, FL, September 14-17, 2016. https://doi.org/10.1161/hyp.68.suppl_1.p627

Shaltout HA, Tegeler CL, Tegeler CH. Improvement of Autonomic Function and C-Reactive Protein in Military Personnel with Traumatic Stress After Use Of a Closed Loop Neurotechnology. P625. Poster presented at the Hypertension 2016 Scientific Sessions, Orlando, FL, September 14-17, 2016. https://doi.org/10.1161/hyp.68.suppl_1.p625

Tegeler CL, Shaltout HA, Tegeler CH. Reduced Symptoms And Improved Heart Rate Variability Associated With Use Of Closed-Loop Noninvasive Neurotechnology By Migraineurs. P602. Poster presented at the Hypertension 2016 Scientific Sessions, Orlando, FL, September 14-17, 2016. https://doi.org/10.1161/hyp.68.suppl_1.p602

Tegeler CH, Tegeler CL, Shaltout HA, Cook JF, Simpson SL. Improved symptoms, autonomic cardiovascular regulation, and function after use of a closed-loop neurotechnology for symptoms of military-related traumatic stress. Poster orally presented at the 2016 Military Health System Research Symposium, Orlando/Kissimmee, FL, August 15-18, 2016.

Tegeler CH, Tegeler CL, Morgan AR, Burdette JH, Laurienti PJ. Military personnel with traumatic stress show changes in large-scale brain networks and global perfusion after use of a closedloop neurotechnology. Poster presented at the 2016 Military Health System Research Symposium, Orlando/Kissimmee, FL, August 15-18, 2016.

Lee SW, Gerdes L, Tegeler CH. Sleep Quality as a Modifiable Risk Factor for Primary Prevention of PTSD. Accepted for poster presentation at the 2016 Military Health System Research Symposium, Orlando/Kissimmee, FL, August 15-18, 2016.

Tegeler CL, Howard LJ, Hirsch JR, Shaltout HA, Lee SW, Tegeler CH. Durability of symptom reduction and improved autonomic cardiovascular regulation after use of closed-loop neurotechnology by athletes with persisting post-concussion symptoms. Poster presented at the Sports Concussion Conference, Chicago, IL, July 8-10, 2016.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Shaltout HA, Laurienti PJ. Military personnel with traumatic stress show changes in large-scale brain networks after use of a closed-loop neurotechnology. Neurol. 86(S16): I7.009. Poster presented at dual sessions at the American Academy of Neurology Meeting, Vancouver, BC, Canada, April 15-21, 2016. https://doi.org/10.1212/WNL.86.16_supplement.I7.009

Tegeler CH, Tegeler CL, Cook JF, Howard L, Lee S, Shaltout HA. Durability of symptom reductions associated with use of HIRREM by military personnel with traumatic stress. Neurol. 86(S16): I8.007. Poster presented at dual sessions at the American Academy of Neurology Meeting, Vancouver, BC, Canada, April 15-21, 2016. https://doi.org/10.1212/WNL.86.16_supplement.I8.007

Tegeler CL, Shaltout HA, Lee SW, Tegeler CH. Military personnel with traumatic stress demonstrate improved autonomic cardiovascular regulation after use of a closed loop neurotechnology. Neurol. 86(S16): P5.122. Poster presented at the American Academy of Neurology Meeting, Vancouver, BC, Canada, April 15-21, 2016. https://doi.org/10.1212/WNL.86.16_supplement.P5.122

Tegeler CH, Cook JF, Tegeler CL, Shaltout HA, Laurienti PJ. Military personnel with traumatic stress show improved symptoms and HRV after a closed-loop neurotechnology. Poster presented at the Association of Military Surgeons of the United States Annual Meeting, San Antonio, TX, December 1-4, 2015.

Hirsch JR, Tegeler CL, Cook JF, Lee SW, Shaltout HA, Tegeler CH. Use of HIRREM by Individuals with PTSD is Associated with Reduction of Clinical Symptoms and Increased Heart Rate Variability. Poster presented at Wake Forest School of Medicine for Medical Student Research Day on September 29, 2015.

Tegeler CH, Laurienti PJ, Tegeler CL, Cook JF, Wistermayer PR, Lee SW, Shaltout HA. Military personnel with traumatic stress demonstrate changes in the default mode network after use of a closed-loop neurotechnology. Ann. Neurol. 78(S19): S117WIP. Poster presented at the American Neurological Association Annual Meeting, Chicago, IL, September 27-29, 2015. https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.24498

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Shaltout HA. Use of a closed-loop neurotechnology, HIRREM, is associated with symptom reduction and improved autonomic regulation in migraineurs. Ann. Neurol. 76(S18): S104. Poster presented at the American Neurological Association Annual Meeting, Baltimore, MD, October 12-14, 2014.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Gerdes L, Shaltout HA, Miles CM. Use of HIRREM is associated with improved symptoms and neural oscillatory balance in athletes with postconcussion symptoms. Poster presented at the Sports Concussion Conference, Chicago, IL, July 11-13, 2014.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Franco ME, Nicholas JN, Ray CE, Howard LJ, Shaltout HA. A Noninvasive Approach to Improve Insomnia in a Military Cohort. SLEEP 37 (Abstract Supplement): A192-193. Poster presented at SLEEP 2014 Meeting, Minneapolis, MN, May 31June 3, 2014.

Tegeler CL, Fortunato JE, Cook JF, Lee SW, Franco ME, Tegeler CH. A noninvasive neurotechnology, HIRREM, is associated with symptom reduction and improved cardiovascular autonomic measures in adolescents with POTS. Neurol. 82(S10): P7.320. Poster presented at the 2014 American Academy of Neurology meeting, Philadelphia, PA, April 26-May 3, 2014.

Cook JF, Tegeler CL, Lee SW, Shaltout HA, Franco ME, Tegeler CH. Use of a noninvasive neurotechnology, HIRREM, is associated with improved sleep and mood in a heterogeneous cohort. Neurol. 82(S10): P5.287. Poster presented at the 2014 American Academy of Neurology Meeting, Philadelphia, PA, April 26-May 3, 2014.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Franco ME, Gerdes L, Shaltout HA. Use of a noninvasive neurotechnology, HIRREM, is associated with improved sleep, mood, and baroreflex sensitivity in athletes with persisting post-concussion symptoms. Neurol. 82(S10): P5.313. Poster presented at the 2014 American Academy of Neurology Meeting, Philadelphia, PA, April 26-May 3, 2014.

Miles CM, Tegeler CL, Lee SW, Franco ME, Tegeler CH. A Case (series) of Improved Symmetry. Poster presented at the American Medical Society of Sports Medicine Meeting, New Orleans, LA, April 5-9, 2014.

Lee SW, Tegeler CH, Shaltout H. (2013). Significance of right anterior insula activation for mental health intervention. Letter to the Editor, JAMA Psychiatry 71(3): 336. doi:10.1001/jamapsychiatry.2013.3507. Epub 2014 March.

Tegeler CH, Tegeler CL, Cook JF, Lee SW, Franco ME, Gerdes L, Shaltout HA. Use of HIRREM, a noninvasive neurotechnology, is associated with symptom reduction and increased heart rate variability among individuals with traumatic brain injury. Oral presentation at the 10th World Congress on Brain Injury, San Francisco, CA, March 19-22, 2014.

Fortunato JE, Tegeler CL, Cook JF, Lee SW, Franco ME, Pajewski NM, Shaltout HA, Tegeler CH. (2013). Case series using high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) for POTS. Clin. Autonomic Res. 23(5): 269-70. Presented in poster form at the 24th International Symposium on the Autonomic Nervous System, October 23-26, 2013.

Tegeler CH, Tegeler CL, Lee SW, Cook JF, Shaltout HA. (2013). High-resolution, relational, resonance-based electroencephalic mirroring (HIRREM) reduces symptoms and EEG asymmetry in an individual with PTSD. Ann. Neurol. 74(S17): S77. Presented in poster form at the American Neurological Association Annual Meeting, New Orleans, LA, October 15, 2013.

Tegeler CH, Tegeler CL, Lee SW, Shaltout HA, Pajewski NM. (2013). Neural-oscillatory intervention for auto-calibration reduces EEG asymmetry and increases heart rate variability. Ann. Neurol. 74(S17): S77. Presented in poster form at the American Neurological Association Annual Meeting, New Orleans, LA, October 14-15, 2013.

Tegeler CL, Cook JF, Lee SW, Franco ME, Pajewski NM, Nicholas JN, Tegeler CH. (2013). Pilot study of menopause-related symptom reduction through a noninvasive EEG-based technology for auto-calibration of neural oscillations (HIRREM). Menopause 20(12): 1356. Presented in poster form at the North American Menopause Society Annual Meeting, Dallas, October 9-10, 2013.

Tegeler CH, Tegeler CL, Kumar SR, Turner DP, Gerdes L, Lee SW, Houle TT. (2013). Randomized, placebo-controlled pilot trial of a novel, noninvasive electroencephalic feedback-based intervention, HIRREM, for alleviation of episodic migraine. Cephalalgia 33(S8): 99-100. Presented in poster format International Headache Congress, Boston MA, June 27-30, 2013.

Tegeler CH, Lee SW, Tegeler CL, Shaltout HA. (2013). Correlation between temporal lobe EEG asymmetry and heart rate variability. Neurol. 80 (Meeting abstracts 1): P03:031. Presented in poster form at the American Academy of Neurology Meeting, March 17-22, 2013.

Tegeler CH, Fidali B, Lee SW, Tegeler CL, Gerdes L. Case series of PTSD symptom reduction through a new, noninvasive, EEG-based technology for facilitating self-regulation of neural oscillations (HIRREM). Presented in poster form at 28th Annual Meeting of International Society for Traumatic Stress Studies, Los Angeles CA, November 1-3, 2012.

Tegeler CH, Kumar S, Conklin D, Turner D, Tegeler CL, McCall V, Houle T. (2012). A New Method of Dynamic, Relational, Electroencephalic Auditory Feedback for Primary Insomnia. SLEEP 35 (Abstract Supplement): A220. Presented in poster form at SLEEP 2012, Boston, MA, June 9-13, 2012.

Presentations

Symptoms, Imaging, and Autonomic Outcomes After HIRREM for Symptoms of Military-related Traumatic Stress. Society for Brain Mapping and Therapeutics 2021 Annual Meeting, Los Angeles, CA, March, 2022.

Closed Loop Acoustic Neuromodulation: Noninvasively Engaging the Brain to Balance Itself. MIND Neuroscience Lecture Series, Mechtler Institute for Neurologic Disorders, Budapest, Hungary, March 25, 2022.

Tegeler CH. Update on Symptoms, Imaging, and Autonomic Outcomes After HIRREM for Symptoms of Military-related Traumatic Stress. Society for Brain Mapping and Therapeutics, 19th Annual World Congress, Los Angeles, CA, July 9, 2021 (virtual presentation).

Tegeler CH. Results from a Clinical Trial using HIRREM for Military-Related Traumatic Stress, for the Novel Therapeutics for Combat Related PTSD course, of the Society of Brain Mapping and Therapeutics Annual Meeting, March 20-22, 2020, Los Angeles, CA (meeting postponed due to COVID-19).

Mitigating the Effects of Stress: Practical Tool to Brain Research, WakeOne Clinical Training Department, November 20, 2019, High Point, NC.

Mitigating the Effects of Stress: Practical Tool to Brain Research. Engineering Department, Piedmont Plaza 1, WFBH, October 10, 2019, Winston-Salem, NC.

HIRREM: Results from a study on symptoms of military related traumatic stress. Veteran’s Coffee, PDQ Restaurant, April 18, 2019, Winston-Salem, NC.

Autonomic Management of Traumatic Stress: Engaging the Brain to Balance Itself. Gateway YMCA, April 1, 2019, Winston-Salem, NC.

Symptoms, Imaging, and Autonomic Outcomes After HIRREM for Symptoms of Military-related Traumatic Stress. Society for Brain Mapping and Therapeutics annual meeting, March 15, 2019, Los Angeles, CA.

Autonomic Management of Traumatic Stress: Engaging the Brain to Balance Itself. American Association of Critical Care Nursing, Old Salem Chapter meeting, February 18, 2019, Winston-Salem, NC.

Innovative Approach to Treatment for Persisting Symptoms After TBI. Neuroimaging Update on Concussion, American Society of Neuroimaging 42nd Annual Meeting, January 24, 2019, San Juan Puerto Rico.

Neurotechnology for Insomnia and Stress: The HIRREM Research Program. WFBMC Veteran’s Society meeting, January 18, 2019, Winston-Salem, NC.

HIRREM for Military Post Traumatic Stress. Veteran’s Society, Wake Forest Baptist Medical Center, Winston-Salem, NC, January 18, 2019.

The HIRREM Research Program. Brookview Hills Internal Medicine, Winston-Salem, NC, October 10, 2018.

Autonomic Management of Traumatic Stress: Engaging the Brain to Balance Itself. Brookview Hills Internal Medicine, October 10, 2018, Winston-Salem, NC.

The HIRREM Research Program – Potential for Aging and Caregivers. Memory Counseling Program, Winston-Salem, NC, September 27, 2018.

The HIRREM Research Program. Acute Brain Injury Unit Education on Research Series, WinstonSalem, NC, September 24, 2018.

The Brain, Trauma, and Stress, Acute Brain Injury Unit symposium, September 24, 2018, WFBH, Winston-Salem, NC.

Appreciation, Gratitude, and Art for Health and Well-being, the Women’s Circle. The Health Foundation, Wilkesboro, NC, June 28, 2018.

Using Positive Emotion to Mitigate Effects of Stress. Action Health administrative office team, April 9, 2018, WFSM.

HIRREM: Brainwave Mirroring for Insomnia and Stress. WFSM Dean’s Research Symposia Series, Department of Neurology Symposium, Winston-Salem, NC, March 5, 2018.

Brainwave Mirroring to Reduce Insomnia and Effects of Traumatic Stress: The WFSM HIRREM Research Program. WFSM Alumni Dinner, San Antonio, TX, February 23, 2018.

Use of a closed-loop, allostatic neurotechnology for insomnia: Overview and results of a placebo controlled trial. Department of Physiology and Pharmacology Seminar Series, PTCRC, Winston-Salem, NC, December 13, 2017.

HIRREM for Insomnia: Results of a Placebo Controlled Trial. Department of Neurology Grand Rounds, WFSM, Winston-Salem, NC, October 3, 2017.

Closed-loop Acoustic Stimulation to Reduce Insomnia and Effects of Traumatic Stress: The WFSM HIRREM Research Program. WFSM Medical Alumni Association’s Board of Directors meeting, One Biotech Place, Winston-Salem, NC, May 13, 2017.

Reducing Insomnia and Effects of Traumatic Stress: The HIRREM Research Program. WFSM Medical Alumni Association dinner event, The Dewberry, Charleston, SC, June 22, 2017.

Closed-loop Acoustic Stimulation to Reduce Insomnia and Effects of Traumatic Stress: The
WFSM HIRREM Research Program. Briefing for site visit by faculty from the University of Virginia School of Medicine Contemplative Sciences Center, WFSM, Winston-Salem, NC, March 24, 2017.

Closed-loop Acoustic Stimulation to Reduce Insomnia and Effects of Traumatic Stress: The WFSM HIRREM Research Program. Briefing for Sheriff Bill Schatzman, Forsyth County Sheriff’s Office, and 10 of his leadership team, Winston-Salem, NC, March 17, 2017.

Closed-loop Acoustic Stimulation to Reduce Insomnia and Effects of Traumatic Stress: The
WFSM HIRREM Research Program. Briefing for Chief Barry Rountree, Winston-Salem Police Department, and 15 members of his leadership team, Winston-Salem, NC, March 9, 2017.

Closed-loop Acoustic Stimulation for Auto-calibration of Oscillating Neural Circuits: The WFSM HIRREM Research Program. Briefing/Site Visit by Semper Fi and NICOE, WFSM, February 17th, 2017.

Closed-loop Acoustic Stimulation for Auto-calibration of Oscillating Neural Circuits: The WFSM HIRREM Research Program. Neurology Grand Rounds, UT-Memphis, Memphis, TN, January 27, 2017.

HIRREM Research at WFSM: Overview of Method, Results, and Opportunities. Office of Development and Alumni Affairs, WFSM, November 11, 2016.

Improved symptoms, autonomic cardiovascular regulation, function, and network connectivity after use of a closed-loop, allostatic neurotechnology for symptoms of military-related traumatic stress. Briefing for USASOC leadership team, Fort Bragg, NC, October 19, 2016.

HIRREM Research at Wake Forest School of Medicine (WFSM): Overview and Focus on Military Traumatic Stress, Briefing for Site Visitors from Womack Army Medical Center, and USASOC, at Fort Bragg, NC, August 24, 2016.

Closed-loop Acoustic Stimulation for Auto-calibration of Oscillating Neural Circuits: Overview and Focus on Military Traumatic Stress, Neurology Grand Rounds, University of Texas Health Science Center-San Antonio, San Antonio, TX, July 29, 2016.

HIRREM Research at WFSM: Overview and Focus on Military Traumatic Stress. Briefing for Clinical Research Investigation team at Womack Army Medical Center, Fort Bragg, NC, July 20, 2016.

Durability of Symptom Reductions Associated with Use of HIRREM by Military Personnel with Traumatic Stress, Medical, Biomedical, & Biodefense: Support to the Warfighter Symposium, Raleigh, NC, June 8, 2016.

HIRREM: Overview and Focus on Military Traumatic Stress, Palliative Care Symposium, Body, Mind, & Spirit, Spartanburg Regional Healthcare System, Spartanburg, SC, May 13, 2016.

HIRREM Research at WFSM: Focus on PTSD and Military Traumatic Stress, Sci-Works After Dark, Sci-Works, Winston-Salem, NC, February 23, 2016.

HIRREM Research at WFSM: Focus on Military Traumatic Stress, Department of Family and Community Medicine, Resident Lecture Series, Winston-Salem, NC, February 10, 2016.

HIRREM Research at WFSM: Focus on Military Traumatic Stress, Department of Psychiatry Grand Rounds, Winston-Salem, NC, November 6, 2015.

Balancing the Brain by Feedback with Auditory Tones, Sci-Works Science Café, Clemmons, NC, October 27, 2015.

Overview of HIRREM and Research Program at WFSM, Neuroscience Graduate Students lecture series, Winston-Salem, NC, October 27, 2015.

HIRREM Research Overview, for Hypertension and Vascular Research Center retreat, WinstonSalem, NC, June 22, 2015.

ANS Brain Balance & Dominance: Stress, Depression, & Sleep, for an IGNITE Conference on Autonomic Nervous System and Aging, Sticht Center on Aging, Winston-Salem, NC, March 16, 2015.

Overview of HIRREM and Research Program at WFSM, for Grand Rounds, Center for Health and Healing, Spartanburg Regional Healthcare System, Spartanburg, SC, January 21, 2015.

Overview of HIRREM and Research Program at WFSM, Neuroscience Graduate Students Symposium, November 6, 2014.

Noninvasive Neurotechnology (HIRREM) for Vasomotor Symptoms, for The Science of Thermoregulation and Vasomotor Symptoms: New Targets for Research and Treatment, The 2nd Utian Translational Symposium, Washington, DC, October 14, 2014.

Case Series of HIRREM for Mild TBI, for North Carolina Military Business Center Conference, Raleigh, NC, June 5, 2014.

HIRREM at Wake Forest School of Medicine: Overview and Research Update, for Grand Rounds in the Hypertension and Vascular Research Center at Wake Forest School of Medicine, February 26, 2014.

HIRREM at WFSM: Overview and Potential Military Relevance, for a NC Military Foundation/Marines Special Operations Command briefing, Raleigh, NC, February 24, 2014.

Balance and Neural Oscillations. Key Note Presentation, Healing Without Borders Annual Meeting, Denver, CO, October 5, 2013.

Traumatic Brain Injury/Concussion: A Clinician’s Perspective. MS1 Neuroscience Block, WFSM, April 2, 2013.

HIRREM at WFSM: Update on Clinical Research Outcomes. Office of Women in Medicine and Science Seminar Series, Wake Forest Baptist Health (WFBH), March 6, 2013.

HIRREM at WFSM: Overview and initial Clinical Research. Wake Forest University (WFU) Sports Medicine Staff Conference, WFU, December 4, 2012.

HIRREM at WFSM: Overview and Recent Military Experience. North Carolina (NC) Military Foundation Board of Directors, Chapel Hill, NC, December 3, 2012.

HIRREM at WFSM: Overview and Initial Experience. WFBH Department of Psychiatry Grand Rounds, WFBH, November 16, 2012.

HIRREM at WFSM: Overview for US SOCOM. Special Operations Command, McDill, AFB, October 30, 2012.

HIRREM at WFBH: Overview and Initial Clinical Research. Neuroscience Postgraduate Program Tutorial, WFBH, October 5, 2012.

HIRREM at WFBH: Overview and Initial Clinical Research. Sports Medicine Section meeting, WFBH, September 19, 2012.

HIRREM at WFBH: Program Development and Initial Clinical Research. Kansas University Medical Center, TBI Research Working Group, web presentation, August 30, 2012.

HIRREM at WFBH: Overview and Initial Clinical Research. Center for Integrative Medicine, Spartanburg Regional Medical Center, Spartanburg, SC, August 23, 2012.

BioBiz Partnering Forum, Winston-Salem, NC, June 28, 2012.

HIRREM for Insomnia: Results of a Pilot Clinical Trial. Grand Rounds for Hispanics in Research Capability, University of Puerto Rico, School of Health Professions, San Juan, PR, May 21-22, 2012.

HIRREM for Migraine: Overview and Initial Results of a Pilot Clinical Trial. Action Health, Winston-Salem, NC, March 26, 2012.

HIRREM for Insomnia: Results of a Pilot Clinical Trial. Sticht Center Conference on Aging, WFBH, February 8, 2012.

CIM Update: High-resolution, Relational, Resonance-based, Electroenchephalic Mirroring (HIRREM). CIM Steering Committee Meeting, WFSM, December 12, 2011.

Brainwave Optimization for Insomnia: Results of a Pilot Clinical Trial. Neurology Grand Rounds, WFSM, November 1, 2011.

Symptoms, Imaging, and Autonomic Outcomes after HIRREM for Symptoms of Military-related Traumatic Stress. Society for Brain Mapping and Therapeutics 2021 Annual Meeting, Los Angeles, CA, March, 2022.

Media Coverage

Craver, Richard. “Brain-Imaging Therapy Shows Promise in Treating PTSD Symptoms in Military Personnel.” Winston-Salem Journal, 11 Dec. 2018, https://journalnow.com/news/local/brainimaging-therapy-shows-promise-in-treating-ptsd-symptoms-in/article_a5d92c66-3771-56ae90f0-f58fcde9a6b7.html.

Gerdes, Lee. “Clinical Study Shows CERESET Technology Reduces Symptoms of PTSD in Military Personnel.” EurekAlert!, 21 Nov. 2018, https://www.eurekalert.org/news-releases/828291.

USA Today reported on HIRREM in a special supplement in April 2018.

The US Department of Defense Blast Injury Research Program featured the results of the Military Paper on their homepage in March and April 2018.

O'Connell, Elaina. “How WFBMC Is Making Strides in PTSD Research.” Spectrumlocalnews.com, 6 Feb. 2018, https://spectrumlocalnews.com/nc/triangle-sandhills/news/2018/02/06/howwfbmc-is-making-strides-in-ptsd-research.

Ford, David. “Noninvasive Brainwave Technology Shown to Reduce PTSD Symptoms.” 88.5 WFDD, 31 Jan. 2018, https://www.wfdd.org/story/noninvasive-brainwave-technology-shownreduce-ptsd-symptoms.

Craver, Richard. “Brain Resetting Treatment Shows Promise with Veterans Experiencing PTSD.” Winston-Salem Journal, 29 Jan. 2018, https://journalnow.com/news/local/brain-resettingtreatment-shows-promise-with-veterans-experiencing-ptsd/article_fb6986ee-34df-574b-b4d53d63ea871944.html.

Hero, Project. “Heroes - The Magazine of Project Hero.” AnyFlip, 27 Jan. 2018, http://anyflip.com/adrq/auvo/.

Tegeler CH. Listen up: HIRREM intervention supports PTSD healing. Heroes Magazine (online digital publication), January, 2018:10-12, http://anyflip.com/adrq/auvo/.

Dormehl, Luke. “Sufferers May Be Able to Fight PTSD by Listening to Their Brain Waves.” Digital Trends, Digital Trends, 2 Jan. 2018, https://www.digitaltrends.com/cool-tech/ptsd-brain-wavesmilitary-vet/.

Beck, Margeurite. “Noninvasive Brainwave Technology Improved Post-Traumatic Stress Symptoms in Military Personnel.” Wake Forest Baptist Health, 22 Dec. 2017, https://newsroom.wakehealth.edu/news-releases/2017/12/noninvasive-brainwave-technology-improved-posttraumatic-stress-symptoms-in-military.

An interview with Spectrum News regarding publication of a manuscript reporting use of HIRREM for a case series with symptoms of traumatic stress ran on affiliate television stations across NC, the week of May 8th, 2017.

An article published by The Winston-Salem Journal on October 9, 2016, highlighted results from a published manuscript on athletes with persisting post-concussion symptoms.
Dr. Charles H. Tegeler was interviewed for an article published by Fox News Health on September 29, 2016, about how HIRREM may reduce blood pressure.

An article published on September 16, 2016, by Dennis Thompson of HealthDay, discussed the use of HIRREM to potentially reduce migraine symptoms and blood pressure.

WebMD published an article entitled, “Sound Waves: RX for High Blood Pressure, Migraine? in September 2016.

The America Heart Association issued a press release on September 15, 2016, highlighting two abstracts that were selected for poster presentation at The Council on Hypertension 2016 Scientific Sessions.

Newsweek Magazine published an article on May 9, 2016 entitled, “Rewiring Your Brain: Neurofeedback Goes Mainstream.” https://www.newsweek.com/neurofeedback-brain-regulation-neuroscience-457492

WFDD radio interview HIRREM Research Program at Wake Forest School of Medicine, August 2015.

WSJS Radio interview regarding publication of a research study about a potential new method to assess stress, May 2015.

WXII12 interviewed Dr. Tegeler on May 7, 2015 to discuss a, “New treatment for symptoms of menopause.” https://www.wxii12.com/article/new-treatment-for-symptoms-of-menopause/1896708.

Beck, Margeurite. “Research Study Describes Potential New Method to Assess Stress.” Wake Forest Baptist Health, 4 May 2015,
https://newsroom.wakehealth.edu/news-releases/2015/05/research-study-describes-potential-new-method--to-assess-stress.

Daniel, Fran. “The menopausal transition.” Winston-Salem Journal, 12 Mar. 2015,
https://journalnow.com/the-menopausal-transition/article_2c2cea1a-b340-5777-b5d2-017c0f51836a.html?mode=jqm.

Beck, Margeurite. “Reduction in Menopause-related Symptoms Associated with Non-invasive Neurotechnology.” Wake Forest Baptist Health, 11 Feb. 2015,
https://newsroom.wakehealth.edu/news-releases/2015/02/reduction-in-menopause-related-symptoms-associated-with--noninvasive-neurotechnology.

Beck, Margeurite. “Department of Defense Funds Pilot Study at Wake Forest Baptist to Evaluate Effect of ‘Brainwave Balancing’ on PTSD Symptoms.” Wake Forest Baptist Health, 24 July. 2014, https://newsroom.wakehealth.edu/news-releases/2014/07/department-of-defense-funds-pilot-study-at-wake-forest-baptist.

Craver, Richard. “Grant funds post-concussion brain research.” Winston-Salem Journal, 8 Apr. 2014, https://journalnow.com/news/local/grant-funds-post-concussion-brain-research/article_6a3e1586-e1f9-571a-9d4e-efdbea6bad92.html.

Faria, Paula. “Brainwave ‘Balancing’ Research Receives Continued Support from The Susanne Marcus Collins Foundation.” Wake Forest Baptist Health, 8 Apr. 2014,
https://newsroom.wakehealth.edu/news-releases/2014/04/brainwave-balancing-research-receives-continued-support.

Craver, Richard. “Brainwave study program receives $1 million grant.” Winston-Salem Journal, 30 Jan. 2013, https://journalnow.com/business/business_news/local/article_dd9dd898-6b32-11e2-8677-001a4bcf6878.html.

CBS SF Bay Area interviewed Dr. Tegeler in November 2012 for a story entitled, “HealthWatch: Musical Tones May Help Relieve Insomnia.”

Faria, Paula. “Music to the Ears for a Good Night’s Sleep? Wake Forest Baptist Medical Center Studies New Therapy for Insomnia.” Wake Forest Baptist Health, 19 Nov. 2012,
https://newsroom.wakehealth.edu/news-releases/2012/11/music-to-the-ears-for-a-good-nights-sleep-wake-forest-baptist-studies-new-therapy.

ABC 30 Action News published, “Brain waves beat insomnia” on May 4, 2012. https://abc30.com/archive/8646340/.

Craver, Richard. “$600,000 grant to Wake Forest Baptist will speed research on insomnia, migraines.” Winston-Salem Journal, 27 Feb. 2012, https://journalnow.com/business/article_afa8f45d-b252-53c0-9335-c792294e8c6d.html.

Whittington, Eric. “Grant to Fund Expansion of Brainwave Studies at Wake Forest Baptist.” Wake Forest Baptist Health, 27 Feb. 2012,
https://newsroom.wakehealth.edu/news-releases/2012/02/grant-to-fund-expansion-of-brainwave-studies-at-wake-forest-baptist.

Davis, Bonnie. “Wake Forest Baptist Conducts Clinical Study for Insomnia Using New Technology.” Wake Forest Baptist Health, 30 June. 2011,
https://newsroom.wakehealth.edu/news-releases/2011/06/wake-forest-baptist-conducts-clinical-study-for-insomnia-using-new-technology.

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