Metabolic Phenotyping Shared Resource

The Metabolic Phenotyping Shared Resource (MPSR) provides advanced indirect calorimetry services, technologies and scientific consultation.

We collaborate with researchers to characterize metabolic phenotypes of rodent models with obesity, aging, diabetes, cardiovascular disease, Alzheimer's disease, and cancer.

Publication Highlights

Key CC, Bishop AC, Wang X, Zhao Q, Chen GY, Quinn MA, Zhu X, Zhang Q, Parks JS. Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake. J Lipid Res. 2020 Jul;61(7):1075-1086. doi: 10.1194/jlr.RA120000760. Epub 2020 May 19. PMID: 32430316; PMCID: PMC7328041.

Wang S, Ahmadi S, Nagpal R, Jain S, Mishra SP, Kavanagh K, Zhu X, Wang Z, McClain DA, Kritchevsky SB, Kitzman DW, Yadav H. Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. Geroscience. 2020 Feb;42(1):333-352. doi: 10.1007/s11357-019-00137-4. Epub 2019 Dec 8. PMID: 31814084; PMCID: PMC7031475.

Services Provided

The services provided by core are as follows:

- Consultation and Experimental Design
- Technical Services

* TSE PhenoMaster system is a robust and flexible metabolic screening platform for preclinical research on mice and rats. It offers modularity, high precision and accuracy. The system is an automated metabolic system to study whole-body energy metabolism in live rodents. This system allows multiple animal cages to be simultaneously monitored. Variables provided by this measurement include food, drink, body weight, oxygen consumption, carbon dioxide production, respiratory ratio (the volume of carbon dioxide/oxygen), heat production, total energy expenditure, xyz activity, and running wheels that can be enabled or disabled by time and distance.

* Lipid profile in the blood and tissue

Resource Reservations

Director, Chia-Chi Chuang Key, PhD

Citation Resources

The authors wish to acknowledge the support of the Metabolic Phenotyping Shared Resource supported by Wake Forest CTSI.

Technology Transfer and Commercialization

Research Focus Areas

Translation to Care

More Resources

Publication Highlights

Services Provided

Resource Reservations

Citation Resources

Comprehensive Cancer Center Shared Resources

Bioinformatics

Biostatistics Shared Resource

Cancer Genomics Shared Resource

Cell Engineering Shared Resource

Flow Cytometry Shared Resource

Proteomics and Metabolomics Shared Resource

Qualitative and Patient-Reported Outcomes Shared Resource

Structural Biology and Drug Discovery Shared Resource

Tumor Tissue and Pathology Shared Resource