About Me
My research focuses on the mechanisms and prediction of atrial fibrillation, with an emphasis on the role of circulating biomarkers and imaging markers in disease development. I investigate how metabolic and cardiac biomarkers including ketone bodies, natriuretic peptides, and cardiac troponins, along with imaging markers of subclinical cardiovascular disease, are associated with incident atrial fibrillation and related outcomes. Using large population-based cohorts such as MESA and UK Biobank, my work aims to improve understanding of atrial fibrillation pathophysiology and develop multimodal strategies for earlier risk stratification and prevention.
- Chevli PA, Mirzai S, Kazibwe R, Kingsley J, Wood AC, Yeboah J, Slipczuk L, Mehta A, Bhatia HS, Pandey A, Shapiro MD. Circulating Ketone Bodies and Incident Cardiovascular Outcomes and Mortality: Insights From the UK Biobank. J Am Heart Assoc. 2026 Mar 3;15(5):e042582. doi: 10.1161/JAHA.125.042582. Epub 2026 Feb 20. [PMID: 41717916]
- Kazibwe R, Schaich CL, Chevli PA, Kingsley JA, Mirzai S, Namutebi JH, Imtiaz Ahmad M, Mehta A, Bhatia HS, Paukner M, Rikhi R, Michos ED, Shapiro MD. Lipoprotein(a), Insulin Resistance, and Cardiovascular Disease in the UK Biobank. J Am Heart Assoc. 2026 Feb 17;15(4):e042361. doi: 10.1161/JAHA.125.042361. Epub 2026 Feb 11. [PMID: 41669947]
- Masrouri S, Chevli PA, Bancks MP, Mirzai S, Lima JAC, Bluemke DA, Pagidipati NJ, Shapiro MD. Longitudinal Trajectories of Albuminuria and Risk of Subclinical and Clinical Heart Failure, Atrial Fibrillation, and Coronary Heart Disease: the MESA Study. Eur J Prev Cardiol. 2025 Nov 3:zwaf699. doi: 10.1093/eurjpc/zwaf699. Epub ahead of print. [PMID: 41178268]
- Ahmad MI, Chevli P, Mirzai S, Spitz JA, Sharma G, Lima J, Nasir K, Blaha MJ, Pagidipati NJ, Blumenthal RS, Shapiro MD. Association between cardiovascular- kidney-metabolic syndrome, inflammatory biomarkers, and cardiovascular outcomes: Insights from the MESA study. Atherosclerosis. 2025 Nov;410:120521. doi: 10.1016/j.atherosclerosis.2025.120521. Epub 2025 Oct 2. [PMID: 41066800]
- Ahmad MI, Chevli PA, Mirzai S, Rikhi R, Pagidipati N, Slipczuk L, Szklo M, Shapiro MD. Relationship between interleukin-6, coronary artery calcium and risk of heart failure: Insights from MESA. Am J Prev Cardiol. 2025 Sep 20;24:101310. doi: 10.1016/j.ajpc.2025.101310.; PMCID: PMC12495076. [PMID: 41050552]
- Jain V, Chevli PA, Garg PK, McParland JT, Kizer J, Mukamal K, Schaich CL, Rikhi R, Connelly M, Pandey A, Khan S, Heckbert SR, Shapiro MD. Circulating ketone bodies and risk of incident atrial fibrillation: insights from the MESA and UK Biobank cohorts. Eur J Prev Cardiol. 2025 Sep 24:zwaf543. doi: 10.1093/eurjpc/zwaf543. Epub ahead of print. [PMID: 40991362]
- Kazibwe R, Jehopio J, Schaich CL, Rikhi R, Mirzai S, Chevli PA, Namutebi JH, Chebrolu S, O'Connor S, Yeboah J, Shapiro MD. Atherogenic dyslipidemia and incident cardiovascular events in high-risk hypertension. Prog Cardiovasc Dis. 2025 Sep-Oct;92:121-127. doi: 10.1016/j.pcad.2025.05.006. Epub 2025 May 18. [PMID: 40393568]
- Rikhi R, Haidar A, Bhatia HS, Beam K, McParland J, Kazibwe R, Chevli P, Schaich CL, Sanghavi M, Shapiro MD. Association of lipoprotein(a) and diabetes in primary prevention of coronary heart disease: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2025 May;404:119179. doi: 10.1016/j.atherosclerosis.2025.119179. Epub 2025 Mar 27. [PMID: 40179714]
- Chevli PA, Selvaraj S, Jaeger BC, Hammoud A, Connelly MA, deFilippi C, Lima JAC, Khan SS, Herrington DM, Shapiro MD, Vaduganathan M. Integrating ketone bodies in multi-marker risk prediction of incident heart failure in the multi- ethnic study of atherosclerosis. Eur J Prev Cardiol. 2026 Feb 3;33(2):189-198. doi: 10.1093/eurjpc/zwaf168.; PMCID: PMC12550829. [PMID: 40116814]
- Masrouri S, Tabnak P, Chevli PA, Mirzai S, Slipczuk L, Vasu S, Lima JAC, Shapiro MD. Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study. Eur J Prev Cardiol. 2025 Oct 10;32(14):1296-1309. doi: 10.1093/eurjpc/zwaf163.; PMCID: PMC12510735. [PMID: 40106653]
- Ahmad MI, Chevli PA, Mirzai S, Rikhi R, Bhatia H, Pagidipati N, Blumenthal R, Razavi AC, Ruddiman K, Spitz JA, Nasir K, Shapiro MD. Waist to hip ratio modifies the cardiovascular risk of lipoprotein (a): Insights from MESA. Prog Cardiovasc Dis. 2025 Mar-Apr;89:5-12. doi: 10.1016/j.pcad.2025.03.001. Epub 2025 Mar 11. [PMID: 40081639]
- Chan JSK, Satti DI, Chan RNC, Chevli P, Mehta A, Martin SS, Sharma G, Tse G, Virani SS, Shapiro MD. Visit-to-visit lipid variability, coronary artery calcification, inflammation, and mortality in the Multi-Ethnic Study of Atherosclerosis. Eur J Prev Cardiol. 2025 Sep 22;32(13):1235-1244. doi: 10.1093/eurjpc/zwaf085.; PMCID: PMC12450528. [PMID: 39977247]
- Chevli PA, Razavi AC, Evans JK, Kazibwe R, Connelly MA, Khan SS, Pandey A, Tattersall MC, Stein JH, Shapiro MD. Association between circulating ketone bodies and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA). J Cardiovasc Comput Tomogr. 2025 May-Jun;19(3):358-359. doi: 10.1016/j.jcct.2025.02.001. Epub 2025 Feb 8. [PMID: 39924402]
- Alebna PL, Han CY, Ambrosio M, Kong G, Cyrus JW, Harley K, Kang L, Small AM, Chevli P, Bhatia H, Chew N, Salloum FN, Dixon DL, Abbate A, Natarajan P, Shapiro MD, Mehta A. Association of Lipoprotein(a) With Major Adverse Cardiovascular Events Across hs-CRP: A Systematic Review and Meta-Analysis. JACC Adv. 2024 Nov 19;3(12):101409. doi: 10.1016/j.jacadv.2024.101409.; PMCID: PMC11617504. [PMID: 39640230]
- Chevli PA, Schaich CL, Wood AC, Tk LA, Mehta A, Jain V, Connelly M, Craft S, Shemesh E, Luchsinger JA, Hayden KM, Sachs BC, Hughes TM, Shapiro MD. Association of circulating ketone bodies with cognitive performance and dementia in the Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimers Dement (Amst). 2024 Nov 23;16(4):e70039. doi: 10.1002/dad2.70039.; PMCID: PMC11585168. [PMID: 39583649]
- Kazibwe R, Muhammad AI, Singleton MJ, Evans JK, Chevli PA, Namutebi JH, Kazibwe J, Epiu I, German C, Soliman EZ, Shapiro MD, Yeboah J. Self-rated health and risk of incident cardiovascular events among individuals with hypertension. J Hypertens. 2024 Sep 1;42(9):1573-1580. doi: 10.1097/HJH.0000000000003762. Epub 2024 May 3.; PMCID: PMC11294676. [PMID: 39088765]
- Mirzai S, Chevli PA, Rikhi R, Shapiro MD. Familial Hypercholesterolemia: From Clinical Suspicion to Novel Treatments. Rev Cardiovasc Med. 2023 Nov 9;24(11):311. doi: 10.31083/j.rcm2411311.; PMCID: PMC11272857. [PMID: 39076456]
- Mirzai S, Persits I, Kazibwe R, Gabani M, Seals A, Singleton MJ, Rikhi R, Chevli PA, Carbone S, Tang WHW, Yeboah J, Williamson JD, Kitzman DW, Herrington DM, Shapiro MD. Relationship Between Sarcopenia and Intensive Blood Pressure Control Efficacy and Safety: A Secondary Analysis of SPRINT. Hypertension. 2024 Aug;81(8):e77-e87. doi: 10.1161/HYPERTENSIONAHA.124.23011. Epub 2024 Jun 17.; PMCID: PMC11254568. [PMID: 38881460]
- Kazibwe R, Schaich CL, Muhammad AI, Epiu I, Namutebi JH, Chevli PA, Kazibwe J, Hughes T, Rikhi RR, Shapiro MD, Yeboah J. Effect of vigorous-intensity physical activity on incident cognitive impairment in high-risk hypertension. Alzheimers Dement. 2024 Jul;20(7):4602-4612. doi: 10.1002/alz.13887. Epub 2024 Jun 6.; PMCID: PMC11247677. [PMID: 38842100]
- Scott DA, Ponir C, Shapiro MD, Chevli PA. Associations between insulin resistance indices and subclinical atherosclerosis: A contemporary review. Am J Prev Cardiol. 2024 May 11;18:100676. doi: 10.1016/j.ajpc.2024.100676.; PMCID: PMC11143894. [PMID: 38828124]
- Rikhi R, Schaich CL, Hafzalla GW, Patel NA, Tannenbaum JE, German CA, Polonsky T, Tsai MY, Ahmad MI, Islam T, Chevli PA, Shapiro MD. Small dense low- density lipoprotein cholesterol and coronary artery calcification in the Multi- Ethnic Study of Atherosclerosis. Eur J Prev Cardiol. 2024 Jun 3;31(8):1048-1054. doi: 10.1093/eurjpc/zwae049.; PMCID: PMC11144463. [PMID: 38323698]
- Kazibwe R, Singleton MJ, Ahmad MI, Kaze AD, Chevli PA, Namutebi JH, Kasozi RN, Asiimwe DD, Kazibwe J, Shapiro MD, Yeboah J. Association between weight variability, weight change and clinical outcomes in hypertension. Am J Prev Cardiol. 2023 Oct 20;16:100610. doi: 10.1016/j.ajpc.2023.100610.; PMCID: PMC10630599. [PMID: 37942025]
- Kazibwe R, Chevli PA, Evans JK, Allison M, Michos ED, Wood AC, Ding J, Shapiro MD, Mongraw-Chaffin M. Association Between Alcohol Consumption and Ectopic Fat in the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2023 Sep 19;12(18):e030470. doi: 10.1161/JAHA.123.030470. Epub 2023 Sep 8.; PMCID: PMC10547290. [PMID: 37681576]
- Kazibwe R, Singleton MJ, Chevli PA, Kaze AD, Namutebi JH, Shapiro MD, Yeboah J. Association between physical activity and clinical outcomes in high-risk hypertension: Post-hoc analysis of SPRINT. Am J Prev Cardiol. 2023 Jul 26;16:100524. doi: 10.1016/j.ajpc.2023.100524.; PMCID: PMC10415631. [PMID: 37576387]
- Chong B, Jayabaskaran J, Ruban J, Goh R, Chin YH, Kong G, Ng CH, Lin C, Loong S, Muthiah MD, Khoo CM, Shariff E, Chan MY, Lajeunesse-Trempe F, Tchernof A, Chevli P, Mehta A, Mamas MA, Dimitriadis GK, Chew NWS. Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Circ Cardiovasc Imaging. 2023 May;16(5):e015159. doi: 10.1161/CIRCIMAGING.122.015159. Epub 2023 May 16. [PMID: 37192298]
- Broni EK, Ogunmoroti O, Osibogun O, Echouffo-Tcheugui JB, Chevli PA, Shapiro MD, Ndumele CE, Michos ED. Ideal Cardiovascular Health and Adipokine Levels: The Multi-Ethnic Study of Atherosclerosis. Endocr Pract. 2023 Jun;29(6):456-464. doi: 10.1016/j.eprac.2023.03.276. Epub 2023 Apr 5.; PMCID: PMC10330128. [PMID: 37028649]
- Shemesh E, Chevli PA, Islam T, German CA, Otvos J, Yeboah J, Rodriguez F, deFilippi C, Lima JAC, Blaha M, Pandey A, Vaduganathan M, Shapiro MD. Circulating ketone bodies and cardiovascular outcomes: the MESA study. Eur Heart J. 2023 May 7;44(18):1636-1646. doi: 10.1093/eurheartj/ehad087.; PMCID: PMC10411932. [PMID: 36881667]
- Kiradoh SA, Craven TE, Rangel MO, Nosow LM, Zarrinkhoo E, Menon S, Chevli PA, Islam TM, Thazhatuveetil-Kunhahamed LA. Predicting short-term adverse outcomes in the geriatric population presenting with syncope: a comparison of existing syncope rules and beyond. J Geriatr Cardiol. 2023 Jan 28;20(1):11-22. doi: 10.26599/1671-5411.2023.01.008.; PMCID: PMC9975484. [PMID: 36875169]
- Rikhi R, Bhatia HS, Schaich CL, Ashburn N, Tsai MY, Michos ED, Chevli PA, Herrington DM, Tsimikas S, Shapiro MD. Association of Lp(a) (Lipoprotein[a]) and Hypertension in Primary Prevention of Cardiovascular Disease: The MESA. Hypertension. 2023 Feb;80(2):352-360. doi: 10.1161/HYPERTENSIONAHA.122.20189. Epub 2022 Dec 13.; PMCID: PMC9983733. [PMID: 36511156]
- Al-Seykal I, Bose A, Chevli PA, Hashmath Z, Sharma N, Mishra AK, Laidlaw D. Role of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in cryoballoon ablation outcomes for paroxysmal atrial fibrillation. World J Cardiol. 2022 Oct 26;14(10):537-545. doi: 10.4330/wjc.v14.i10.537.; PMCID: PMC9627355. [PMID: 36339889]
- Rikhi R, Hammoud A, Ashburn N, Snavely AC, Michos ED, Chevli P, Tsai MY, Herrington D, Shapiro MD. Relationship of low-density lipoprotein-cholesterol and lipoprotein(a) to cardiovascular risk: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2022 Dec;363:102-108. doi: 10.1016/j.atherosclerosis.2022.10.004. Epub 2022 Oct 8.; PMCID: PMC9964094. [PMID: 36253168]
- Chevli PA, Islam T, Pokharel Y, Rodriguez F, Virani SS, Blaha MJ, Bertoni AG, Budoff M, Otvos JD, Shapiro MD. Association between remnant lipoprotein cholesterol, high-sensitivity C-reactive protein, and risk of atherosclerotic cardiovascular disease events in the Multi-Ethnic Study of Atherosclerosis (MESA). J Clin Lipidol. 2022 Nov-Dec;16(6):870-877. doi: 10.1016/j.jacl.2022.09.005. Epub 2022 Sep 19. [PMID: 36180367]
- Chevli PA, Mehta A, Allison M, Ding J, Nasir K, Blaha MJ, Blankstein R, Talegawkar SA, Kanaya AM, Shapiro MD, Mongraw-Chaffin M. Relationship of American Heart Association's Life Simple 7, Ectopic Fat, and Insulin Resistance in 5 Racial/Ethnic Groups. J Clin Endocrinol Metab. 2022 May 17;107(6):e2394-e2404. doi: 10.1210/clinem/dgac102.; PMCID: PMC9113808. [PMID: 35188972]
- Chevli PA, Freedman BI, Hsu FC, Xu J, Rudock ME, Ma L, Parks JS, Palmer ND, Shapiro MD. Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study. Cardiovasc Diabetol. 2021 Dec 7;20(1):231. doi: 10.1186/s12933-021-01419-y.; PMCID: PMC8653597. [PMID: 34876126]
- Aladin AI, Chevli PA, Ahmad MI, Rasool SH, Herrington DM. Alcohol Consumption and Systemic Hypertension (from the Third National Health and Nutrition Examination Survey). Am J Cardiol. 2021 Dec 1;160:60-66. doi: 10.1016/j.amjcard.2021.08.033. Epub 2021 Sep 20. [PMID: 34548145]
- Bose A, Hashmath Z, Akella P, Altabaqchali S, Chevli PA, Goyal SB. Idiopathic late coronary sinus lead dislodgement presenting with pulmonary embolism. J Interv Card Electrophysiol. 2021 Nov;62(2):441-442. doi: 10.1007/s10840-021-01024-9. Epub 2021 Jul 2. [PMID: 34212278]
- Bose A, Chevli PA, Berberian G, Januszkiewicz J, Ahmad G, Hashmath Z, Mishra AK, Laidlaw D. Presence of a left common pulmonary vein and pulmonary vein anatomical characteristics as predictors of outcome following cryoballoon ablation for paroxysmal atrial fibrillation. J Interv Card Electrophysiol. 2021 Nov;62(2):409-417. doi: 10.1007/s10840-020-00916-6. Epub 2020 Nov 18. [PMID: 33206281]
- Chevli PA, Hari KJ, Kanaya AM, Talegawkar SA, Needham BL, Herrington D. Association of Alcohol Consumption and Ideal Cardiovascular Health Among South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Alcohol Clin Exp Res. 2020 Sep;44(9):1825-1833. doi: 10.1111/acer.14422. Epub 2020 Aug 20.; PMCID: PMC7722167. [PMID: 32735738]
- Chevli PA, Ahmad MI, Hari K, Anees MA, Soliman EZ. Impact of low fasting plasma glucose on mortality in the general population. Diab Vasc Dis Res. 2020 May-Jun;17(3):1479164120930599. doi: 10.1177/1479164120930599.; PMCID: PMC7607395. [PMID: 32720509]
- Sunkara PR, Islam T, Bose A, Rosenthal GE, Chevli P, Jogu H, Tk LA, Huang CC, Chaudhary D, Beekman D, Dutta A, Menon S, Speiser JL. Impact of structured interdisciplinary bedside rounding on patient outcomes at a large academic health centre. BMJ Qual Saf. 2020 Jul;29(7):569-575. doi: 10.1136/bmjqs-2019-009936. Epub 2019 Dec 6.; PMCID: PMC10189805. [PMID: 31810994]
- Chevli PA, Aladin AI, Kanaya AM, Kandula NR, Malaver D, Herrington DM. Alcohol consumption and subclinical atherosclerosis among South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Nutr Metab Cardiovasc Dis. 2020 Jan 3;30(1):123-131. doi: 10.1016/j.numecd.2019.07.021. Epub 2019 Jul 31.; PMCID: PMC6934907. [PMID: 31753783]
- Jogu HR, Arora S, Vaduganathan M, Qamar A, Pandey A, Chevli PA, Pansuriya TH, Ahmad MI, Dutta A, Sunkara PR, Qureshi W, Vasu S, Upadhya B, Bhatt DL, Januzzi JL Jr, Herrington D. Wake Forest University long-term follow-up of type 2 myocardial infarction: The Wake-Up T2MI Registry. Clin Cardiol. 2019 Jun;42(6):592-604. doi: 10.1002/clc.23182. Epub 2019 Apr 12.; PMCID: PMC6553563. [PMID: 30941774]
- Ahmad MI, Chevli PA, Barot H, Soliman EZ. Interrelationships Between American Heart Association's Life's Simple 7, ECG Silent Myocardial Infarction, and Cardiovascular Mortality. J Am Heart Assoc. 2019 Mar 19;8(6):e011648. doi: 10.1161/JAHA.118.011648.; PMCID: PMC6475074. [PMID: 30859894]
- Chevli PA, Ahmad MI, Jogu HR, Dutta A, Anees MA, Sunkara PR, Aladin AI. Electrocardiographic subclinical myocardial injury and alcohol consumption: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey. Am J Cardiovasc Dis. 2018 Dec 15;8(5):58-65.; PMCID: PMC6334197. [PMID: 30697451]
- Anees MA, Ahmad MI, Chevli PA, Li Y, Soliman EZ. Association of vitamin D deficiency with electrocardiographic markers of left atrial abnormalities. Ann Noninvasive Electrocardiol. 2019 May;24(3):e12626. doi: 10.1111/anec.12626. Epub 2019 Jan 19.; PMCID: PMC6931612. [PMID: 30659705]
- Ahmad MI, Chevli PA, Li Y, Soliman EZ. Vitamin D deficiency and electrocardiographic subclinical myocardial injury: Results from National Health and Nutrition Examination Survey-III. Clin Cardiol. 2018 Nov;41(11):1468-1473. doi: 10.1002/clc.23078. Epub 2018 Nov 20.; PMCID: PMC6489797. [PMID: 30239028]
- Chevli P, Kelash F, Gadhvi P, Grandhi S, Syed A. Spontaneous coronary artery dissection causing acute coronary syndrome in a young patient without risk factors. J Community Hosp Intern Med Perspect. 2014 Sep 29;4(4). doi: 10.3402/jchimp.v4.25104.; PMCID: PMC4185146. [PMID: 25317268]
- Gonzalez-Ibarra F, Chevli P, Schachter L, Kaur M, Eivaz-Mohammadi S, Tashtoush B, Matta J, Syed AK, Marian V. Strongyloidiasis and diffuse alveolar hemorrhage in a patient with systemic lupus erythematosus. Case Rep Med. 2014;2014:278390. doi: 10.1155/2014/278390. Epub 2014 Jun 12.; PMCID: PMC4082940. [PMID: 25024706]