We study mitochondrial metabolism in all number of tissues, cell types, and models. However, our focus is age-related changes in mitochondrial function in the leukocytes and muscle of older adults. In collaboration with other investigators, we have established numerous techniques and protocols to probe the function of these sensitive organelles.
These methods have allowed us to detect systemic declines in mitochondrial function and associate “bioenergetic biomarkers” with pathological processes and other clinical outcomes. With these data, we aim to identify novel targets or therapeutics to improve mitochondrial function and thus modulate disease progression.
These studies also give us new insights into the mechanisms responsible for mitochondrial dysfunction, especially as it relates to oxidative stress and inflammation.
