To advance human health through cutting edge multidisciplinary, collaborative, translational research in nonhuman primates.
- Focus on engagement of translational teams to pursue program-level collaborative research opportunities
- Leverage existing nonhuman primate (NHP) research expertise and resources to advance and expand innovative translational research
- Align with institutional research priorities including Aging, Cancer, Cardiovascular Disease, Diabetes and Obesity, Alzheimer’s Disease, Neurosciences, Substance Misuse Research, Infectious Disease, and Regenerative Medicine
- Provide incentives (pilot funding and project development support) for collaborative, translational engagement by Center members
- Provide leadership and guidance for stewardship of institutional NHP resources
- Facilitate the acquisition of additional high-end equipment and facilities
- Conduct training in basic and translational NHP research
Goal 1: Establish a multi-disciplinary translational NHP Research Center to provide leadership and productive collaboration both intramurally within the Advocate/AWFBH ALHC framework and more broadly with the greater research community.
Goal 2: Engage and support the development of translational multidisciplinary teams to pursue program-level funding opportunities in a goal-oriented manner to address questions of high relevance to our human patient population. To this end, we will:
- Establish focused translational working groups
- Provide pilot funding for novel collaborative research projects
- Support and develop our ongoing training and outreach programs
Goal 3: Optimize stewardship and return on investment for strategic institutional NHP resources including:
- Unique animal populations including the Vervet Research Colony and the Radiation Late Effects Cohort
- Key facilities including the PRIMIR Preclinical Imaging and Irradiation facility and the Clarkson Campus BSL-3 Biocontainment Facility
- Institutional and extramurally-supported NHP biorepositories
- NHP datasets (genomic, imaging, experimental, veterinary clinical, and pathology data)
- Y. Gonzalez-Rodriguez, R. W. Walmer, S. Krainiak, et al., “ Comparison of Laser Doppler Flowmetry With Contrast-Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey (Chlorocebus aethiops sabaeus),” Journal of Medical Primatology 55, no. 1 (2026): e70059, https://doi.org/10.1111/jmp.70059.
https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70059
- Cilvik, S.N.; Sullivan, M.N.; Hobbs, T.R.; Castro, J.N.; Wessel, B.M.; Harrison, H.F.; Roberts, V.H.J. Application of Chorionic Villus Sampling to Longitudinal Studies in Pregnant Non-Human Primate Models. Animals 2026, 16, 374. https://doi.org/10.3390/ani16030374
https://www.mdpi.com/2076-2615/16/3/374?utm_source=researchgate.net&utm_medium=article
- Bhoopal B, Frye BM, Miller M, Bansode A, Gollapelli KK, Barcus RA, Lockhart SN, Damuka N, Sutphen CL, Fitzgerald RW, Kim J, Baxter MG, Jorgensen MJ, Craft S, Register TC, Whitlow CT, Shively CA, Solingapuram Sai KK. PET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys. J Transl Med. 2026 Jan 8;24(1):42. doi: 10.1186/s12967-025-07642-5. PMID: 41501910; PMCID: PMC12784507.
https://pubmed.ncbi.nlm.nih.gov/41501910/
- Huber HF, Ainsworth HC, Quillen EE, Salmon A, Ross C, Azhar AD, Bales K, Basso MA, Coleman K, Colman R, Darusman HS, Hopkins W, Hotchkiss CE, Jorgensen MJ, Kavanagh K, Li C, Mattison JA, Nathanielsz PW, Saputro S, Scorpio DG, Sosa PM, Vallender EJ, Wang Y, Zeiss CJ, Shively CA, Cox LA. Comparative lifespan and healthspan of nonhuman primate species common to biomedical research. Geroscience. 2025 Feb;47(1):135-151. doi: 10.1007/s11357-024-01421-8. Epub 2024 Nov 25. PMID: 39585646; PMCID: PMC11872815.
https://pubmed.ncbi.nlm.nih.gov/39585646/
- Balamayooran G, Tooze JA, Gardin JF, Long MC, Caudell DL, Cline JM, Kock ND, Paitsel M, Moore S, Jorgensen MJ. Age and sex associated organ weight differences in vervets/African green monkeys (Chlorocebus aethiops sabaeus). J Med Primatol. 2024 Aug;53(4):e12721. doi: 10.1111/jmp.12721. PMID: 39048121; PMCID: PMC11378953.
https://pubmed.ncbi.nlm.nih.gov/39048121/
- PMID: 41094312
Age, glucose tolerance, and cognitive performance in female vervet monkeys.
Frye BM, Davis TG, Chen H, Register TC, Craft S, Baxter MG, Shively CA. Geroscience. 2025 Oct 15. doi: 10.1007/s11357-025-01920-2. Online ahead of print. PMID: 41094312
- PMID: 40709334