The primary scientific goals of the Cancer Genetics and Metabolism (CGM) Program are to support the clinical, translational, and basic research missions of the Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) related to two fundamental hallmarks of cancer: genetic alterations and metabolic reprogramming.

There are numerous unmet needs in these areas for extensive research in mechanism, clinical association, and therapeutic opportunities. Recent discoveries have uncovered the intimate interplay between genetics and metabolism in cancer. Alterations in cellular metabolism are emerging as major risk factors for the development and progression of several types of cancer. Importantly, understanding the mechanisms underlying these novel metabolic pathways offers opportunities for targeted therapies.

Specific Aims

Aim 1: To characterize deregulated cancer genome.

Aim 2: To identify novel metabolic vulnerabilities of cancer cells

Aim 3: To leverage the scientific discoveries into novel approaches to the diagnosis and treatment of cancer.

Research Project Highlights