About Me

Mitochondrial dysfunctions and mitochondria-initiated cell death signaling are the primary cause of cell loss associated with the progression of multiple disease conditions. My research focuses on the identification of new molecular regulators and events associated with the mitochondrial (dys)functions and mitochondria-initiated cell death signaling utilizing protein biochemistry, imaging, cellular and molecular tools, and omics-based approaches. I aim to characterize the pathophysiological consequences of these signaling events using mouse genetics and physiology-based in vivo methods.

I received a PhD in Cell Biology and my graduate research was focused on the identification of ubiquitin E3 ligases involved in autophagy and NF-kB signaling. During my postdoctoral training at the Lewis Katz School of Medicine at Temple University, I was intimately involved in decoding the regulatory events of mitochondrial calcium signaling and its crosstalk with other cellular signaling events. We discovered new molecular mechanisms regulating the mitochondrial calcium exchange and mitochondrial calcium uniporter complex and how they contribute to the mitochondrial physiology, calcium-regulated mitochondrial functions, and their involvement in cardiac, hepatic, and neuronal pathophysiology.

Current Projects:

Mitochondrial Ultrastructural Remodeling and Inter-Organelles Crosstalk: I aim to identify the molecular determinants, and signaling events associated with mitochondrial contact sites and mitochondrial membranes architecture.

Protein Quality Control: My research aims to identify the molecular determinants of the mitochondrial protein quality control mechanisms and delineate the associated molecular events that lead to disease onset.

Calcium signaling and mitochondrial ionic homeostasis: I aim to identify the new regulators and regulatory events associated with mitochondrial calcium-sensing/flux and their role in animal physiology using protein biochemistry, high-end imaging-based approaches, and genetic manipulations.

Cardiac Physiology & Metabolism: I aim to characterize the molecular regulators and events involved in cardiac physiology and metabolism using mouse genetics and physiology-based in vivo methods.