Gustavo Antonio Moviglia, MD, PhD

Research Interests

Osteoarthritis

Translational Protocol Development in Cellular Therapy

Relationship Between the Immune System and the Regenerative, Oncogenic and Autoimmune Process, its Importance for Therapy

Spinal Cord Injury

Muscle Atrophy

Fibrosis

About Me

I am an MD, PhD translational researcher. Two intrinsic forces, scientific curiosity and the desire to serve those who suffer from diseases for which no cures currently exist, guided my professional training. Therefore, I studied medicine, and then dedicated my professional activity to the training and study of Cell Biology. Twenty-four years ago, I migrated my professional interests and activity to translational medicine informed by the field of cell therapy.

My knowledge of developmental and cell biology led me to assess the cellular interactions underlying oncogenesis, development of autoimmune diseases and renewal and regeneration of injured tissues using cell-based approaches. Cellular interactions occur, not only through paracrine secretions, but also through contacts and physical communications between damaged cells, those that reach the injured area to repair it (progenitor and immune cells) and the extracellular matrix that helps to direct the course of repair.

This paradigm led me to discover that tissue-specific effector lymphocytes can induce the differentiation of mesenchymal stromal cells into target tissue progenitor cells. Thus, I has translated this scheme of immune directed differentiation of stem cells toward a therapy that allows patients to repair complete, chronic spinal cord injury, and the associated fibro-adipose muscular atrophy. Later I adapted this scheme for regeneration of all the tissues involved in Osteoarthritis and adjunctive therapy on reparative surgery, particularly for lip alveolus palatine cleft and others therapies.

Research

Publications

Clinical Neurorestorative Therapeutic Guidelines for Spinal Cord Injury (IANR/CANR version 2019). Huang H, Young W, Skaper S, Chen L, Moviglia G, Saberi H, Al-Zoubi Z, Sharma HS, Muresanu D, Sharma A, El Masry W, Feng S. . 2020 Jan; 20:14-24.
Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017). Huang H, Young W, Chen L, Feng S, Zoubi ZMA, Sharma HS, Saberi H, Moviglia GA, He X, Muresanu DF, Sharma A, Otom A, Andrews RJ, Al-Zoubi A, Bryukhovetskiy AS, Chernykh ER, Domanska-Janik K, Jafar E, Johnson WE, Li Y, Li D, Luan Z, Mao G, Shetty AK, Siniscalco D, Skaper S, Sun T, Wang Y, Wiklund L, Xue Q, You SW, Zheng Z, Dimitrijevic MR, Masri WSE, Sanberg PR, Xu Q, Luan G, Chopp M, Cho KS, Zhou XF, Wu P, Liu K, Mobasheri H, Ohtori S, Tanaka H, Han F, Feng Y, Zhang S, Lu Y, Zhang Z, Rao Y, Tang Z, Xi H, Wu L, Shen S, Xue M, Xiang G, Guo X, Yang X, Hao Y, Hu Y, Li J, Ao Q, Wang B, Zhang Z, Lu M, Li T. Cell Transplant. 2018 02; 27(2):310-324.
Consensus of clinical neurorestorative progress in patients with complete chronic spinal cord injury. Huang H, Sun T, Chen L, Moviglia G, Chernykh E, von Wild K, Deda H, Kang KS, Kumar A, Jeon SR, Zhang S, Brunelli G, Bohbot A, Soler MD, Li J, Cristante AF, Xi H, Onose G, Kern H, Carraro U, Saberi H, Sharma HS, Sharma A, He X, Muresanu D, Feng S, Otom A, Wang D, Iwatsu K, Lu J, Al-Zoubi A. Cell Transplant. 2014; 23 Suppl 1:S5-17.
In vitro differentiation of adult adipose mesenchymal stem cells into retinal progenitor cells. Moviglia GA, Blasetti N, Zarate JO, Pelayes DE. Ophthalmic Res. 2012; 48 Suppl 1:1-5.
Feasibility, safety, and preliminary proof of principles of autologous neural stem cell treatment combined with T-cell vaccination for ALS patients. Moviglia GA, Moviglia-Brandolino MT, Varela GS, Albanese G, Piccone S, Echegaray G, Martinez G, Blasseti N, Farias J, Farina P, Perusso A, Gaeta CA. Cell Transplant. 2012; 21 Suppl 1:S57-63.

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Research Interests

Fibrosis
Immunotherapy of Cancer
Muscle Atrophy
Osteoarthritis
Relationship Between the Immune System and the Regenerative, Oncogenic and Autoimmune Process, its Importance for Therapy
Spinal Cord Injury
Translational Protocol Development in Cellular Therapy

Technology Transfer and Commercialization

Research Focus Areas

Translation to Care

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Gustavo Antonio Moviglia, MD, PhD

Research Interests

About Me