I have an extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. My research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. These biomaterial systems consist of drug/protein delivery system, nano/micro-scaled topographical feature, and hybrid materials that can actively participate in functional tissue regeneration. Recently, automated 3D bioprinting technology can manufacture complex, multi-cellular living tissue constructs that mimic the structure of native tissues. This can be accomplished by optimizing the formulation of biomaterials to serve as the scaffolding for 3D bioprinting, and by providing the biological environment needed for the successful delivery of cells and biomaterials to discrete locations within the 3D structure.
My research team also demonstrated the principle of “in situ tissue regeneration” that is to take advantage of the body’s own regenerating capacity by using the host's ability to mobilize endogenous stem cells to the site of injury. Currently, our research has focused on development of strategies for in situ tissue regeneration in terms of mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system from the perspective of regenerative medicine and tissue engineering.
Education Program InvolvementBiomedical Engineering PhD
Program Research Interest: Biomaterials, Biomechanics, Biomedical Imaging, Cardiovascular Engineering, Nanomedicine and Nanobioengineering, Neuroengineering, Tissue Engineering, Translational Cancer Research
Molecular Medicine and Translational Science PhD
Program Research Interest: Analytical approaches to molecular and cellular synthesis, structure and function, Genetics and gene regulation, Cell communications, Organ systems, Pathophysiology