About Me

Research Laboratory

Hui Kuan Lin Lab - Providing experience with the mouse genetics in cancer development, molecular biology and cell biology techniques, and transgenic mice techniques and drug development.

Educational Program Involvement

Cancer Biology PhD
Program Research Interest: Cellular defense and metabolism, Aberrant signaling pathways in tumor cells, Cell growth and survival, Molecular cancer epidemiology, Gene-environment interactions, Cancer control

Research

Publications

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, Wu SY, Yang SC, Hsu FC, D'Agostino RB, Furdui CM, Kucera GL, Parks JS, Chilton FH, Huang CY, Tsai FJ, Pasche B, Watabe K, Lin HK. Mol Cell. 2020 10; 80(2):263-278.e7.
Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, Peng D, Xu X, Lin HK. Cell Discov. 2020; 6:15.
The Skp2 Pathway: A Critical Target for Cancer Therapy. Cai Z, Moten A, Peng D, Hsu CC, Pan BS, Manne R, Li HY, Lin HK. Semin Cancer Biol. 2020 12; 67(Pt 2):16-33.
Cell. 2019 Jun 27;178(1):176-189.e15. doi: 10.1016/j.cell.2019.05.003. Epub 2019 May 30. Zhang W, Wang G, Xu ZG, Tu H, Hu F, Dai J, Chang Y, Chen Y, Lu Y, Zeng H, Cai Z, Han F, Xu C, Jin G, Sun L, Pan BS, Lai SW, Hsu CC, Xu J, Chen ZZ, Li HY, Seth P, Hu J, Zhang X, Li H, Lin HK. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. 2019 Jun; 27;
Nat Cell Biol. 2019 Feb;21(2):214-225. doi: 10.1038/s41556-018-0266-1. Epub 2019 Jan 28. Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, Sun L, Yang SC, Lan J, Hou Z, Cai Z, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. 2019 Feb; 21;

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Research Interests

Aging
Cancer Cell Signaling
Cancer Immunotherapy
Cancer Stem Cells
Disease Models, Animal
DNA Repair
Drug Development
Immunity, Innate
Metabolism
Ubiquitin-Protein Ligases

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Research Focus Areas

Translation to Care

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Hui-Kuan Lin, PhD

Hui-Kuan Lin, PhD

Research Interests

About Me

Research Laboratory

Educational Program Involvement