Wake Forest Translational Alcohol Research Center Publications

December 2017 – November 2018

1. Melchior JR, Jones SR. Chronic ethanol exposure increases inhibition of optically targeted
phasic dopamine release in the nucleus accumbens core and medial shell ex vivo. Molecular
and cellular neurosciences. 2017;85:93-104. PubMed PMID: 28942046; PubMed Central
PMCID: PMC5698100; DOI: 10.1016/j.mcn.2017.09.007

2. Karkhanis A, Holleran, KM, Jones SR. Dynorphin/Kappa opioid receptor signaling in
preclinical models of alcohol, drug, and food addiction. International Review of
Neurobiology. 2017;136:53-88. PMID: 29056156; DOI: 10.1016/bs.irn.2017.08.001

3. Mayhugh RE, Laurienti PJ, Fanning J, Gauvin L, Heilman KJ, Porges SW, Rejeski WJ.
Cardiac vagal dysfunction moderates patterns of craving across the day in moderate to
heavy consumers of alcohol. PloS one. 2018;13(7):e0200424. PubMed PMID: 30016350;
PubMed Central PMCID: PMC6049906; DOI: 10.1371/journal.pone.0200424.

4. Deal AL, Konstantopoulos JK, Weiner JL, Budygin EA. Exploring the consequences of social
defeat stress and intermittent ethanol drinking on dopamine dynamics in the rat nucleus
accumbens. Scientific reports. 2018;8(1):332. PubMed PMID: 29321525; PubMed Central
PMCID: PMC5762836; DOI: 10.1038/s41598-017-18706-y

5. Siciliano CA, Karkhanis AN, Holleran KM, Melchior JR, Jones SR. Cross-species alterations
in synaptic dopamine regulation after chronic alcohol exposure. Handb Exp
Pharmacol. 2018; 248:213-238. PMID: 29675581; PMCID: PMC6195853;
DOI: 10.1007/164_2018_106.

6. Mauterer MI, Estave PM, Holleran KM, Jones SR. Measuring dopamine using fast-scan
cyclic voltammetry in rodent brain slices. Bio Protoc. 2018; 8(19):e2473. PMID: 3453250;
PMCID: PMC8342126; DOI: 10.21769/BioProtoc.2473

7. Mayhugh RE, Rejeski WJ, Petrie MR, Laurienti PJ, Gauvin L. Differing patterns of stress and
craving across the day in moderate-heavy alcohol consumers during their typical drinking
routine and an imposed period of alcohol abstinence. PLoS One. 2018;13(4):e0195063. doi:
10.1371/journal.pone.0195063. PMID: 29668736; PMCID: PMC5906009.

8. Montague PR, Kishida KT. Computational Underpinnings of Neuromodulation in Humans.
Cold Spring Harbor Symposia on Quantitative Biology. 2018;83:71-82. doi:

9. Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR, Tatter SB, Ellis TL,
Phillips PE, Dayan P, Montague PR. The Protective Action Encoding of Serotonin Transients
in the Human Brain. Neuropsychopharmacology. 2018;43(6):1425-1435. doi:

10. Alexander NJ, Rau AR, Jimenez VA, Daunais JB, Grant KA, McCool BA. SNARE complexassociated proteins in the lateral amygdala of macaca mulatta following long-term ethanol drinking. Alcoholism: Clinical and Experimental Research. 2018;42(9):1661-1673. PubMed PMID: 29944190; PubMed Central PMCID: PMC6120765; DOI: 10.1111/acer.13821.

11. McGuier NS, Rinker JA, Cannady R, Fulmer DB, Jones SR, Hoffman M, Mulholland PJ.
Identification and validation of midbrain Kcnq4 regulation of heavy alcohol consumption in
rodents. Neuropharmacology. 2018;138:10-19. PubMed PMID: 29775679; PubMed Central
PMCID: PMC6054890; DOI: 10.1016/j.neuropharm.2018.05.020.

December 2018 – November 2019

12. Thomas SG, Czoty PW. Effect of menstrual cycle on ethanol drinking in rhesus monkeys.
Drug and alcohol dependence. 2019;194:205-209. PubMed PMID: 30453105; PubMed
Central PMCID: PMC6312462; DOI: 10.1016/j.drugalcdep.2018.11.001.

13. Ewin SE, Morgan JW, Niere F, McMullen NP, Barth SH, Almonte AG, Raab-Graham KF,
Weiner JL. Chronic Intermittent Ethanol Exposure Selectively Increases Synaptic Excitability
in the Ventral Domain of the Rat Hippocampus. Neuroscience. 2019;398:144-157. PubMed
PMID: 30481568; PubMed Central PMCID: PMC6658135; DOI:

14. Wolfe SA, Farris SP, Mayfield JE, Heaney CF, Erickson EK, Harris RA, Mayfield RD, Raab-
Graham KF. Ethanol and a rapid-acting antidepressant produce overlapping changes in exon
expression in the synaptic transcriptome. Neuropharmacology. 2019;146:289-299. PubMed
PMID: 30419244; PubMed Central PMCID: PMC6778957; DOI:

15. Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL,
McCool BA, Raab-Graham KF, Ferris MJ, Jones SR. Chronic Social Isolation Stress during
Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in
Accumbal Dopamine Availability. ACS chemical neuroscience. 2019;10(4):2033-2044.
PubMed PMID: 30284806; PubMed Central PMCID: PMC6467761; DOI:

16. Schmidt KT, Makhijani VH, Boyt KM, Cogan ES, Pati D, Pina MM, Bravo IM, Locke JL, Jones SR, Besheer J, McElligott ZA. Stress-Induced Alterations of Norepinephrine Release in the Bed Nucleus of the Stria Terminalis of Mice. ACS chemical neuroscience. 2019;10(4):1908-
1914. PubMed PMID: 30252438; PubMed Central PMCID: PMC6500727; DOI:

17. Flynn SM, Epperly PM, Davenport AT, Cami-Kobeci G, Husbands SM, Ko MC, Czoty PW.
Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on
alcohol drinking in rhesus monkeys. Neuropsychopharmacology 2019;44(8):1476-1484.
PubMed PMID: 30970376; PubMed Central PMCID: PMC6784996; DOI: 10.1038/s41386-

18. Frost ME, Peterson VL, Bird CW, McCool B, Hamilton DA. Effects of ethanol exposure and
withdrawal on neuronal morphology in the agranular insular and prelimbic cortices:
relationship with withdrawal-related structural plasticity in the nucleus accumbens. Brain
Sciences. 2019;9(8). PubMed PMID: 31357611; PubMed Central PMCID: PMC6721441;
DOI: 10.3390/brainsci9080180.

19. Rice J, Coutellier L, Weiner JL, Gu C. Region-specific interneuron demylelination and
heightened anxiety-like behavior induced by adolescent binge alcohol treatment. Acta
Neuropathologica Communications. 2019;7(1):173. doi: 10.1186/s40478-019-0829-9.

20. Deal AL, Mikhailova MA, Grinevich VP, Weiner JL, Gainetdinov RR, Budygin EA. In vivo
voltammetric evidence that locus coeruleus activation predominantly releases norepinephrine
in the infralimbic cortex: effect of acute ethanol. Synapse. 2019;73(4):e22080. doi:

December 2019 – November 2020

21. Bahrami M, Lyday RG, Casanova R, Burdette JH, Simpson SL, Laurienti PJ. Using lowdimensional
manifolds to map relationships between dynamic brain networks. Frontiers in
human neuroscience. 2019;13:430. PubMed PMID: 31920590; PubMed Central PMCID:
PMC6914694; DOI: 10.3389/fnhum.2019.00430.

22. Peterson H, Simpson SL, Laurienti PJ. Wake Forest Alcohol Imagery Set: development and
validation of a large standardized alcohol imagery dataset. Alcoholism: Clinical and
Experimental Research. 2019; 43(12):2559-2567. PubMed PMID: 31595975; PubMed
Central PMCID: PMC6904540; DOI: 10.1111/acer.14214.

23. Bahrami M, Laurienti PJ, Simpson SL. Analysis of brain subnetworks within the context of
their whole-brain networks. Human Brain Mapping. 2019;40(17):5123-5141. doi:
10.1002/hbm.24762. PMID: 31441167; PMCID: PMC6865778.

24. Godfrey JR, Pincus M, Kovacs-Balint Z, Feczko E, Earl E, Miranda-Dominguez O, Fair
DA, Jones SR, Locke J, Sanchez MM, Wilson ME, Michopoulos V. Obesogenic dietassociated
C-reactive protein predicts reduced central dopamine and corticostriatal functional
connectivity in female rhesus monkeys. Brain, Behavior, and Immunity. 2020; 88:166-173.
PMID: 32240763; PMCID: PMC7416544; DOI: 10.1016/j.bbi.2020.03.030.

25. McGinnis MM, Parrish BC, Chappell AM, Alexander NJ, McCool BA. Chronic ethanol
differentially modulates glutamate release from dorsal and ventral prefrontal cortical inputs
onto rat basolateral amygdala principal neurons. eNeuro. 2020;7(2):ENEURO.0132-19.2019.
doi: 10.1523/ENEURO.0132-19.2019.

26. Pitts EG, Stowe TA, Christensen BA, Ferris MJ. Comparing dopamine release, uptake, and
D2 autoreceptor function across the ventromedial to dorsolateral striatum in adolescent and
adult male and female rats. Neuropharmacology. 2020;175:108163. PubMed PMID:
32479812; DOI: 10.1016/j.neuropharm.2020.108163.

27. McGinnis MM, Parrish BC, McCool BA. Withdrawal from chronic ethanol exposure increases
postsynaptic glutamate function of insular cortex projections to the rat basolateral amygdala.
Neuropharmacology. 2020;172:108129. PubMed PMID: 32418906; PubMed Central PMCID:
PMC7313316; DOI: 10.1016/j.neuropharm.2020.108129.

28. Deal AL, Bass CE, Grinevich VP, Delbono O, Bonin KD, Weiner JL, Budygin EA.
Bidirectional control of alcohol-drinking behaviors through locus coeruleus optoactivation.
Neuroscience. 2020;443:84-92. doi: 10.1016/j.neuroscience.2020.07.024. Epub 2020 Jul 21.

29. Budygin EA, Bass CE, Grinevich VP, Deal AL, Bonin KD, Weiner JL. Opposite consequence
of tonic and phasic increases in accumbal dopamine on alcohol-seeking behavior. iScience.
2020;23(3):100877. doi: 10.1016/j.isci.2020.100877. Epub 2020 Jan 31.

30. Damuka N, Czoty PW, Davis AT, Nader MA, Nader SH, Craft S, Macauley SL, Galbo LK,
Epperly PM, Whitlow CT, Davenport AT, Martin TJ, Daunais JB, Mintz A, Sai KKS. PET
imaging of [11C]MPC-6827, a microtubule-based radiotracer in non-human primate brains.
Molecules. 2020;25(10):2289. doi: 10.3390/molecules25102289.

December 2020 – November 2021

31. Holleran KM, Rose JH, Fordahl SC, Benton KC, Rohr KE, Gasser PJ, Jones SR. Organic
cation transporter 3 and the dopamine transporter differentially regulate catecholamine
uptake in the basolateral amygdala and nucleus accumbens. European Journal of
Neuroscience. 2020; 52(11):4546-4562. PMID: 32725894;
PMCID: PMC7775350; DOI: 10.1111/ejn.14927.

32. Bang D, Kishida KT, Lohrenz T, White JP, Laxton AW, Tatter SB, Fleming SM, Montague
PR. Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual
Decision-Making. Neuron. 2020;108(5):999-1010.e6. doi: 10.1016/j.neuron.2020.09.015

33. Bach EC, Weiner JL. Binge-like alcohol drinking remodels the inhibitory microcircuitry of the
prelimbic cortex in male and female mice. Neuropsychopharmacology 2021;46(11):1859-
1860. doi: 10.1038/s41386-021-01103-5.

34. Bach EC, Morgan JW, Ewin SE, Barth SH, Raab-Graham KF, Weiner JL. Chronic ethanol
exposure leads to a negative affective state in female rats that is accompanied by a
paradoxical decrease in ventral hippocampus excitability. Frontiers in Neuroscience.
2021;15:669075. doi: 10.3389/fnins.2021.669075.

35. Deal AL, Park J, Weiner JL, Budygin EA. Stress alters the effect of alcohol on catecholamine dynamics in the basolateral amygdala. Frontiers in Behavioral Neuroscience.
2021;15:640651. doi: 10.3389/fnbeh.2021.640651

36. Bach EC, Ewin SE, Baldassaro AD, Carlon HN, Weiner JL. Chronic intermittent ethanol
promotes ventral subiculum hyperexcitability via increases in intrinsic basolateral amygdala
input and local network activity. Scientific Reports. 2021;11(1):8749. doi: 10.1038/s41598-

37. Damuka N, Orr M, Czoty PW, Weiner JL, Martin TJ, Nader MA, Bansode AH, Liyana
Pathirannahel BS, Mintz A, Macauley SL, Craft S, Solingapuram Sai KK. Effect of ethanol
and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells. Molecular Biology Reports.
2021;48(4):3871-3876. doi: 10.1007/s11033-021-06336-7.

38. George BE, Barth SH, Kuiper LB, Holleran KM, Lacy RT, Raab-Graham KF, Jones SR.
Enhanced heroin self-administration and distinct dopamine adaptations in female rats.
Neuropsychopharmacology. 2021; 46(10):1724-1733. PMID: 3404015;
PMCID: PMC8358024; DOI: 10.1038/s41386-021-01035-0

39. Brundage JN, Mason CP , Wadsworth HA, Finuf CS, Nelson JJ, Ronström PJW, Jones
SR, Siciliano CA, Steffensen SC, Yorgason JT. Regional and sex differences in
spontaneous striatal dopamine transmission. Journal of Neurochemistry. 2021;46(10):1724-
1733. PMID: 3426508 DOI: 10.1111/jnc.15473

40. Jones SR, Fordhal SC. Bingeing on High-Fat Food Enhances Evoked Dopamine Release
and Reduces Dopamine Uptake in the Nucleus Accumbens. Obesity. 2021;29(4):721-730.
PMID: 33660412; PMCID: PMC8048651; DOI: 10.1002/oby.23122

41. Heaney CF, Namjoshi SV, Uneri A, Bach EC, Weiner JL, Raab-Graham KF. Role of FMRP in rapid antidepressant effects and synapse regulation. Molecular Psychiatry. 2021;26(6):2350-
2362. doi: 10.1038/s41380-020-00977-z.

42. Carlson HN, Weiner JL. The neural, behavioral, and epidemiological underpinnings of
comorbid alcohol use disorder and post-traumatic stress disorder. International Review of
Neurobiology. 2021;157:69-142. doi: 10.1016/bs.irn.2020.09.006.

43. Deal A, Cooper N, Kirse HA, Uneri A, Raab-Graham K, Weiner JL, Solberg-Woods LC. Early life stress induces hyperactivity but not increased anxiety-like behavior or ethanol drinking in outbred heterogeneous stock rats. Alcohol. 2021;91:41-51.

44. Hanlon CA, Czoty PW, Smith HR, Epperly PM, Galbo LK. Cortical excitability in a nonhuman
primate model of TMS. Brain Stimulation. 2021;14(1):19-21. doi: 10.1016/j.brs.2020.10.008.

45. Sizer SE, Parrish BC, McCool BA. Chronic ethanol exposure potentiates cholinergic
neurotransmission in the basolateral amygdala. Neuroscience. 2021;455:165-176. doi:

46. McCool BA. Ethanol modulation of cortico-basolateral amygdala circuits: neurophysiology
and behavior. Neuropharmacology. 2021;197:108750.

47. Alberto GE, Stapleton-Kotloski JR, Klorig DC, Rogers ER, Constantinidis C, Daunais
JB, Godwin DW. MEG source imaging detects optogenetically-induced activity in cortical and
subcortical networks. Nature Communications. 2021;12(1):5259. doi: 10.1038/s41467-021-

48. Rowland JA, Stapleton-Kotloski JR, Alberto GE, Davenport AT, Epperly PM, Godwin DW,
Daunais JB. Rich club characteristics of alcohol-naïve functional brain networks predict future
drinking phenotypes in rhesus macaques. Frontiers in Behavioral Neuroscience.
2021;15:673151. doi: 10.3389/fnbeh.2021.673151.

49. Peterson H, Mayhugh RE, Bahrami M, Rejeski WJ, Simpson SL, Heilman K, Porges
SW, Laurienti PJ. Influence of heart rate variability on abstinence-related changes in brain
state in everyday drinkers. Brain Sciences. 2021;11(6):817. doi: 10.3390/brainsci11060817.

50. Tessa L. Steel , Majid Afshar , Scott Edwards , Sarah E. Jolley , Christine Timko , Brendan J. Clark , Ivor S. Douglas , Amy L. Dzierba , Hayley B. Gershengorn , Nicholas W.
Gilpin , Dwayne W. Godwin , Catherine L. Hough , José R. Maldonado , Anuj B.
Mehta , Lewis S. Nelson , Mayur B. Patel , Darius A. Rastegar , Joanna L. Stollings , Boris
Tabakoff , Judith A. Tate , Adrian Wong , and Ellen L. Burnham. Research needs for inpatient
management of severe alcohol withdrawal syndrome: an official American Thoracic Society
research statement. American Journal of Respiratory and Critical Care Medicine. 2021;204:
e61-67. doi: 10.1164/rccm.202108-1845ST.

51. Galbo LK, Davenport AT, Epperly PM, Daunais JB, Stinson BT, Czoty, PW. Social
dominance in monkeys: lack of effect on ethanol self-administration during schedule
induction. Alcohol. 2021; doi: 10.1016/j.alcohol.2021.10.001. in press.

52. Price ME, McCool MA. Structural, functional, and behavioral significance of sex and gonadal hormones in the basolateral amygdala: A review of preclinical literature. Alcohol. 2022; 98: 25-41. DOI: 10.1016/j.alcohol.2021.08.001

December 2021 – November 2022

53. Price ME, McCool BA. Chronic ethanol dysregulates glutamatergic function in basolateral amygdala in a projection- and sex-specific manner. Frontiers in Cellular Neuroscience. 2022 doi: 10.3389/fncel.2022.857550. in press