My research interest is aimed at comprehensive understanding of biological mechanisms underlying imaging and treatment outcomes and focuses on development of:
- drug delivery system to facilitate brain cancer-targeted molecular imaging diagnosis and imaging-guided drug delivery
- novel nanoparticle-immunotherapy system to elicit anticancer immunity
We recently developed a brain cancer-targeted nanoplatform that enables delivery of anti-cancer therapeutic agents or imaging contrast agents to brain tumor parenchyma but not to normal brain. Using this nanoplatform, we have demonstrated sensitive and specific detection of brain cancer with bimodal MRI/optical imaging and MRI-guided delivery of anti-cancer agents to treat glioma. Also, my laboratory has developed a novel nano-immunotherapeutic system to enhance anti-cancer immunity against lung cancer.
- In vivo imaging of the brain tumor microenvironment – We are applying multimodal MRI/optical imaging to interrogate brain tumor microenvironment, in particular, the blood brain barrier (BBB).
- Imaging-guided delivery of brain tumor-targeted nano-drugs – We are developing brain tumor-targeted nanohybrid of imaging contrast agents and anti-cancer therapeutic agents in this NIH R01 project.
- Novel nanoparticle-immunotherapy system to elicit anticancer immunity – We are exploring a novel nanoparticle-immunotherapy system developed at my lab, aiming to enhance anti-cancer immunity.
Zhao Lab – Integrated cancer biology, imaging and experimental therapeutics to enhance comprehensive understanding and interpretation of imaging and treatment outcomes.
Education Program Involvement
Biomedical Engineering PhD
Program Research Interest: Biomaterials, Biomechanics, Biomedical Imaging, Cardiovascular Engineering, Nanomedicine and Nanobioengineering, Neuroengineering, Tissue Engineering, Translational Cancer Research
Cancer Biology PhD
Program Research Interest: Cellular defense and metabolism, Aberrant signaling pathways in tumor cells, Cell growth and survival, Molecular cancer epidemiology, Gene-environment interactions, Cancer control