The Shiozawa Lab is focusing on identifying the mechanisms of cancer bone metastasis and its painful complications. We investigate the cross-communication between bone metastatic cancer cells and sensory nerves in the bone to help develop novel treatment strategies to lower cancer-associated deaths and to improve the quality of life of cancer patients with bone metastases. Our research is funded by grants from the Department of Defense.
We also investigate cancer-associated muscle wasting, which complicates treatment plans since chemotherapies are often too toxic and major surgeries are too high-risk for cancer patients with muscle wasting. Understanding the mechanisms involved can result in significant improvements in patients' quality of life and in the care of advanced cancer patients by avoiding unnecessary suspension or discontinuation of life-saving treatments.