I am a biomedical engineer studying the dynamic physiologic response to traumatic injuries, with a particular focus on hemorrhagic shock and traumatic brain injury (TBI). Our primary interest is in understanding key biological events following major hemorrhage and/or TBI where we can potentially intervene and help improve patient outcomes. Our lab has experience in performing a wide range of bench-top, animal and human clinical studies. We develop novel approaches and experimental methods to improve the efficacy of blood transfusions, identify new biomarkers that can provide meaningful clinical decision support, and use engineering and computational approaches to investigate the relationship between hemodynamics and molecular biology after trauma. Most recently, we have expanded our studies to include patient specific (or precision) based biomarkers, such as genomic, metabolomic and lipidomic markers, for the improved management and treatment of trauma. The overall goal of our lab is to discover new treatments for major bleeding and TBI.
- Investigating FADS gene-diet interactions in critically injured patients - We are determining how FADS genetic variants impact an individual’s response to immune-modulatory diets and their overall inflammatory status following injury.
- Development of computational fluid models for hemorrhagic shock - We are exploring computational fluid modeling approaches to studying hemorrhagic shock and treatment using endovascular control devices, in collaboration with Dr. Timothy Williams.
- Traumatic Brain Injury - In collaboration with Aleks Skardal, we are developing a 3D tissue engineered blood brain barrier model complete with a vascular compartment to study TBI.
Education Program InvolvementBiomedical Engineering PhD Program Research Interest: Biomaterials, Biomechanics, Biomedical Imaging, Cardiovascular Engineering, Nanomedicine and Nanobioengineering, Neuroengineering, Tissue Engineering, Translational Cancer Research
Integrative Physiology and Pharmacology PhD
Program Research Interest: Drug and Alcohol Abuse, Cardiovascular Physiology and Hypertension, Regenerative Medicine, Neuro- and Behavioral Pharmacology, Cancer Therapeutics Endocrinology, Diabetes, and Metabolism Lifespan Physiology.