John S. Parks, PhD

Professor, Molecular Medicine

Research Interests

Cholesterol, HDL
Fatty Liver
Lipid Metabolism
Molecular Medicine

About Me

I am a basic scientist interested lipid metabolism in pre-clinical models of chronic diseases, such atherosclerosis, fatty liver disease and obesity/type 2 diabetes.

Education Program Involvement

Molecular Medicine and Translational Science PhD
Program Research Interest: Analytical approaches to molecular and cellular synthesis, structure and function, Genetics and gene regulation, Cell communications, Organ systems, Pathophysiology

Education: BS, North Carolina State University, 1973; MS, Wake Forest University, 1976; PhD, Wake Forest University, 1979
Fellowship: Biophysical Chemistry, Boston University School of Medicine, 1981
Memberships: AHA - Council on Arteriosclerosis
Positions: Section Chief, Molecular Medicine; Professor, Molecular Medicine; Professor, Biochemistry
Departments and Affiliations: Molecular Medicine; Biochemistry; Sticht Center for Healthy Aging and Alzheimer’s Prevention; Center for Redox Biology and Medicine; Center on Diabetes, Obesity, and Metabolism; Center for Precision Medicine; Comprehensive Cancer Center; Cardiovascular Sciences Center

Research

Publications

Multi-omics Analyses Identify AKR1A1 as a Biomarker for Diabetic Kidney Disease. Li D, Hsu FC, Palmer ND, Liu L, Choi YA, Murea M, Parks JS, Bowden DW, Freedman BI, Ma L. Diabetes. 2024 Feb;
Hepatocyte ABCA1 deficiency is associated with reduced HDL sphingolipids. Othman A, Liu M, Bode H, Boudyguina E, von Eckardstein A, Parks JS, Hornemann T. Front Physiol. 2023; 14:1208719.
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury. Guo Z, Valenzuela Ripoll C, Picataggi A, Rawnsley DR, Ozcan M, Chirinos JA, Chendamarai E, Girardi A, Riehl T, Evie H, Diab A, Kovacs A, Hyrc K, Ma X, Asnani A, Shewale SV, Scherrer-Crosbie M, Cowart LA, Parks JS, Zhao L, Gordon D, Ramirez-Valle F, Margulies KB, Cappola TP, Desai AA, Pedersen LN, Bergom C, Stitziel NO, Rettig MP, DiPersio JF, Hajny S, Christoffersen C, Diwan A, Javaheri A. JACC Basic Transl Sci. 2023 Mar; 8(3):340-355.
Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSMRO. Ji Z, Moore J, Devarie-Baez NO, Lewis J, Wu H, Shukla K, Lopez EIS, Vitvitsky V, Key CC, Porosnicu M, Kemp ML, Banerjee R, Parks JS, Tsang AW, Zhou X, Furdui CM. Front Oncol. 2022; 12:946320.
Early time-restricted feeding improves high-density lipoprotein amount and function in nonhuman primates, without effects on body composition. Kavanagh K, Bashore AC, Davis MA, Jorgensen MJ, McClouth CJ, Beavers DA, Parks JS. Obesity (Silver Spring). 2023 Feb; 31 Suppl 1(Suppl 1):75-84.

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Technology Transfer and Commercialization

Research Focus Areas

Translation to Care

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