Carl D. Langefeld, PhD

Research Interests

Analysis and Methods Development for Genomics

Multi-Omics and Microbiome in Human Disease

Stroke

Kidney Diseases

Autoimmune Diseases

Obesity

About Me

I am a statistical geneticist researching the mapping of complex genetic traits including such traits as familial, but their inheritance patterns appear to differ from simple Mendelian inheritance due to incomplete penetrance, sporadic cases, genetic heterogeneity, epistasis and gene-environment interactions. Thus, the magnitude of the genetic effect may be modest or masked by the complexity of the etiologic mechanism. My ultimate goal of this research is to assist in the isolation and cloning of disease-predisposing genes for the prevention and treatment of the disease.

Research Laboratory

Langefeld Lab - Focusing on the mapping of complex genetic traits which includes the development of association and linkage methods for the mapping of complex genetic traits.

Educational Program Involvement

Molecular Genetics and Genomics PhD
Program Research Interest: Identification of genetic variants that contribute to complex disease, Gene-environment interactions, Epigenetics, Genetic epidemiology, Bioinformatics

Research

Publications

Rare Missense Functional Variants at COL4A1 and COL4A2 in Sporadic Intracerebral Hemorrhage. Chung J, Hamilton G, Kim M, Marini S, Montgomery B, Henry J, Cho AE, Brown DL, Worrall BB, Meschia JF, Silliman SL, Selim M, Tirschwell DL, Kidwell CS, Kissela B, Greenberg SM, Viswanathan A, Goldstein JN, Langefeld CD, Rannikmae K, Sudlow CL, Samarasekera N, Rodrigues M, Al-Shahi Salman R, Prendergast JGD, Harris SE, Deary I, Woo D, Rosand J, Van Agtmael T, Anderson CD. Neurology. 2021 May;
Genome-wide association study of vitamin D concentrations and bone mineral density in the African American-Diabetes Heart Study. Palmer ND, Lu L, Register TC, Lenchik L, Carr JJ, Hicks PJ, Smith SC, Xu J, Dimitrov L, Keaton J, Guan M, Ng MCY, Chen YI, Hanley AJ, Engelman CD, Norris JM, Langefeld CD, Wagenknecht LE, Bowden DW, Freedman BI, Divers J. PLoS One. 2021; 16(5):e0251423.
Genetic landscape of Gullah African Americans. Zimmerman KD, Schurr TG, Chen WM, Nayak U, Mychaleckyj JC, Queen Quet , Moultrie LH, Divers J, Keene KL, Kamen DL, Gilkeson GS, Hunt KJ, Spruill IJ, Fernandes JK, Aldrich MC, Reich D, Garvey WT, Langefeld CD, Sale MM, Ramos PS. Am J Phys Anthropol. 2021 May;
Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage. Acosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Crit Care Med. 2021 May; 49(5):828-837.
Hierarchicell: an R-package for estimating power for tests of differential expression with single-cell data. Zimmerman KD, Langefeld CD. BMC Genomics. 2021 May; 22(1):319.

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Research Interests

Analysis and Methods Development for Genomics
Autoimmune Diseases
Diabetes
Glucose Homeostasis
Kidney Diseases
Multi-Omics and Microbiome in Human Disease
Obesity
Stroke

Technology Transfer and Commercialization

Research Focus Areas

Translation to Care

More Resources

Carl D. Langefeld, PhD

Research Interests

About Me

Research Laboratory

Educational Program Involvement