I am an associate professor at the Wake Forest School of Medicine in the Department of Biostatistics and Data Science as of July 2017, and I am the lead biostatistician with the WF NCI Community Oncology Research Program (NCORP) Research Base. I am also a faculty member in the Biostatistics Shared Resource at the Comprehensive Cancer Center. Previously, I was an associate professor in the Department of Biostatistics and a faculty member of the Biostatistics and Bioinformatics Shared Resource Facility of the Markey Cancer Center at the University of Kentucky. I earned my PhD in the Division of Biostatistics at the Medical University of South Carolina, and while there, participated in biomedical projects in the areas of cancer, neuroscience, and nutrition; during this time, I gained considerable experience working with biologists and clinical investigators.
My primary research interest is in clinical trials. I have expertise in the design of Phase I trials using model-based, adaptive designs such as the continual reassessment method and have developed methods that are variants of this design to incorporate ordinal toxicity grading and mixed toxicity/efficacy outcomes. I additionally have methods work on adaptive interim strategies for single-arm phase II trials with continuous outcomes. I have been involved in the development of over 20 single and multi-center clinical trials where I was the lead statistician in the implementation, management, interim monitoring, and analyses. I am an active member of the Society for Clinical Trials, as I currently serve of the Board of Directors and am former education committee chair. Additionally, I am an active member of AACR, ASCO, and ASA and have participated in NCI and AACR/ASCO-sponsored training workshops on methods in clinical cancer (2012), methods in cancer biostatistics for clinical trials designs with targeted agents (2015), and am a faculty member for the Methods in Clinical Cancer Research Workshop (5-year term).