I am an experienced Principal Investigator with 24 years of continuous NIH funding, and a board-certified veterinary pathologist specializing in the discovery and development of animal models of cancer. My PhD work focused on the effect of tumor hypoxia on radiation therapy in canine patients, and for many years I have studied cancer risk, progression and treatment in nonhuman primates (NHP). I serve as Director of a unique NIH/NIAID Primate Radiation Survivor Core, and as PI of a DOD/CDMRP Focused Program designed to assess cardiac, metabolic, immune, and genomic injury in irradiated nonhuman primates; these two program-level grants focus on normal tissue injury by ionizing radiation. I direct an NIH T32 training program, and have a long successful track record of mentorship. More recently, my lab has developed the Primate Cancer Initiative, which conducts outreach to primate research facilities nationally, to find primates with naturally-occurring cancers and treat them, using novel immunotherapy approaches. This work has high translational value, and helps to support cancer therapy for NHP cancer patients who might not otherwise be treated
J Mark Cline Lab - Focusing on evaluation of radiation effects and cancer risk and progression through the assessment of normal tissues and cancers using a variety of experimental models.
Educational Program Involvement
Molecular Medicine and Translational Science PhD
Program Research Interest: Analytical approaches to molecular and cellular synthesis, structure and function, Genetics and gene regulation, Cell communications, Organ systems, Pathophysiology
Integrative Physiology and Pharmacology PhD
Program Research Interest: Drug and Alcohol Abuse, Cardiovascular Physiology and Hypertension, Regenerative Medicine, Neuro- and Behavioral Pharmacology, Cancer Therapeutics Endocrinology, Diabetes, and Metabolism Lifespan Physiology.