I have a broad background in neurogastroenterology and motility, with more than 35 years’ experience in NIH-funded research in the field. My lab has unique expertise in studying the functional physiological parameters necessary for a functional motility testing of different gut segments and is the first to have developed the technology to co-culture smooth muscle cells with enteric progenitor neural cells. We have also developed the technology to bioengineer internal anal sphincter (IAS) constructs from isolated IAS smooth muscle cells from the rabbit, mouse, pig and human, and we are the first to successfully implant a bioengineered intrinsically innervated human IAS, without rejection. My lab has also developed regenerative medicine approaches to treat diabetic gastroparesis.
Education Program Involvement
Biomedical Engineering PhD
Program Research Interest: Biomaterials, Biomechanics, Biomedical Imaging, Cardiovascular Engineering, Nanomedicine and Nanobioengineering, Neuroengineering, Tissue Engineering, Translational Cancer Research
Integrative Physiology and Pharmacology PhD
Program Research Interest: Drug and Alcohol Abuse, Cardiovascular Physiology and Hypertension, Regenerative Medicine, Neuro- and Behavioral Pharmacology, Cancer Therapeutics Endocrinology, Diabetes, and Metabolism Lifespan Physiology.
Molecular Medicine and Translational Science PhD
Program Research Interest: Analytical approaches to molecular and cellular synthesis, structure and function, Genetics and gene regulation, Cell communications, Organ systems, Pathophysiology