Our laboratory has a sustained basic science translational science program promoting the concept that distorted redox metabolism and disrupted mitochondrial bioenergetics direct the often lethal course of sepsis. The therapeutic concept targets the mitochondrial pyruvate dehydrogenase complex by deactivating pyruvate dehydrogenase kinases with dichloroacetate, which drives TCA cycle fueling, electron transport chain ATP synthesis, and systemic redox balance.
