Hannah Christine Ainsworth, PhD

Assistant Professor, Biostatistics and Data Science, Public Health Sciences (Winston-Salem)

Research Interests

Machine Learning
Complex Diseases
Epigenetics
Bioinformatics
Gene-Environment Interactions
High Performance Computing

Research

Publications

A highly prevalent lupus risk haplotype increases IRF7-dependent induction of IFN-a, enhancing antiviral defense and exacerbating autoimmunity. Virolainen SJ, Creighton K, Dashtiahangar M, Krishnamurthy D, Parks L, Forney C, Ampadu B, Rudrapatna AN, Dunn KA, Parameswaran S, Hesse HK, Chen X, VonHandorf A, Edsall LE, Yin C, Lynch A, Gittens O, Diouf AA, Jones SH, Hass M, Javier E, Donmez O, Keddari Y, Danzinger O, Seelamneni H, Namjou-Khales B, Ainsworth HC, Comeau ME, Marion MC, Glenn SB, Nath SK, Freedman BI, Tsao BP, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, James JA, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Bae SC, Graham DC, Vyse TJ, Guthridge JM, Gaffney PM, Langefeld CD, Kelly JA, Kaufman KM, Sivils KL, Harley JB, Shen N, Lawson LP, Baglaenko Y, Miraldi ER, Rosenberg BR, Siggers T, Waggoner SN, Weirauch MT, Kottyan LC. Am J Hum Genet. 2026 Sep;
Adaptive reorganization of local sleep and prelimbic cortical circuits predict behavioral resilience to social defeat stress. Sebastian EJ, Qiao Z, Arocho A, Bush BJ, Fawole A, Johnson H, Saafir T, Ainsworth HC, Benveniste M, Ehlen JC. J Neurosci. 2026 Sep;
Healthcare experiences and the cycle of genomic healthcare disparities: A cross-sectional study utilizing the 'All of Us' research program. Johnson MD, Hite A, Richmond J, Lisi EC, Ainsworth HC. J Community Genet. 2026 Jul; 17(4)
Unacylated Ghrelin Counteracts Mitochondrial Dysfunction and Neuromuscular Junction Disruption in Cancer Cachexia. Ahn B, Wanagat J, Cleary C, Ainsworth HC, Kim H. Am J Physiol Cell Physiol. 2026 Apr;
A Human Airway-on-a-Chip Microphysiological System for Modeling Chlorine Gas Toxicity. Murphy SV, Rajan SAP, Lindert K, Young T, Jiao Y, Zhou Y, Khoury O, McSwain M, Sittadjody S, Hamid Z, Clapp PW, Leach TS, Orr TC, Shankle D, Whitaker E, Sutton K, Albertson SE, Stumpf K, Mutkus L, Simon T, Kulkarni G, Chan J, Lee J, Cox LA, Li G, Campbell C, Olivier M, Puppala S, Reeves TE, Langefeld CD, Ainsworth HC, Ziegler J, Zinnia A, Khan MS, Marini FC, Walker SJ, Shupe TD, Jacobson A, Furdui CM, Bishop AC, Hall AR, Seeds MC, Reeves KD, Atala A. Toxicol Sci. 2025 Dec;

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Research Interests

Bioinformatics
Complex Diseases
Epigenetics
Gene-Environment Interactions
High Performance Computing
Integrative Omics
Machine Learning
Non-Coding Regulatory Elements
Statistical Genetics
Statistical Methods Development

Technology Transfer and Commercialization

Research Focus Areas

Translation to Care

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Hannah Christine Ainsworth, PhD

Research Interests