About Me

Research Laboratory

Perrino Lab - Studying the biochemistry of DNA and RNA in human disease.

Education Program Involvement

Biochemistry and Molecular Biology PhD
Program Research Interest: Signal transduction in cancer and inflammation
Nucleic acid metabolism in cancer and inflammation, Redox biology, Metabolic diseases such as diabetes and atherosclerosis

Molecular Genetics and Genomics PhD
Program Research Interest: Identification of genetic variants that contribute to complex disease, Gene-environment interactions, Epigenetics, Genetic epidemiology, Bioinformatics

Research

Publications

Identification of Inhibitors of the dNTP Triphosphohydrolase SAMHD1 Using a Novel and Direct High-Throughput Assay. Mauney CH, Perrino FW, Hollis T. Biochemistry. 2018 Nov; 57(47):6624-6636.
TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis. Rego SL, Harvey S, Simpson SR, Hemphill WO, McIver ZA, Grayson JM, Perrino FW. Autoimmunity. 2018 Nov; :1-12.
Solid-State Nanopore Analysis of Diverse DNA Base Modifications Using a Modular Enzymatic Labeling Process. Wang F, Zahid OK, Swain BE, Parsonage D, Hollis T, Harvey S, Perrino FW, Kohli RM, Taylor EW, Hall AR. Nano Lett. 2017 11; 17(11):7110-7116.
The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch. Mauney CH, Rogers LC, Harris RS, Daniel LW, Devarie-Baez NO, Wu H, Furdui CM, Poole LB, Perrino FW, Hollis T. Antioxid. Redox Signal. 2017 Dec; 27(16):1317-1331.
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC. J. Autoimmun. 2017 Jul; 81:13-23.

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Fred W. Perrino, PhD

Fred W. Perrino, PhD

About Me

Research Laboratory

Education Program Involvement