My research combines chemical and systems biology approaches to investigate redox mechanisms of disease. Redox reactions and associated reactive oxygen, sulfur and other species are widely acknowledged as integral regulatory components in signaling, metabolism and epigenetics. The alteration of redox state through acute or chronic accumulation of reactive oxidants leads to numerous pathologies in humans including inflammation, sepsis and cancer. Individual research projects in my group focus on:
- Development of chemical probes and methods for analysis of protein oxidation;
- Structure-function studies of redox-regulated proteins and their pathophysiological implications;
- Cancer prevention, treatment and quality of life with emphasis on lung and head and neck cancer;
- Mechanisms and new therapies targeting inflammation and sepsis; and,
- Biospecimen preservation to advance analysis of clinical biomarkers and precision medicine.
Administratively, I serve as co-director of the Center for Redox Biology and Medicine and T32 Training Program in Redox Biology and Medicine, and as director of the Proteomics and Metabolomics Shared Resource. I serve on the editorial boards for Journal for Biological Chemistry, Chemical Research in Toxicology, and Antioxidants and I chaired conferences in the field of redox biology (e.g., vice-chair for the 2014 and chair for the 2016 Gordon Research Conference on Thiol-Based Redox Regulation & Signaling).
Furdui Lab - Investigating molecular mechanisms linking redox balance to disease development and treatment.
Education Program Involvement
Biochemistry and Molecular Biology PhD
Program Research Interest: Signal transduction in cancer and inflammation
Nucleic acid metabolism in cancer and inflammation, Redox biology, Metabolic diseases such as diabetes and atherosclerosis
Cancer Biology PhD
Program Research Interest: Cellular defense and metabolism, Aberrant signaling pathways in tumor cells, Cell growth and survival, Molecular cancer epidemiology, Gene-environment interactions, Cancer control
Program Research Interest: Analytical approaches to molecular and cellular synthesis, structure and function, Genetics and gene regulation, Cell communications, Organ systems, Pathophysiology