Furdui Lab - Publications

Holmila R.J., Vance S.A., Chen X., Wu H., Shukla K., Bharadwaj M.S., Mims J., Wary Z., Marrs G., Singh R., Molina A.J., Poole L.B., King S.B., Furdui C.M. (2018) “Mitochondria-targeted Probes for Imaging Protein Sulfenylation.” Sci. Rep. Apr 27;8(1):6635.

Chen X., Wu H., Park C.M., Poole T.H., Keceli G., Devarie-Baez N.O., Tsang A.W., Lowther W.T., Poole L.B., King S.B., Xian M., Furdui C.M. (2017) “Discovery of heteroaromatic sulfones as a new class of biologically compatible thiol-selective reagents.” ACS Chem Biol. Aug 18;12(8):2201-2208.

Devarie-Baez N.O., Silva Lopez E.I., Furdui C.M. (2016) “Biological chemistry and functionality of protein sulfenic acids and related thiol modifications.” Free Radic Res. Feb;50(2):172-94.

Poole T.H., Reisz J.A., Zhao W., Poole L.B., Furdui C.M., King S.B. (2014) “Strained cycloalkynes as new protein sulfenic acid traps” J Am Chem Soc. Apr 30;136(17):6167-70. 

Devarie Baez N.O., Reisz J.A., Furdui C.M. (2014) “Mass spectrometry in studies of protein thiol chemistry and signaling: Opportunities and caveats” Free Radic Biol Med. Sep 28. pii: S0891-5849(14)00435-3. 

Furdui C.M., Poole L.B. (2013) “Chemical approaches to detect and analyze protein sulfenic acids.” Mass Spectrom Rev. Mar-Apr;33(2):126-46. 

Reisz J.A., Bechtold E., King S.B., Poole L.B., and Furdui C.M. (2013) “Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.” FEBS J., Dec; 280(23):6150-61. 

Qian J., Wani R., Klomsiri C., Poole L.B., Tsang A.W., Furdui C.M. (2012) “A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of β-ketoesters as cleavable probes.” Chem. Commun. (Camb). 48(34):4091-3.

Qian J., Klomsiri C., Wright M.W., King S.B., Tsang A.W., Poole L.B., Furdui C.M. (2011) “Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.” Chem. Commun. (Camb), 47(32):9203-5. 

Bechtold E., Reisz J.A., Klomsiri C., Tsang A.W., Wright M.W., Poole L.B., Furdui C.M., King S.B. (2010) “Water-soluble triarylphosphines as biomarkers for protein S-nitrosation” ACS Chem. Biol., 5(4):405-14. 

Poole, L.B., Klomsiri, C., Knaggs, S.A., Furdui, C.M., Nelson, K.J., Thomas, M.J., Fetrow, J.S., Daniel, LW, and King, S.B. (2007) “Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins”, Bioconjug. Chem., 18(6):2004-17.

Chen X., Mims J., Huang X., Singh N., Motea E., Planchon S.M., Beg M., Tsang A.W., Porosnicu M., Kemp M.L., Boothman D.A., Furdui C.M. (2017) “Modulators of redox metabolism in head and neck cancer.” Antioxid Redox Signal. Dec 20. [Epub ahead of print]

Lewis J.E., Costantini F., Mims J., Chen X., Furdui C.M., Boothman D.A., Kemp M.L. (2017) “Genome-scale modeling of NADPH-driven β-lapachone sensitization in head and neck squamous cell carcinoma.” Antioxid Redox Signal. Sep 14. [Epub ahead of print]

Chen X., Liu L., Mims J., Punska E.C., Williams K.E., Zhao W., Arcaro K.F., Tsang A.W., Zhou X., Furdui C.M. (2015) “Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors.” Epigenetics. Jun 3;10(6):545-61. 

Mims J., Bansal N., Bharadwaj M.S., Chen X., Molina A.J., Tsang A.W., Furdui C.M. (2015) “Energy metabolism in a matched model of radiation resistance for head and neck squamous cell cancer.” Radiat Res. Mar;183(3):291-304. 

Reisz J.A., Bansal N., Qian J., Zhao W., Furdui C.M. (2014) “Effects of ionizing radiation on biological molecules: Mechanisms of damage and emerging methods of detection.” Antioxid Redox Signal. Jul 10; 21(2):260-92. 

Furdui C.M., (2014) “Ionizing radiation: Mechanisms and Therapeutics” Antioxid Redox Signal. Jul 10;21(2):218-20. 

Bansal N., Mims J., Kuremsky J.G., Olex A.L., Zhao W., Yin L., Wani R., Qian J., Center B., Marrs G.S., Porosnicu M., Fetrow J.S., Tsang A.W., Furdui C.M. (2014) “Broad phenotypic changes associated with gain of radiation resistance in HNSCC.” Antioxid Redox Signal. Jul 10;21(2):221-36. 

Glazer P.M., Grandis J., Powell S.N., Brown J.M., Helleday T., Bristow R., Powis G., Hill R.P., Le Q.T., Pelroy R., Mohla S., Bernhard E.J., DeGregori J., Ivan M., Vaezi A., Boothman D.A., Hammond E., Larner J., Wheeler D., Koumenis C., Chan D., Chen D., Czerniecki B.J., Dewhirst M., Furdui C.M., Lyden D., McBride W.H., Pajonk F., Powis G., Rich J., Haimovitz-Friedman A. (2011) “Radiation resistance in cancer therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010.” Radiat. Res. 176(3):e0016-21. 

Bolduc J.A., Nelson K.J., Haynes A.C., Lee J., Reisz J.A., Graff A.H., Clodfelter J.E., Parsonage D., Poole L.B., Furdui C.M., Lowther W.T. (2018) “Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.” J. Biol..Chem. Jun 8. [Epub ahead of print]

Collins J.A., Wood S.T., Nelson K.J., Rowe M.A., Carlson C.S., Chubinskaya S., Poole L.B., Furdui C.M., Loeser R.F. (2016) “Oxidative stress promotes peroxiredoxin hyperoxidation and attenuates pro-survival signaling in aging chondrocytes.” J Biol Chem. 2016 Mar 25;291(13):6641-54.

Haynes A.C., Qian J., Reisz J.A., Furdui C.M., Lowther W.T. (2013) “Molecular basis for the resistance of human mitochondrial 2-Cys peroxiredoxin 3 to hyperoxidation.” J Biol Chem. 288(41):29714-23.

Jönsson T.J., Tsang A.W., Lowther W.T., Furdui C.M. (2008) “Identification of intact protein thiosulfinate intermediate in the reduction of cysteine sulfinic acid in peroxiredoxin by human sulfiredoxin.” J. Biol. Chem., 283(34):22890-4. 

Yang M., Wu H., Chu J., Gabriel L.A., Kim Y., Anderson K.S., Furdui C.M., Bierbach U. (2018) “Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.” Chem. Commun. (Camb). Jul 11;54(54):7479-7482.

Long D., Wu H., Tsang A.W., Poole L.B., Yoza B.K., Wang X., Vachharajani V., Furdui C.M., McCall C.E. (2017) “The oxidative state of cysteine thiol 144 regulates the SIRT6 glucose homeostat.” Sci Rep. Sep 8;7(1):11005.

Keyes J.D., Parsonage D., Yammani R.D., Rogers L.C., Kesty C., Furdui C.M., Nelson K.J., Poole L.B. (2017) “Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.” Free Radic Biol Med. Nov;112:534-543.

Dean T.C., Yang M., Liu M., Grayson J.M., DeMartino A.W., Day C.S., Lee J., Furdui C.M., Bierbach U. (2017) “Human serum albumin-delivered [Au(PEt3)]+ is a potent inhibitor of T cell proliferation.” ACS Med Chem Lett. Apr 25;8(5):572-576. 

Mauney C.H., Rogers L.C., Harris R.S., Daniel L.W., Devarie-Baez N.O., Wu H., Furdui C.M., Poole L.B., Perrino F.W., Hollis T. (2017) “The SAMHD1 dNTP triphosphohydrolase is controlled by a redox switch.” Antioxid Redox Signal. Dec 1;27(16):1317-1331.

Wajih N., Liu X., Shetty P., Basu S., Wu H., Hogg N., Patel R.P., Furdui C.M., Kim-Shapiro D.B. (2016) “The role of red blood cell S-nitrosation in nitrite bioactivation and its modulation by leucine an glucose.” Redox Biol. Apr 30;8:415-421.

Wood S.T., Long D.L., Reisz J.A., Yammani R.R., Burke E.A., Klomsiri C., Poole L.B., Furdui C.M., Loeser R.F. (2016) “Cysteine-mediated redox regulation of cell signaling in chondrocytes stimulated with fibronectin fragments.” Arthritis Rheumatol. Jan;68(1):117-26.

Swanner J., Mims J., Carroll D.L., Akman S.A., Furdui C.M., Torti S.V., Singh R.N. (2015) “Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.” Int J Nanomedicine. Jun 11;10:3937-53.

Wani R., Tsang A.W., Furdui C.M. (2011) “Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle.” Cell Cycle. Oct 1;10(19). 

Wani R., Qian J., Yin L., Bechtold E., King S.B., Poole L.B., Paek E., Tsang A.W. and Furdui C.M. (2011) “Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species” Proc. Natl. Acad. Sci. U.S.A., 108(26):10550-5.

Lew E.D., Furdui C.M., Anderson K.S. and Schlessinger J. (2009) “The precise sequence of FGF-receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations” Science Signaling, 2 (58), ra6.

Furdui, C.M., Lew, E. D., Schlessinger, J. and Anderson, K.S. (2006) “Temporal resolution of fibroblast growth factor receptor kinase autophosphorylation”, Mol. Cell, 21(5):711-7.