Jin G., Lee S.W., Zhang X., Cai Z., Gao Y., Chou P.H., Rezaeian A.H., Han F., Wang C.Y., Yao J.C., Gong Z., Chan C.H., Huang C.Y., Tsai F.J., Tsai C.H., Tu S.H., Wu C.H., Sarbassov D., Ho Y.S., Lin H.K. Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-depedent mTORC1 hyperactivation by recruiting GATOR1. Mol. Cell. 2015 Jun 18;58(6):989-1000. doi: 10.1016/j.molcel.2015.05.010. Epub 2015 Jun 4.
Xu D, Li CF, Zhang X, Gong Z, Jin G, Lee SW, Jin G, Rezaeian AH, Chan CH, Han F, Wang J, Yang WL, Feng ZZ, Chen W, Wu CY, Wang YJ, Chow LP, Zhu XF, Zeng YX, Lin HK. Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition, polyploidy and tumourigenesis. Nat. Commun. 2015 Mar 30;6:6641. doi: 10.1038/ncomms7641.
Lee SW, Li CF, Jin G, Chan CH, Yang WL, Li BK, Cai Z, Han F, Rezaeian AH, Li HY, Huang HY, Lin HK. Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress. Mol. Cell. 2015 Mar 19;57(6):1022-33. doi: 10.1016/j.molcel.2015.01.015. Epub 2015 Feb 26.
Feng H, Lopez GY, Kim CK, Alvarez A, Duncan CG, Nishikawa R, Nagane M, Su AJ, Auron PE, Hedberg ML, Wang L, Raizer JJ, Kessler JA, Parsa AT, Gao WQ, Kim SH, Minata M, Nakano I, Grandis JR, McLendon RE, Bigner DD, Lin HK, Furnari FB, Cavenee WK, Hu B, Yan H, Cheng SY. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. J. Clin. Invest. 2014 Jul 25. pii: 73093. doi: 10.1172/JCI73093. [Epub ahead of print]
Wang J, Han F, Lee SW, Wu J, Chan CH, Zhang X, Gao Y, Su HK, Feng ZZ, Xu DZ, Lin HK. E3-ligase Skp2 regulates β-catenin expression and maintains hematopoietic stem cell homing. Biochem Biophys Res Commun. 2014 Feb 18. pii: S0006-291X(14)00294-0. doi: 10.1016/j.bbrc.2014.02.042. [Epub ahead of print].
Wagner, K., Alam, H., Dhar, S., Giri, U., Li, N., Wei, Y., Giri, D., Cascone, T., Kim., J.-H., Ye, Y., Multani, A., Chan, C.-H., Erez, B., Saigal, B., Chung, J., Lin, HK., Wu, X., Hung, MC, Heymach, J., Lee, M. G. (2013) KDM2A Activates ERK1/2 via DUSP3’s Epigenetic Repression and Promotes NSCLC, J. Clin. Invest. 123(12):5231-46.
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg, LJ, Ladbury, J, Cai Z, Xu, D, Logothetis, CJ, Hung, MC, Zhang S*, Lin HK*. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression (2013). Cell. 154, 556-68. PMID: 23911321.
Yang WL, Jin G, Li CF, Jeong YS, Moten A, Xu D, Feng Z, Chen W, Cai Z, Darnay B, Gu W, Lin HK. Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling (2013). Science Signaling. 2013 Jan 8;6(257):ra3. doi: 10.1126/scisignal.2003197.
Chen D, Sun Y, Wei Y, Zhang P, Rezaeian A.H, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L (2012). LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat. Med. 2012 Oct;18(10):1511-7. doi: 10.1038/nm.2940. Epub 2012 Sep 23.
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KC, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama K, Lin HK (2012). The Skp2-SCF ubiquitin ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis. Cell. 149:1098-111. PMID: 22632973.
Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, Chan CH, Li JM, Wang J, Gao Y, Han F, Jeong YS, Yuan Z, Khanna KK, Jin J, Zeng YX, Lin HK (2012). Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol. Cell.11;46(3):351-61. Epub 2012 Mar 29. PMID: 22464731.
Wu J, Lee SW, Zhang X, Han F, Kwan SY, Yuan X, Yang WL, Jeong YS, Rezaeian AH, Gao Y, Zeng YX, Lin HK. Foxo3a transcription factor is a negative regulator of Skp2 and Skp2 SCF complex (2012). Oncogene 2012 Feb 6. doi: 10.1038/onc.2012.26. [Epub ahead of print].
Wang J, Han F, Wu J, Lee SW, Chan CH, Wu CY, Yang WL, Gao Y, Zhang X, Jeong YS, Moten A, Samaniego F, Huang P, Liu Q, Zeng YX, Lin HK (2011). The role of Skp2 in the maintenance of quiescence and self-renewal of hematopoietic stem cells. Blood, 118, 5429-38.
Wu CH, Kang HY, Yang WL, Wu J, Jeong YS, Wang J, Chan CH, Lee SW, Zhang X, Lamothe B, Aejandro D. Campos, Darnay B, Lin HK (2011). The critical role of monoubiquitination of H2AX in H2AX phosphorylation and DNA damage. J. Biol.Chem. 286, 30806-15.
Giorgi C, Ito K, Lin HK, Santangelo C, Bersadi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP (2010) Essential role of PML in the regulation of Ca2+-depedent apoptosis at endoplasmic reticulum-mitochondria contact sites. Science, 330, 1247-1251.
Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK (2010). Deciphering the transcription complex critical for RhoA gene expression and cancer metastasis. Nat. Cell Biol. 12, 457-467.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner B, Lin X, Darnay B, Lin HK (2009). The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 325, 1134-1138.
Lin HK, Chen Z, Wang G, Lee SW, Wang J, Chan CH, Yang WL, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP (2010) Skp2 targeting suppresses tumorigenesis by Arf-p53-indepedent cellular senescence. Nature (Article), 464, 374-379.
Lin HK*, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nimer S, Tempst P, Pandolfi PP* (2009) Phosphorylation-dependent regulation of the SCF complex formation and Skp2 oncogenic function by Akt/PKB. Nat. Cell Biol.11, 420-432. *Co-Corresponding author.
Chen Z, Trotman LC, Dotan ZA, Lin HK, Niki M, Koutcher JA, Ludwig T, Cordon-Cardo, C, Pandolfi PP (2005) Critical role of p53 dependent cellular senescence in suppression of Pten deficient tumourigenesis. Nature. 436, 725-730.
Lin HK, Bergmann S, Pandolfi PP (2004) Cytoplasmic PML function in TGF-β signaling. Nature. 431, 205- 211.
Full publications can be seen from PubMed