The Bioinformatics Shared Resource (BISR) collaborates with clinical, cancer control, and basic science investigators to use genomics and informatics approaches in cancer research.

We help researchers:

  • Better understand the complex processes involved in the development and progression of various types of cancer, especially tobacco-related cancers
  • Use this knowledge to predict cancer recurrence, metastasis and response to therapies
  • Assign patients to specific targeted therapies, such as immunotherapies, to improve survival and quality-of-life

Our objectives for improving patient outcomes include:

  • Identifying germline and somatic genetic and epigenetic alterations that are associated with the development and progression of cancer
  • Identifying genetic and epigenetic events and mutation signatures in cancers caused by environmental factors, such as tobacco
  • Identifying ethnicity-related genetic and epigenetic alterations that may be underlying factors in health disparities
  • Utilizing genetic and epigenetic information for early detection of cancer (personalized risk prediction) and prediction of cancer recurrence and progression (personalized monitoring)
  • Promoting precision medicine (personalized intervention)
  • Understanding the functional mechanisms by which genetic and epigenetic findings have a direct effect on cancer

Focus Areas and Goals

The primary goal of the BISR is to facilitate the peer-reviewed research and extramural grant application of Wake Forest Baptist Comprehensive Cancer Center members. We collaborate with members from all scientific programs throughout all phases of cancer-related research projects.

Major responsibilities are assumed for methodological-, computational-, and bioinformatics-related issues, including study design (including sample size, platform and sequencing depth), sampling, interim reviews, and final analysis and result delivery.

We focus on:

  • Bioinformatics-based design and data analysis in support of grant development and publications
  • Informatics services to Comprehensive Cancer Center investigators from all programs, including genomics data processing, bioinformatics analyses, data annotation and visualization/sharing to support basic, translational and clinical cancer research by leveraging the institutionally maintained Translational Data Warehouse
  • Leadership, education, and training, including participating in graduate-level courses and T32 training grants
  • Mentoring teams for K awardees and other young investigators
  • Facilitating membership and leadership on committees responsible for scientific and administrative decisions for the Comprehensive Cancer Center
  • Providing short courses on statistical or bioinformatics methods for Comprehensive Cancer Center members

Services Provided

The BISR provides sophisticated informatics analyses of data obtained from genomics projects, including the following:

Additional analyses can be provided, such as:
  • Development, monitoring and analyzing clinical protocol
  • Designing bioinformatics approaches and analyzing genomic data in support of grant development and publications
  • Data analysis services for other platforms; e.g., CLIP-seq, DNA methylation sequencing, CRISPR/targeted sequencing and single-cell sequencing
  • Proteomics (interactome, expression and PTM) and metabolomics (MSEA, biomarker and pathway)
  • Array-based analyses (gene expression, SNP, and copy number and DNA methylation)
  • Participating in Comprehensive Cancer Center committees responsible for the scientific and administrative direction of the Comprehensive Cancer Center
  • Collaborating with investigators when interpreting results, final project report with analysis methods and providing publication-ready graphics and references
  • Collaborating with Comprehensive Cancer Center members in the development and submission of externally funded grants